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Preparation method of dendrobium instant freeze-dried blocks

A dendrobium and instant technology, which is applied in the direction of freeze-dried transportation, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of less dissolution of active ingredients, influence on taking, and easy to stick into agglomerates, etc. Achieve broad market application prospects, low residual moisture, excellent resolubility and instant effect

Active Publication Date: 2019-12-13
厦门涌泉科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both Xianpin and Fengdou have disadvantages such as inconvenient administration, less dissolution of active ingredients and low bioavailability
Dendrobium contains a large amount of mucopolysaccharide and cellulose components, which are not easy to disperse, and it is easy to stick into agglomerates when mixed with boiling water, which affects its intake.
CN101700361A discloses a kind of Dendrobium candidum instant powder and preparation method thereof, said fresh Dendrobium candidum is added with water to extract juice, then freeze-dried or spray-dried and then added auxiliary materials to prepare Dendrobium candidum instant powder, the method prepares Dendrobium instant powder and its resolubility Low, and bubbling, peeling, and fracture have occurred during the freeze-drying process, which affects its freeze-drying efficiency
CN104056069A discloses a preparation method of a dendrobium broken wall preparation, the broken wall of the dendrobium is crushed and then granulated and dried to obtain a dendrobium broken wall preparation. The preparation is easily sticky when mixed with boiled water, and the solubility is not good
CN104623312A discloses a kind of dendrobium instant powder, its preparation method and application. The fresh dendrobium candidum is homogenized with water, sprayed and dried with auxiliary materials and then granulated to obtain dendrobium instant powder. The higher the volatility of heat-sensitive substances and the loss of active ingredients, the color will change, and the solubility in water is not good enough. In order to keep the original volume and shape of the product after drying, it can be dissolved quickly and completely after adding water. , in the drying process, it is often necessary to add a certain amount of excipients to maintain the porous solid structure of the freeze-dried product

Method used

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  • Preparation method of dendrobium instant freeze-dried blocks
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  • Preparation method of dendrobium instant freeze-dried blocks

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Remove the leaves of the fresh dendrobium raw material, wash and cut into 1-2cm segments;

[0031] (2) Place the above-mentioned small section in a wall-breaking device, mix it with 10 times the volume of distilled water, and break the wall at a speed of 30,000 rpm for 1 min;

[0032] (3) The material obtained in step (2) is filtered by a three-legged centrifugal filter, and its rotating speed is 500~800rpm;

[0033] (4) Place the solid obtained in step (3) in a high-speed dispersion device, and disperse for 3 minutes at a speed of 8000 rpm;

[0034] (5) The material obtained in step (4) is placed in a high-pressure homogenization device for high-pressure homogenization twice, and each high-pressure homogenization includes the first homogenization and the second homogenization successively, wherein the pressure of the first homogenization 400Bar, the second homogeneous pressure is 1500Bar;

[0035] (6) add 5wt% lactose in the material of step (5) gained;

[0036]...

Embodiment 2

[0042] (1) Remove the leaves of the fresh dendrobium raw material, wash and cut into 1-2cm segments;

[0043](2) Place the above-mentioned small section in a wall-breaking device, mix it with 10 times the volume of distilled water, and break the wall at a speed of 30,000 rpm for 1 min;

[0044] (3) The material obtained in step (2) is filtered by a three-legged centrifugal filter, and its rotating speed is 500~800rpm;

[0045] (4) Place the solid obtained in step (3) in a high-speed dispersion device, and disperse for 3 minutes at a speed of 8000 rpm;

[0046] (5) The material obtained in step (4) is placed in a high-pressure homogenization device for high-pressure homogenization twice, and each high-pressure homogenization includes the first homogenization and the second homogenization successively, wherein the pressure of the first homogenization 400Bar, the second homogeneous pressure is 1500Bar;

[0047] (6) add 5wt% sucrose in the material of step (5) gained;

[0048] ...

Embodiment 3

[0054] (1) Remove the leaves of the fresh dendrobium raw material, wash and cut into 1-2cm segments;

[0055] (2) Place the above-mentioned small section in a wall-breaking device, mix it with 10 times the volume of distilled water, and break the wall at a speed of 30,000 rpm for 1 min;

[0056] (3) The material obtained in step (2) is filtered by a three-legged centrifugal filter, and its rotating speed is 500~800rpm;

[0057] (4) Place the solid obtained in step (3) in a high-speed dispersion device, and disperse for 3 minutes at a speed of 8000 rpm;

[0058] (5) The material obtained in step (4) is placed in a high-pressure homogenization device for high-pressure homogenization twice, and each high-pressure homogenization includes the first homogenization and the second homogenization successively, wherein the pressure of the first homogenization 400Bar, the second homogeneous pressure is 1500Bar;

[0059] (6) adding 5wt% glucose to the material obtained in step (5);

[...

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Abstract

The invention discloses a preparation method of dendrobium instant freeze-dried blocks. The preparation method comprises the following steps: (1) cleaning and cutting fresh dendrobium raw materials into sections; (2) performing high-speed wall breaking; (3) performing centrifugal filtration; (4) performing high-speed dispersion; (5) carrying out high-pressure homogenization; (6) adding a freeze-drying protective agent; (7) performing freeze drying; and (8) performing packaging. According to the invention, an excipient is added, so that a porous structure of the product is kept, and the dendrobium instant freeze-dried block has better redissolution, instant dissolution, uniform dispersion and smooth taste, has the characteristics of long quality guarantee period, good quality, redissolutionat low temperature and convenience in carrying, and has a wide market application prospect.

Description

technical field [0001] The invention belongs to the technical field of food processing, and in particular relates to a preparation method of dendrobium instant freeze-dried blocks. Background technique [0002] Dendrobium is a herbaceous plant belonging to the genus Dendrombium of Orchidaceae. It is sweet and light in taste, slightly cold in nature, and has the effects of nourishing yin, clearing heat, nourishing the stomach and promoting body fluid. The 2015 edition of the Chinese Pharmacopoeia included Dendrobium officinale and Dendrobium (source Dendrobium nobile, Dendrobium drumstick, and Dendrobium fringe). Dendrobium has the effect of "mainly treating the injury, eliminating numbness, lowering qi, nourishing the five viscera, strengthening the yin, thickening the stomach, lightening the body and prolonging life". As one of the traditional precious Chinese medicinal materials, Dendrobium has the reputation of "the first of the nine Chinese celestial herbs" among the pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8984A61K9/19A61K47/26A61P39/06A61P37/04A61P3/10A61P39/00A61P35/00A61P1/14A23L33/00
CPCA61K36/8984A61K9/19A61K47/26A61P39/06A61P37/04A61P3/10A61P39/00A61P35/00A61P1/14A23L33/00A23V2002/00A61K2236/15A61K2236/17A23V2200/302A23V2200/324A23V2200/308A23V2200/328A23V2200/32
Inventor 汤须崇黄志宏黄永恒赖鹭挺苏兴添郑丹玉赵丽茹
Owner 厦门涌泉科技有限公司
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