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A turbot oil emulsified vaccine and its application

A technology of turbot oil and vaccine, which is applied in the field of microbiology and immunology of aquaculture animals, can solve the problems of large side effects, and achieve the effects of small side effects, high antibody titer, and high early immune protection effect

Active Publication Date: 2021-07-02
YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the problem of large side effects when the oil emulsified vaccine is used in the existing turbot, we propose a turbot oil emulsified vaccine and its application

Method used

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  • A turbot oil emulsified vaccine and its application
  • A turbot oil emulsified vaccine and its application
  • A turbot oil emulsified vaccine and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. Experiment preparation

[0029] 1. Experimental materials

[0030] The turbot used in the experiment was purchased from a farm in Yantai, Shandong, weighing 62.54g±9.75g. Breeding in the cement pond of the factory (7m×7m×1m), the water temperature is 16°C, feed and change water according to the normal management method: the daily feeding amount of feed is 1.2% to 1.5% of the body weight, feeding twice a day, changing daily The water volume is 6 pools. Two weeks before the experiment, the movement, feeding, and body surface of the turbot were observed. After confirming that there was no abnormality, 30 turbots were randomly selected, and the body surface and gills were observed with naked eyes and microscopes for parasitic infection. The liver, spleen, and Bacteria were isolated from kidney tissue, and after confirming that there was no bacterial and parasitic infection, it was used for subsequent experiments.

[0031] 2. Preparation of Vibrio anguillaris bivalent ...

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Abstract

The invention discloses a turbot oil emulsified vaccine, which is prepared by emulsifying the vaccine antigens Vibrio anguillarum O1 serotype strain VAM003 and O2 serotype strain VAM007 with Marcol 52 after emulsification. The invention also discloses the application of a turbot oil emulsified vaccine, the final concentration of the turbot vaccine used for immunization is 10 9 cells / ml, the concentration of injection immunization is 10 4 -10 8 CFU / g. The beneficial effect of the invention is that the invention can make the immune turbot obtain higher antibody titer and early immune protection effect; the side effect is extremely small, and the weight of the turbot has no significant impact on the production scale.

Description

technical field [0001] The invention relates to the field of microbiology and immunology of aquaculture animals, in particular to an oil emulsified vaccine of turbot and its application. Background technique [0002] Turbot belongs to the class of Osteophytes, Plaiceidae of the order Pleuriformes, the English name is Turbot, commonly known as European flatfish, and it is called "Turbofish" and "Acanthus flounder" in China. Native to the European Atlantic waters, it is one of the world-recognized high-quality flounder. [0003] The body is diamond-shaped, flat and tall, and the body length is 1.3 to 1.6 times the body height. Both eyes are located on the left side of the head, and the body length is up to 1M. Bare without scales, only the side of the eye is covered with bony protrusions smaller than the diameter of the eye. The mouth is large, the cusps of the jaws are thin and curved, and there are no canine teeth. Most rays of dorsal and anal fins branch. The side with ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K39/39A61K39/106A61P31/04
CPCA61K9/0019A61K9/107A61K39/107A61K39/39A61K2039/521A61K2039/552A61K2039/55566A61P31/04
Inventor 李杰莫照兰李贵阳阎永伟
Owner YELLOW SEA FISHERIES RES INST CHINESE ACAD OF FISHERIES SCI
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