Preparation method of nanometer mesoporous silica styptic powder with antibacterial and hemostatic functions
A mesoporous silica and nano-mesoporous technology, applied in biochemical equipment and methods, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve difficult problems, lack of biological activity, etc. problems, to achieve the effect of improved performance, good hemostatic performance, and mild reaction conditions
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[0031] The present invention synthesizes mesoporous silicon dioxide nanoparticles through a two-phase method, carries out antibacterial drug loading through the huge specific surface area of the mesoporous silicon dioxide, encapsulates them with dopamine, and uses dopamine as a drug carrier to load thrombin. The local release of dopamine and thrombin can respectively constrict blood vessels and release coagulation substances, which can achieve synergistic hemostasis. At the same time, the antibiotics released can resist infection, achieve hemostasis and antibacterial. The specific process is as follows:
[0032] (1): Mesoporous silica loaded vancomycin:
[0033] (1.1): Synthesis of mesoporous silica nanoparticles: Dissolve 6.0 g CTAC in 60 mL deionized water, heat to 60 °C, and stir to dissolve. Then 100 μL TEA was added and stirring was continued for 1 hour. Then, 20% volume of TEOS cyclohexane solution was added dropwise, and the reaction was continued for 8 hours until a...
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