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3D printed bionic anti-rejection artificial skin and preparation method thereof

An artificial skin, 3D printing technology, applied in the field of artificial skin, can solve problems such as immune rejection

Active Publication Date: 2020-04-07
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In order to solve the problem of immune rejection in the process of skin substitute transplantation, the present invention proposes a 3D printed bionic anti-rejection artificial skin and its preparation method

Method used

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  • 3D printed bionic anti-rejection artificial skin and preparation method thereof
  • 3D printed bionic anti-rejection artificial skin and preparation method thereof
  • 3D printed bionic anti-rejection artificial skin and preparation method thereof

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Embodiment Construction

[0037] The present invention will be further elaborated below through specific embodiments in conjunction with the accompanying drawings.

[0038] The preparation method of the bionic anti-rejection artificial skin of 3D printing of the present invention, such as Figure 7 shown, including the following steps:

[0039]1) Use Solidworks to build a 3D model of 2mm×2mm×2mm bionic anti-rejection artificial skin, import it into Slic3r for slicing, obtain a 2D model, generate a gcode file, and then import the gcode file into Pronterface software to control 3D printer;

[0040] 2) Prepare the precursor solution:

[0041] a) Dissolve 0.2g of chitosan (CTS) and 1.2g of gelatin (GEL) in 20ml of acetic acid solution with a volume fraction of 0.5%, heat and stir for 6h in a water bath at 60°C at a speed of 900r / min until they are completely dissolved , and then ultrasonically remove the bubbles, and leave it at room temperature for 24h to obtain a precursor solution in which the concen...

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Abstract

The invention discloses a 3D printed bionic anti-rejection artificial skin and a preparation method thereof. The preparation method comprises the following steps: dissolving a polysaccharide substancewith an amino group and protein in an acidic solution to obtain a precursor solution, dissolving spermidine and micromolecular dialdehyde or a high polymer material of which two ends are modified byaldehyde groups into absolute ethyl alcohol to obtain a spermidine cross-linking agent; employing a 3D biological printing method, printing a precursor solution in a culture dish, atomizing the spermidine cross-linking agent, controlling the hardness of each layer by controlling the concentration of the spermidine cross-linking agent of each layer, and finally obtaining the bionic anti-rejection artificial skin with the hardness changing in a gradient mode. According to the invention, the problem of a rejection reaction caused by animal-derived natural polymer artificial skin is solved by utilizing natural anti-rejection biological small molecular spermidine; artificial skin with strength gradient and microstructure is prepared by using a 3D printing method, and the problem that an existing skin substitute is not matched with the biomechanical property of human skin is solved.

Description

technical field [0001] The invention relates to artificial skin technology, in particular to a 3D printed bionic anti-rejection artificial skin and a preparation method thereof. Background technique [0002] The skin is the largest organ in the human body and has important protective and physiological functions. Severe skin defects caused by burns, wounds, and refractory skin ulcers (such as diabetic foot) are major medical and public health problems that countries all over the world are facing today. In clinical practice, it is necessary to transplant natural skin or artificial skin on the surface of difficult-to-heal wounds and large-area wound repair. Although natural skin (including autologous skin, allogeneic skin, and heterogeneous skin) has a structure and function close to that of the recipient skin, there are problems such as insufficient skin source, immune rejection, and virus transmission, so its application in large-area wound repair is limited. The artificial...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/22A61L27/50A61L27/60B33Y50/02B33Y70/10B33Y80/00
CPCA61L27/20A61L27/222A61L27/50A61L27/60B33Y50/02B33Y70/00B33Y80/00C08L5/08
Inventor 刘镇宁吴倩倩仲英惠梁嵩刘庆萍秦政王丽王振国
Owner JILIN UNIV
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