Poisoning-resistant water-soluble peroxide decomposition catalyst as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of application of functional coordination compounds and in particular relates to a poisoning-resistant water-soluble peroxide decomposition catalyst as well as preparation and application thereof. In the water-soluble peroxide decomposition catalyst, a metal center is protected by a ligand in a catalysis process and does not directly react with a substrate and other impurities, so that the possibility of deactivation caused by poisoning is avoided; polar groups such as a sulfonic group, a carboxylic group and hydroxyl on the outer layer of a designed electronic sponge type catalysis center can endow a corresponding coordination compound with very good water solubility, and also can participate in an elementary reaction in which the polar groupsare transferred along with protons and electrons; when the electronic sponge type catalysis center reacts with the substrate, the electrons can be transferred through an outer-layer electron transferring mechanism by using electronic properties of delocalization so as to realize the aim of oxidation reduction; and an experiment proves that this coordination compound has a very good catalytic capability on peroxide decomposition, and is expected to become one type of catalyst or metal drug practical in the field of biochemical drugs.

Description

technical field [0001] The invention belongs to the technical field of application of functional complexes, and specifically relates to the preparation of water-soluble metal complex catalysts by tridentate Non-innocent ligands with redox activity and its preparation method and application. Background technique [0002] Catalase (CAT) can catalyze H 2 o 2 Decomposed into non-toxic water and oxygen, its unique high-efficiency catalytic performance is of great significance to disease treatment, anti-aging, health care and beauty, food industry, textile printing and dyeing, paper industry and other aspects. However, natural enzymes have the characteristics of large molecular weight, poor cell permeability, easy inactivation, difficult extraction, and high cost. Therefore, it is particularly important to synthesize catalysts with natural antioxidant enzyme functions. [0003] In the current design of peroxide decomposition catalysts, many are designed based on the active cente...

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Problems solved by technology

[0004] At present, the research on peroxide decomposition catalysts mainly focuses on heterogeneous noble metal catalysts (gold, silver, palladium, osmium, platinum) and metal oxide catalysts (MnO 2 , Fe 2 o 3 , CeO 2 、Gd 2 o 3 etc.), in the research of homogeneous catalysts, mainly including Schiff base (Schiff base), Salen, porphyrin, macrocyclic polyamine, and phthalocyanine (MPc) and other small molecule metal complexes, all Phase catalysts are easily poisoned and inactivated by impurities or other interference factors due to the exposed metal centers, and at the same time, the exposed metal centers are easy to interact with amino acid residues in the organism or form m-O bridge agglomerations, which can easily lead to biological toxicity

In real life, in addition to industrial applications, peroxide decomposition catalysts can also be applied to the field of biomedical drugs, such as the treatment of catalase deficiency as a metal drug, and the removal of hydrogen peroxide used in the manufacture of cheese in the food industry , cleaning solution in contact lenses, cancer cell oxygenizer in cancer treatment, etc., but if these applications are to be satisfied, the corresponding catalyst needs to meet low toxicity or non-toxicity in addition to good catalytic effect. Toxicity, good water solubility, but studies that take into account these characteristics have not been reported

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