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Composition with anti-constipation effect, preparation method and application thereof

A composition and constipation technology, applied in the field of biomedicine, can solve problems such as unfavorable improvement of gastrointestinal motility, impact on appearance and taste, high incidence of abdominal distension, etc.

Active Publication Date: 2020-10-23
麦孚营养科技(北京)有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] At present, the commercially available compositions with the effect of preventing and treating constipation have the following defects: (1) inulin causes a higher incidence of abdominal distension in users who take them; It can play a role in regulating the balance of intestinal flora, and has a high incidence of abdominal distension; (3) Lactulose is converted into low molecular weight organic acids by the digestive tract flora in the colon, resulting in a decrease in the pH value of the intestinal tract and increasing gas production in patients After taking it, it is easy to have adverse reactions such as flatulence and abdominal discomfort
This product has the following defects: First, the product combines inulin, fructooligosaccharides, polydextrose, xanthan gum and other ingredients, the product ingredients are complex, and there is no targeted selection of dietary fiber ratios suitable for different constipation groups , the preparation cost is relatively high; the second is that inulin is a linear straight-chain polysaccharide formed by fructose linked by β(2-1) bonds, often with a glucose at the end, and the degree of polymerization is usually 2-60
This product has two major defects: one is that it needs to be used together with dairy products (such as milk, lactic acid beverages, formula milk powder, cheese, etc.), and patients with organic constipation often show intolerance to dairy products, resulting in a high incidence of abdominal distension The second is that the dietary fiber content in the product is low, which is not conducive to improving gastrointestinal motility, and the effect of improving constipation is limited.
[0026] Currently, the marketed constipation treatment drugs or compositions have the following defects: (1) limited indications, many application contraindications, limited applicable population and application methods, especially not suitable for patients with tumor-related constipation; (2) not easily (3) The content of dietary fiber is insufficient, it is difficult to meet the clinical needs of enhancing gastrointestinal motility of patients, and it is prone to repeated constipation symptoms; (4) The product does not effectively improve the composition and balance of intestinal flora (5) The lactulose contained in the product is converted into low-molecular-weight organic acids by the digestive tract flora in the colon, which leads to a decrease in the pH value of the intestinal tract and increases the frequency of gas production in patients. Cause adverse reactions such as flatulence and abdominal discomfort in the users; (6) Poor clarity of the product, which affects the appearance and taste of the product, and affects the patient's compliance with taking it

Method used

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  • Composition with anti-constipation effect, preparation method and application thereof
  • Composition with anti-constipation effect, preparation method and application thereof
  • Composition with anti-constipation effect, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Example 1 Composition and proportioning research of the composition of the present invention

[0111] Weigh required amounts of the first polymer and the second polymer according to Table 1, wherein the total number of parts of the first polymer and the second polymer is 40 parts, add 60 parts of water, stir and dissolve to prepare the composition.

[0112] A total of 130 patients with cancer chemotherapy-related constipation were selected, regardless of gender. The age range of the subjects was 40-60 years old. It was required that they had no intestinal diseases within one month and did not take antibiotics, microecological drinks or health care medicines.

[0113] 130 patients were randomly divided into 13 groups, 10 cases in each group. Among them, the 12th group is the experimental group, and the test patients take the composition A-L respectively, and the dosage is 2 times / day, each time 15g, for 14 consecutive days; the 13th group is the blank control group, and...

Embodiment 2

[0123] Example 2 Raw material ratio research experiment of the composition of the present invention

[0124] Weigh the required amount of the first polymer and the second polymer according to Table 2, the total number of parts of the first polymer and the second polymer is 40 parts, add 60 parts of water, stir and dissolve, and prepare the composition.

[0125] Select 100 test patients with constipation related to tumor chemotherapy, regardless of sex, the age range of the patients is 40-60 years old, the test patients have no intestinal diseases within 1 month, and have not taken antibiotics, probiotic drinks or health medicine.

[0126] 100 test patients were randomly divided into 10 groups, 10 cases in each group. Among them, group 9 is the test group, taking compositions 1-9 respectively, the dosage is 2 times / day, 15g each time, and taking for 14 consecutive days; group 10 is the blank control group, and the test patients take the same amount of Water without taking a...

Embodiment 3

[0135] Example 3 Sensory evaluation experiment of the composition of the present invention

[0136] A total of 90 patients aged 40-60 with constipation symptoms were selected, including 30 patients with constipation caused by cancer chemotherapy, 30 patients with chronic constipation and 30 patients with constipation caused by enteral nutrition.

[0137] 90 subjects took the composition 3 of the present invention respectively, the dosage was 2 times / day, 15g each time, for 14 consecutive days. See Table 3 for the sensory evaluation test results of the composition of the present invention.

[0138] The sensory evaluation experiment of table 3 composition of the present invention

[0139]

[0140]

[0141] It can be seen from Table 3 that the composition of the present invention has good flavor and mouthfeel, suitable dosage, and is suitable for preventing and treating various types of constipation.

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Abstract

The invention relates to a composition with a constipation prevention and treatment effect, and a preparation method and an application thereof. Effective components in the composition are a first polymer and a second polymer, wherein the first polymer and the second polymer are obtained through glycosidic bond polymerization of monosaccharide and / or uronic acid of monosaccharide, the polymerization degree of the first polymer is an integer of 2-100, the polymerization degree of the second polymer is an integer of 10-3000, and the mass ratio of the first polymer to the second polymer is 1:3-1:6. The composition disclosed by the invention is suitable for tumor-associated diarrhea, has a bidirectional regulation effect on constipation and diarrhea, and can be taken for a long time.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a composition with the effect of preventing and treating constipation, a preparation method thereof and an application thereof. Background technique [0002] Constipation is a common digestive system disease. Normal people defecate 1-2 times a day or once every 1-2 days. Constipation patients often show symptoms such as induration of stool, difficulty in defecation, laborious defecation, incomplete defecation, induration and small amount of stool, and decreased frequency of defecation (≤3 times / week). Surveys show that constipation can occur in people of any age and any occupation, and the incidence rate of constipation is as high as 20%-30% (Wang Jiyao. Internal Medicine [M]. 2nd Edition. Beijing: People's Medical Publishing House, 2011:479.). [0003] Constipation is one of the common complications of cancer patients. About 40% of end-stage cancer patients will experience constipa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7088A61K31/715A61K31/733A61K31/716A61K31/732A61P1/10A61P1/12A61P35/00
CPCA61K31/7088A61K31/715A61K31/716A61K31/732A61K31/733A61P1/10A61P1/12A61P35/00A61K2300/00
Inventor 郭伟
Owner 麦孚营养科技(北京)有限公司
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