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A kind of hemostatic sponge and preparation method thereof

A technology of hemostatic sponge and sponge, which is applied in the field of medical devices, can solve the problems of no degradation, low compressive support strength, etc., and achieve obvious effects and convenient use

Active Publication Date: 2021-04-27
PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hemostatic material prepared by this method does not have the advantage of degradation, and the compressive support strength is low

Method used

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  • A kind of hemostatic sponge and preparation method thereof
  • A kind of hemostatic sponge and preparation method thereof
  • A kind of hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Accurately weigh 2 g of SA, place it in 100 mL of distilled water, and stir until completely dissolved. Add 1g CS to the above SA solution, so that the concentration of CS is 1% (mass percentage), and continue to stir for 2h until the CS particles are uniformly mixed in the SA solution, and add 2mL of 10% acetic acid to the mixed solution (so that the final volume concentration of acetic acid is 0.5 %), stir evenly, inject the mixed solution into the mold, pre-freeze at -20°C for 3-4h, and vacuum-dry at 0-10°C for 24h to obtain a freeze-dried sponge. Place it in a coagulation bath and soak for 2 hours to obtain a sodium alginate-chitosan composite sponge, wherein the coagulation bath contains calcium chloride with a mass concentration of 1%, and a glycerol content of 2%. The sponge is dried in an oven to remove ethanol in the sponge to obtain a hemostatic sponge.

Embodiment 2

[0057] Accurately weigh 4 g of SA, place it in 100 mL of distilled water, and stir until completely dissolved. Add 1g CS to the above SA solution, so that the concentration of CS is 1% (mass percentage), and continue to stir for 2h until the CS particles are uniformly mixed in the SA solution, and add 2mL of 10% acetic acid to the mixed solution (so that the final volume concentration of acetic acid is 0.5 %), stir evenly, inject the mixed solution into the mold, pre-freeze at -20°C for 3-4h, and vacuum-dry at 0-10°C for 24h to obtain a freeze-dried sponge. Place it in a coagulation bath and soak for 2 hours to obtain a sodium alginate-chitosan composite sponge, wherein the coagulation bath contains calcium chloride with a mass concentration of 1%, and a glycerol content of 2%. The sponge is dried in an oven to remove ethanol in the sponge to obtain a hemostatic sponge.

Embodiment 3

[0059] Accurately weigh 2 g of SA, place it in 100 mL of distilled water, and stir until completely dissolved. Add 1g CS to the above SA solution, so that the concentration of CS is 1% (mass percentage), and continue to stir for 2h until the CS particles are uniformly mixed in the SA solution, and add 2mL of 10% acetic acid to the mixed solution (so that the final volume concentration of acetic acid is 0.5 %), stir evenly, inject the mixed solution into the mold, pre-freeze at -20°C for 3-4h, and vacuum-dry at 0-10°C for 24h to obtain a freeze-dried sponge. Place it in a coagulation bath and soak for 2 hours to obtain a sodium alginate-chitosan composite sponge, wherein the coagulation bath contains a calcium chloride mass concentration of 0.1%, a glycerol content of 2%, and a large amount of absolute ethanol after washing and crosslinking The sponge is dried in an oven to remove ethanol in the sponge to obtain a hemostatic sponge.

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Abstract

The present invention provides a kind of hemostatic sponge, and described hemostatic sponge comprises chitosan, sodium alginate, acetic acid, cross-linking agent and water; The present invention also provides a kind of preparation method of hemostatic sponge; The hemostatic sponge provided by the present invention , using sodium alginate and chitosan as the main raw materials to prepare a sodium alginate-chitosan composite sponge with good hemostatic properties, which still has high strength after absorbing a large amount of blood, and the compressive load per square centimeter can reach 0.2N Left and right, the blood vessels on the surface of the cavity are compressed to stop bleeding, and the sponge that absorbs blood or seepage fluid can also be degraded quickly, and can be degraded within 1 day at the fastest, and the degradation products automatically flow out of the cavity, which cleverly combines the performance of compression strength and rapid degradation , The product is easy to use and the effect is obvious.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to a hemostatic sponge and a preparation method thereof. Background technique [0002] For the treatment of hemorrhage in cavities rich in blood vessels such as ears and nose, suturing and hemostasis cannot be performed due to the special location and the limitation of the scope of operation. Local packing and compression to stop bleeding has become the most effective and common method. The purpose of packing is not only to stop bleeding and prevent adhesion, but also to give patients a more comfortable treatment experience. [0003] After functional ear and nasal endoscopic surgery, Vaseline gauze, absorbent cotton, expansion sponge and other non-degradable materials are often used to fill the operation cavity to achieve the effect of compression and hemostasis. Although the hemostatic effect is good, such materials have disadvantages such as long filling time, poor biocompatibility, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/0036A61L24/0042A61L24/08A61L2400/04C08L5/08C08L5/04
Inventor 杨瑞魏征谢建
Owner PUYI (SHANGHAI) BIOTECHNOLOGY CO LTD
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