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Preparation method of nanometer mesoporous silica styptic powder with antibacterial and hemostatic functions

A mesoporous silica and nano-mesoporous technology, applied in biochemical equipment and methods, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve difficult problems, lack of biological activity, etc. problems, to achieve the effect of improved performance, good hemostatic performance, and mild reaction conditions

Pending Publication Date: 2020-04-10
SHANGHAI CHANGHAI HOSPITAL
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of hemostatic material is a single hemostatic material and does not have other biological activities
An ideal hemostatic powder should have the following two biological activities at the same time: hemostasis and antibacterial, but the current hemostatic materials are difficult to take into account these two biological functions

Method used

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  • Preparation method of nanometer mesoporous silica styptic powder with antibacterial and hemostatic functions
  • Preparation method of nanometer mesoporous silica styptic powder with antibacterial and hemostatic functions
  • Preparation method of nanometer mesoporous silica styptic powder with antibacterial and hemostatic functions

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Embodiment １

[0031] The present invention synthesizes mesoporous silicon dioxide nanoparticles through a two-phase method, carries out antibacterial drug loading through the huge specific surface area of ​​the mesoporous silicon dioxide, encapsulates them with dopamine, and uses dopamine as a drug carrier to load thrombin. The local release of dopamine and thrombin can respectively constrict blood vessels and release coagulation substances, which can achieve synergistic hemostasis. At the same time, the antibiotics released can resist infection, achieve hemostasis and antibacterial. The specific process is as follows:

[0032] (1): Mesoporous silica loaded vancomycin:

[0033] (1.1): Synthesis of mesoporous silica nanoparticles: Dissolve 6.0 g CTAC in 60 mL deionized water, heat to 60 °C, and stir to dissolve. Then 100 μL TEA was added and stirring was continued for 1 hour. Then, 20% volume of TEOS cyclohexane solution was added dropwise, and the reaction was continued for 8 hours until a...

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Abstract

The invention relates to a preparation method of nanometer mesoporous silica styptic powder with antibacterial and hemostatic functions. According to the invention, mesoporous silica is synthesized, and antibacterial drug loading is carried out through the huge specific surface area of the mesoporous silica; and dopamine is used for packaging, and is used as a drug carrier for thrombin loading. Compared with traditional styptic powder, the styptic powder prepared in the invention can locally release dopamine and thrombin to realize blood vessel contraction and blood coagulation substance release respectively, and synergistic hemostasis can be achieved. An antibacterial agent released by the mesoporous silica has an antibacterial property. Therefore, the nanometer mesoporous silica stypticpowder can be applied to dressings used for resisting bacteria and stopping bleeding. The method is simple in process and low in production cost; and the styptic powder solves the problems of continuous wound bleeding and possible infection, can promote healing of infected bleeding wounds, and has very important significance.

Description

technical field [0001] The invention relates to a preparation method of nano mesoporous silicon dioxide hemostatic powder with antibacterial and hemostatic functions. The invention firstly synthesizes mesoporous silica, loads antibacterial drugs through the huge specific surface area of ​​mesoporous silica, encapsulates with dopamine, and uses dopamine as a drug carrier to load thrombin to obtain the required hemostatic powder. Compared with the traditional hemostatic powder, the hemostatic powder prepared by the present invention uses mesoporous silicon dioxide as a hemostatic material carrier, which can locally release dopamine and thrombin to constrict blood vessels and release coagulation substances to achieve the purpose of hemostasis. Background technique [0002] Wound bleeding, oozing and infection are currently the problems that need to be solved in surgery. Most of the hemostatic powders used in clinical practice are biocompatible and absorbable biomaterials, which...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K9/14A61K47/04A61K47/18A61P7/04A61P31/04A61K38/14
CPCA61K38/4833C12Y304/21005A61K38/14A61K9/143A61K9/145A61P7/04A61P31/04A61K2300/00
Inventor 章浩纪方徐凯航王光超唐昊魏强郝荣智丁文彬佟大可丁晨
Owner SHANGHAI CHANGHAI HOSPITAL
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