A kind of traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine granules and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating a gastroesophageal reflux disease and traditional Chinese medicine granules as well as a preparation method thereof. Thetraditional Chinese medicine granules contain 100 parts by weight of traditional Chinese medicine extract, 50 parts by weight of dextrin and 8 parts by weight of ethanol solution. A traditional Chinese medicine extracting method comprises the following steps: taking 6 parts by weight of radix bupleuri, 12 parts by weight of fructus aurantii, 3 parts by weight of coptis chinensis, 3 parts by weight of fructus evodiae, 9 parts by weight of stir-baked fructus gardeniae, 9 parts by weight of herba inulae, 12 parts by weight of mangnolia officinalis, 15 parts by weight of rhizoma polygonati and 15parts by weight of calcined concha arcae, adding 10 times of water and extracting for three times, wherein the extracting time per time is 1.0 h; combining decoction liquid, filtering, concentratingand drying. The traditional Chinese medicine composition for treating the gastroesophageal reflux disease and the traditional Chinese medicine granules as well as the preparation method thereof disclosed by the invention have the benefits that an extraction process is optimized by adopting an orthogonal experiment method and a weighted analysis method, and the yield of optimized dry extracts and the contents of naringin and gardenin are determined, so that an optimum extraction process is obtained; a preparation process is further optimized by adopting a single-item screening method, and the molding rate, the solubility and the granulation difficulty of the granules prepared by the optimized process are investigated, so that an optimal preparation process is obtained.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating gastroesophageal reflux disease, traditional Chinese medicine granules and a preparation method thereof. Background technique [0002] Gastroesophageal reflux disease (GERD) is a common digestive tract motility disorder disease, which causes clinical gastroesophageal reflux disease and esophageal mucosa damage due to excessive exposure of the gastroesophageal lumen to gastric juice. Acid reflux, heartburn, retrosternal pain and other symptoms. The disease is very common in western countries. With the rapid development of my country's economy, people's living standards have improved, Chinese people's lifestyle and diet structure are gradually Westernized, and the population is aging. The prevalence of GERD is gradually increasing, and it is very easy to relapse. The goals of GERD treatment are to reliev...

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Problems solved by technology

In the prior art, there is no report about the traditional Chinese medicine granules for the treatment of gastroesophageal reflux disease of the present invention and the preparation method thereof.

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