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Method for determining content of phthalic acid in benzoic acid by adopting high performance liquid chromatography

A high-performance liquid chromatography, phthalic acid technology, applied in the field of analysis and detection, can solve the problems of inability to apply multiple samples, long-term quantitative analysis, inability to accurately quantitative analysis, poor applicability, etc., and achieve peak shape symmetry. Poor performance, stable baseline, optimized instrument conditions and the effect of

Inactive Publication Date: 2020-02-11
湖北科林博伦新材料有限公司
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Problems solved by technology

[0003] At present, there are not many methods and literatures for the determination of phthalic acid in benzoic acid. Although GB1886.183-2016 discloses the determination method of phthalic acid in benzoic acid in food additives, the applicability of the national standard method is not good, and the baseline fluctuates Large, making accurate quantitative analysis impossible, especially not suitable for multi-sample, long-term quantitative analysis

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  • Method for determining content of phthalic acid in benzoic acid by adopting high performance liquid chromatography
  • Method for determining content of phthalic acid in benzoic acid by adopting high performance liquid chromatography
  • Method for determining content of phthalic acid in benzoic acid by adopting high performance liquid chromatography

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Embodiment Construction

[0043] The present invention will be further described below in conjunction with the embodiments and accompanying drawings, but the protection scope of the present invention is not limited to the scope described in the embodiments.

[0044] Analytical method for determination of phthalic acid content in benzoic acid by high performance liquid chromatography

[0045] 1. Wavelength and mobile phase selection

[0046] 1.1 Wavelength selection

[0047] Use a UV-visible spectrophotometer to continuously scan phthalic acid methanol solution and benzoic acid methanol solution at 190nm-810nm, and phthalic acid has a maximum absorption at 226nm (see figure 1 , figure 2 ), benzoic acid has a maximum absorption at 224nm (see image 3 , Figure 4 ). The measurement wavelength used in the national standard GB1886.183-2016 is 228nm.

[0048] After detection and comparison of the maximum absorption wavelength of phthalic acid and the corresponding absorption spectrum, see Figure 5 ,...

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Abstract

The invention discloses a method for determining content of phthalic acid in benzoic acid by adopting high performance liquid chromatography, and particularly relates to an analysis method for quantitatively analyzing the content of phthalic acid by adopting a methanol-buffer salt mixed solution system and an external standard method. The chromatographic conditions of the method are as that: a chromatographic column is Poroshell 120 EC-C18 with the specifications of 4.6 mm*150 mm and 4-Micron; a mobile phase is prepared from methanol and 0.03 mol / L buffer salt in a volume ratio of 20:80; a flow rate is 1 mL / min; a detection wavelength is 230 nm; a column temperature is 30 DEG C; and a sample injection volume is 20 mu L. The method has the advantages of simple sample treatment and analysisprocess, high analysis result precision, good reproducibility and the like.

Description

technical field [0001] The invention relates to the field of analysis and detection, in particular to a method for measuring the content of phthalic acid in benzoic acid by using high performance liquid chromatography. Background technique [0002] Phthalic acid (C 8 h 6 o 4 ) is one of the isomers of phthalic acid, and the two carboxyl groups on the benzene ring are in the ortho position. It has two isomers: isophthalic acid and terephthalic acid. Phthalic acid is mainly used to produce phthalic anhydride, a precursor for the production of chemicals such as dyes, perfumes, saccharin, phthalates, and phenolphthalein. [0003] At present, there are not many methods and literatures for the determination of phthalic acid in benzoic acid. Although GB1886.183-2016 discloses the determination method of phthalic acid in benzoic acid in food additives, the applicability of the national standard method is not good, and the baseline fluctuates Large, resulting in the inability of...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/06G01N30/74
CPCG01N30/06G01N30/74
Inventor 潘中华宛捍东骆凯刘冬梅
Owner 湖北科林博伦新材料有限公司
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