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Water-soluble hemostatic material and preparation method thereof

A hemostatic material, water-soluble technology, applied in medical science, bandages, absorbent pads, etc., can solve problems such as inability to degrade and absorb in vivo, poor hemostatic effect of chitosan, and inability to use small molecular weight chitosan as a hemostatic material, etc., to achieve Good hemostatic performance, strong hemostatic effect, increasing platelet adhesion and thrombus formation

Inactive Publication Date: 2011-09-28
WEIGAO HLDG +1
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides a water-soluble hemostatic material and its preparation in order to solve the defects that chitosan with small molecular weight cannot be used as a hemostatic material, while chitosan with large molecular weight cannot be degraded and absorbed in the body, and chitosan has poor hemostatic effect. method

Method used

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  • Water-soluble hemostatic material and preparation method thereof
  • Water-soluble hemostatic material and preparation method thereof
  • Water-soluble hemostatic material and preparation method thereof

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specific Embodiment approach 1

[0019] Specific embodiment 1: The water-soluble hemostatic material of this embodiment is made of oxidized regenerated cellulose, a chitosan solution, and a strong alkali alcohol solution; wherein the carboxyl content of the oxidized regenerated cellulose is 16%-24% (mass), The degree of polymerization is 100.00-40.00; the degree of deacetylation of chitosan is 80%-95%; the degree of neutralization of carboxyl groups in the oxidized regenerated cellulose is 1%-98%.

[0020] Because the water-soluble hemostatic material of this embodiment can quickly form a very viscous gel when it encounters water or sodium chloride solution, it can fill the wound space, compress and block the blood vessel wound, and is accompanied by obvious membrane formation, so chitosan can It is sent into the depth of the wound, and it is ensured that the chitosan will not be lost due to heavy bleeding, so that the coagulation effect of chitosan can be exerted and effective. Therefore, the water-soluble hemos...

specific Embodiment approach 2

[0022] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the chitosan solution is an aqueous solution of chitosan with a mass fraction of 1% to 20%, and the molecular weight of the chitosan is 500 to 5000; or The glycan solution is a dilute acid solution of chitosan with a mass fraction of 0.5% to 10%. The molecular weight of chitosan is 10,000 to 1,000,000. The volume fraction of the dilute acid solvent used in the dilute acid solution of chitosan is 1% to 5%. The solvent is acetic acid, citric acid, salicylic acid, tartaric acid or ascorbic acid. Others are the same as the first embodiment.

specific Embodiment approach 3

[0023] Specific embodiment three: This embodiment is different from specific embodiment one or two in that the strong base in the strong base alcohol solution is sodium hydroxide and / or potassium hydroxide, and the alcohol solvent is methanol, ethanol or propanol; The concentration of the strong base in the alkali alcohol solution is 0.005 to 3.00 mol / L. Others are the same as the first or second embodiment.

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Abstract

The invention provides a water-soluble hemostatic material and a preparation method thereof, relating to a hemostatic material and a preparation method thereof. The invention solves the defects that the existing chitosan hemostatic material has poor hemostatic performance and can not deal with a larger amount of bleeding. The water-soluble hemostatic material is prepared from oxidized regenerated cellulose, chitosan solution and alkaline alcoholic solution. The preparation method comprises the following steps of: (1) soaking the oxidized regenerated cellulose into the chitosan solution, then carrying out suction filtration for washing with deionized water, and removing the moisture on the surface of the oxidized regenerated fiber loaded with chitosan; (2) putting the oxidized regenerated fiber loaded with chitosan into the alkaline alcoholic solution to be sealed to carry out a neutralization reaction; and (3) flushing with ethanol solution, then flushing with anhydrous ethanol, and drying to obtain the water-soluble hemostatic material. The water-soluble hemostatic material provided by the invention can be used as a hemostatic material.

Description

Technical field [0001] The invention relates to a hemostatic material and a preparation method thereof. Background technique [0002] As a hemostatic material, chitosan has the advantages of promoting blood coagulation, promoting wound healing, absorbing wound exudate, and not easy to synergize. Because the polycation of chitosan is easy to act on the negatively charged groups on the surface of fungal cells, it can change the fluidity and permeability of the cell membrane of pathogenic bacteria, and it can also interfere with DNA replication and transcription, and can block the metabolism of pathogens. Therefore, chitosan has the advantages of inhibiting the growth of bacteria and fungi as a hemostatic material. [0003] Small molecular weight chitosan cannot be used as a hemostatic material because of its water solubility, while large molecular weight chitosan cannot be degraded and absorbed in the body, so it is currently mainly used as a medical hemostatic dressing (such as chi...

Claims

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Application Information

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IPC IPC(8): A61L15/28
Inventor 贺金梅黄玉东王凤文吴亚东张华威汤飞
Owner WEIGAO HLDG
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