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Preparation method of melt electrospun composite fiber scaffold for bone repair and anti-infection

A composite fiber, anti-infection technology, applied in the fields of fiber chemical characteristics, prosthesis, rayon manufacturing, etc., can solve problems such as susceptibility to infection, and achieve the effect of solving infection, accelerating bone repair, and improving hydrophobicity

Active Publication Date: 2020-01-10
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In view of this, the purpose of the present invention is to provide a method for preparing a melt-electrospun composite fiber scaffold for bone repair and anti-infection, which can solve the problem that existing bone repair implants require secondary surgery to remove and are susceptible to infection. problems, and at the same time, it can promote bone cell proliferation and accelerate bone repair

Method used

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  • Preparation method of melt electrospun composite fiber scaffold for bone repair and anti-infection
  • Preparation method of melt electrospun composite fiber scaffold for bone repair and anti-infection
  • Preparation method of melt electrospun composite fiber scaffold for bone repair and anti-infection

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preparation example Construction

[0030] The invention provides a method for preparing a melt electrospun composite fiber scaffold for bone repair and anti-infection, comprising the following steps:

[0031] a) Mix polycaprolactone, polyethylene glycol and macrolide antibiotics uniformly in an organic solvent, evaporate the organic solvent and dry in vacuum to obtain a solid mixed material; the polycaprolactone, polyethylene glycol and macrolide The mass ratio of cyclic lactone antibiotics is 90:(0.1~20):(0.1~20);

[0032] b) Melt electrospinning the solid mixed material obtained in step a) to obtain a melt electrospun composite fiber scaffold for bone repair and anti-infection.

[0033] In the invention, polycaprolactone, polyethylene glycol and macrolide antibiotics are uniformly mixed in an organic solvent, evaporated to evaporate the organic solvent, and then vacuum-dried to obtain a solid mixed material. The present invention has no special limitation on the sources of the polycaprolactone (PCL) and poly...

Embodiment 1

[0067] (1) be that 90% PCL by mass percentage composition, 5% PEG and 5% Roxithromycin by mass percentage composition are put into Erlenmeyer flask, raw material total mass is 5g; Add 30mL of organic solvent tetrahydrofuran, then stir in a magnetic stirrer at a temperature of 50°C and a speed of 400r / min for 24h, then pour the uniformly mixed material into a glass dish, and place it in a fume hood for 4h to evaporate the organic solvent tetrahydrofuran , and then put the glass dish containing the material into a vacuum drying oven at 80° C. for 3 hours to dry. After drying, take it out and let it stand for cooling to obtain a solid mixed material of PCL, PEG and roxithromycin.

[0068] (2) The solid mixed material obtained in step (1) is carried out to melt electrospinning, and the specific process is as follows:

[0069] Cut the solid mixed material into pieces with scissors and put it into the barrel; take a needle with an inner diameter of 0.45 mm, wash it with clean water ...

Embodiment 2

[0076] Using the same procedure as in Example 1, PCL with a mass percentage of 85%, PEG with a mass percentage of 10% and roxithromycin fiber scaffold with a mass percentage of 5% were prepared.

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Abstract

The invention provides a preparation method of a melt electrospun composite fiber scaffold for bone repair and anti-infection. The preparation method comprises the following steps that (a) polycaprolactone, polyethylene glycol and macrolide antibiotics are mixed uniformly in an organic solvent, the organic solvent is evaporated and then is subjected to vacuum drying, and a solid mixed material isobtained; the mass ratio of the polycaprolactone to the polyethylene glycol to the macrolide antibiotics is 90 to (0.1-20) to (0.1-20); and (b) the solid mixed material obtained in the step (a) is subjected to melt electrospinning, and the melt electrospun composite fiber scaffold for the bone repair and anti-infection is obtained. Compared with the prior art, the preparation method can obtain a novel bone repair and anti-infective melt electrospun composite fiber scaffold which has an ordered structure and excellent biocompatibility, can be completely degraded, can be antibacterial, can promote bone cell proliferation, and meet the physical performance requirements, and the problems that a bone repair implant requires to be removed surgically twice and the bone implant is infected are solved.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a method for preparing a melt electrospun composite fiber scaffold for bone repair and anti-infection. Background technique [0002] Orthopedic and orthopedic surgery infections account for 15% of all hospital infections. Implant-related bone infections (septic arthritis and osteomyelitis) occur in 5% of the 2 million fracture fixation cases per year in the US, costing $15,000 to $50,000 per event. Several steps are usually followed in the treatment of bone infections: Treatment usually goes through several stages: local drainage, debridement of necrotic tissue, management of bone dead space, soft tissue coverage, and restoration of blood supply. Among them, the management of the bone dead area is the most important step. Effective management of the bone dead area can effectively prevent the reinfection of the bone defect and the physical integrity of the bone tissue, and p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/58A61L27/18A61L27/54D01F8/14D01F8/16D01F1/10
CPCA61L27/18A61L27/54A61L27/58A61L2300/216A61L2300/404A61L2430/02D01F1/103D01F8/14D01F8/16C08L67/04C08L71/02
Inventor 白见福王晗汤亚东梁峰汪子煦蓝兴梓周颖苗小敏
Owner GUANGDONG UNIV OF TECH
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