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Skin wound repairing ointment and preparation method thereof

A skin wound and ointment technology, which is applied in the field of biomedicine to achieve the effects of promoting wound healing, fast digestion and absorption, and low molecular weight

Pending Publication Date: 2019-12-06
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, researchers have begun to pay attention to marine active substances that help wound healing, such as krill trypsin, collagenase, sea cucumber polysaccharides, fish polypeptides, marine collagen peptides, and mussel decorin. Skin and soft tissue wound healing active substances from rare marine shellfish

Method used

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  • Skin wound repairing ointment and preparation method thereof
  • Skin wound repairing ointment and preparation method thereof
  • Skin wound repairing ointment and preparation method thereof

Examples

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Embodiment 1

[0047] This embodiment provides a skin wound repair ointment, which is characterized in that it includes the following components in parts by weight: lanolin 22, white petrolatum 44, glycerin 22, marine shellfish active peptide 4, collagen peptide 0.2, water 3;

[0048] The marine shellfish active peptide is an enzymatic hydrolysis product of the mantle of marine shellfish;

[0049] The collagen peptide is an enzymatic hydrolysis product of Collagena graminis.

[0050] Further, the raw material for the preparation of the marine shellfish active peptide is Pinctada martensii.

[0051] Further, the preparation method of the marine shellfish active peptide is:

[0052] A1. Preparation of marine shellfish enzymatic hydrolyzate;

[0053] The marine shellfish mantle is separated by pretreatment; the protease selected for enzymatic hydrolysis of the marine shellfish mantle is animal protease, the amount of protease added is 4000U / g, the pH value is 7.5, the enzymolysis temperature ...

Embodiment 2

[0065] This embodiment provides a skin wound repair ointment, which is characterized in that it includes the following components in parts by weight: lanolin 20, white petrolatum 40, glycerin 20, marine shellfish active peptide 2, collagen peptide 0.1, water 1;

[0066] The marine shellfish active peptide is an enzymatic hydrolysis product of the mantle of marine shellfish;

[0067] The collagen peptide is an enzymatic hydrolysis product of Collagena graminis.

[0068] Further, the raw material for the preparation of the active peptide from marine shellfish is Chlamys chinensis.

[0069] Further, the preparation method of the marine shellfish active peptide is:

[0070] A1. Preparation of marine shellfish enzymatic hydrolyzate;

[0071] The mantle of marine shellfish is separated by pretreatment; the protease selected for enzymatic hydrolysis of the mantle of marine shellfish is neutral protease, the amount of protease added is 3000U / g, the pH value is 6.5, the enzymatic hyd...

Embodiment 3

[0083] This embodiment provides a skin wound repair ointment, which is characterized in that it includes the following components in parts by weight: lanolin 25, white petrolatum 50, glycerin 25, marine shellfish active peptide 6, collagen peptide 0.3, water 5;

[0084] The marine shellfish active peptide is an enzymatic hydrolysis product of the mantle of marine shellfish;

[0085] The collagen peptide is an enzymatic hydrolysis product of Collagena graminis.

[0086] Further, the raw material for the preparation of the active peptide from marine shellfish is scalloped shellfish.

[0087] Further, the preparation method of the marine shellfish active peptide is:

[0088] A1. Preparation of marine shellfish enzymatic hydrolyzate;

[0089] The mantle of marine shellfish is separated by pretreatment; the protease selected for enzymatic hydrolysis of the mantle of marine shellfish is alkaline protease, the amount of protease added is 5000U / g, the pH value is 10, the enzymolysis...

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Abstract

The invention provides a skin wound repairing ointment, which is characterized in comprising the following ingredients in parts by weight: 20-25 parts of wool grease, 40-50 parts of albolene, 20-25 parts of glycerol, 2-6 parts of marine mollusk active peptide, 0.1-0.3 part of collagen peptide and 1-5 parts of water, wherein the marine mollusk active peptide is a marine mollusk mantle enzymolysis product, and the collagen peptide is a sipunculus nudus collagen enzymolysis product. The skin wound repairing ointment has the efficacies on resisting bacteria, diminishing inflammation, removing slough, promoting growth of tissue regeneration, astringing, healing and inhibiting scar hypertrophy and is especially suitable for wound healing and reducing remaining scars.

Description

technical field [0001] The invention belongs to the field of biomedical technology, and more specifically relates to a skin wound repair ointment and a preparation method thereof. Background technique [0002] Human injury caused by various traumas, burns, surgery and other reasons is a common clinical phenomenon. According to the statistics of the World Health Organization, in 1990, the number of deaths due to various traumas in the world was 5.1 million, and it is expected to reach 8.4 million in 2020. Therefore, trauma is a disease that cannot be ignored. Among them, skin trauma and skin repair barriers are not only prone to infection and the possibility of related complications, but also seriously affect the quality of life of patients. Therefore, the development of bio-based wound repair techniques with rapid healing and no scars is one of the focus and hotspots of surgical research. Skin and soft tissue wound healing is a dynamic and coordinated tissue repair proc...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K9/06A61K47/44A61K47/06A61P17/02
CPCA61K38/014A61K38/012A61K9/06A61K9/0014A61K47/44A61K47/06A61P17/02
Inventor 林海生秦小明章超桦杨发明张婷
Owner GUANGDONG OCEAN UNIVERSITY
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