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Rare earth up-conversion-bismuth diagnosis and treatment integrated nano hybrid system, preparation method and application

A rare earth up-conversion, bismuth nanotechnology, applied in preparations for in vivo experiments, pharmaceutical formulations, preparation of X-ray contrast agents, etc. Good compatibility and high sensitivity

Inactive Publication Date: 2020-04-03
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the preparation method provided by this invention has many steps and complicated process, which is not conducive to realizing industrialization; the application of the prepared drug carrier material also has certain limitations.

Method used

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  • Rare earth up-conversion-bismuth diagnosis and treatment integrated nano hybrid system, preparation method and application
  • Rare earth up-conversion-bismuth diagnosis and treatment integrated nano hybrid system, preparation method and application
  • Rare earth up-conversion-bismuth diagnosis and treatment integrated nano hybrid system, preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0040] See Figure 1-5 , a photoresponsive controllable drug release provided in this embodiment is a rare earth upconversion-bismuth integrated nano-hybrid system for diagnosis and treatment. A rare earth upconversion-bismuth nanoparticle nanohybrid system with mesoporous silica coating and core-shell structure formed in the silica shell, and the mesoporous silica channels are loaded with albinohydrochloride Mycin drug, meanwhile, the drug is encapsulated by azobenzene compound.

[0041] A preparation method of the aforementioned rare earth upconversion-bismuth diagnosis and treatment integrated nano-hybrid system with controllable drug release in response to light, specifically comprising the following steps:

[0042] (1) Prepare 10 mg of oil-soluble rare earth thulium-doped up-conversion nano-luminescent particles with a particle size of 25-30 nm, and disperse them in cyclohexane;

[0043] (2) Dissolve 0.1g of bismuth nitrate and 0.25-0.35g of polyvinylpyrrolidone (PVP) i...

Embodiment 2

[0050] See figure 2 The photoresponsive controllable drug release rare earth upconversion-bismuth integrated nano-hybrid system for diagnosis and treatment provided in this embodiment and its preparation method are basically the same as in Example 1, except that it includes the following steps:

[0051] (1) Prepare 10 mg of oil-soluble rare earth thulium-doped up-conversion nano-luminescent particles with a particle size of 25-30 nm, and disperse them in cyclohexane;

[0052] (2) Dissolve 0.1g of bismuth nitrate and 0.25-0.35g of polyvinylpyrrolidone (PVP) in 10mL of glycerin, heat to 60°C and stir for 1 hour, fully stir and dissolve. Then quickly add 0.05g of sodium borohydride, then add 5mL of absolute ethanol, stir for 1min, then centrifuge with water and ethanol at a low temperature of 4°C, and disperse in 10mL of ultrapure water to form the first dispersion;

[0053] (3) Weigh 0.1g of cetyltrimethylammonium bromide (CTAB) as a surfactant, dissolve it in 20mL of water, h...

Embodiment 3

[0059] See image 3 , the photoresponsive controllable drug release rare earth upconversion-bismuth integrated nano-hybrid system for diagnosis and treatment provided in this example and its preparation method are basically the same as those in Example 1-2, except that it includes the following steps :

[0060] (1) Prepare 10 mg of oil-soluble rare earth erbium-doped up-conversion nano-luminescent particles with a particle size of 25-30 nm, and disperse them in cyclohexane;

[0061] (2) Dissolve 0.05g of bismuth nitrate and 0.125-0.175g of polyvinylpyrrolidone (PVP) in 10mL of glycerin and 5mL of ethanol, heat to 60°C and stir for 1 hour, fully stir and dissolve. Then quickly add 0.025g of sodium borohydride, stir for 1min, then centrifuge with water and ethanol at a low temperature of 4°C, and disperse in 5mL of ultrapure water to form the first dispersion;

[0062] (3) Weigh 0.05g of cetyltrimethylammonium bromide (CTAB) as a surfactant, dissolve it in 10mL of water, heat ...

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Abstract

The invention discloses a rare earth up-conversion-bismuth diagnosis and treatment integrated nano hybrid system with photoresponse controllable drug release. Rare earth up-conversion nano light-emitting particles and metal bismuth nano particles are used as inner cores, and the inner cores are simultaneously coated by a silicon dioxide shell layer to form the amino rare earth up-conversion-bismuth nanoparticle nano hybrid system with a mesoporous silicon dioxide coating and a core-shell structure. Besides, a doxorubicin hydrochloride medicine is loaded in a mesoporous silicon dioxide pore channel, and meanwhile, the medicine is encapsulated by an azobenzene compound. The invention also discloses a preparation method of the system. The preparation method comprises the following steps: modifying the periphery of the up-conversion nanoparticles with a surfactant; acquiring ultra-small metal bismuth nanoparticles through an oxidation-reduction method; mixing the bismuth nanoparticles andthe up-conversion nanoparticles, and forming a mesoporous silica layer on the surface of the obtained mixture; loading doxorubicin hydrochloride into the mesoporous channel; and packaging the mesoporous channel by using azobenzene. The invention also discloses an application of the material in fluorescence imaging and electronic computed tomography imaging.

Description

technical field [0001] The invention relates to the technical field of nanobiological materials, in particular to a rare earth upconversion-bismuth diagnosis and treatment integrated nano-hybrid system, a preparation method and an application of light-responsive controllable drug release. Background technique [0002] In recent years, rare-earth upconversion nanofluorescent materials have become one of the research hotspots in bioimaging technology, due to their unique optical and chemical properties, such as sharp emission lines, long lifetime, high photostability and chemical stability sex. The upconversion luminescence (UCL) process involves the conversion of low-energy light in the near-infrared (NIR) region to high-energy light in the visible region through multiphoton absorption or energy transfer, which can eliminate the autofluorescence of biological tissues. However, near-infrared-excited fluorescence imaging has the disadvantages of being susceptible to interferen...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K49/04A61K47/69A61K41/00A61K31/704A61P35/00
CPCA61K31/704A61K41/0052A61K49/0002A61K49/0019A61K49/0093A61K49/04A61K47/6949A61P35/00A61K2300/00
Inventor 孙丽宁凌丹萍施利毅孙松强王卓
Owner SHANGHAI UNIV
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