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Detection method of caesalpinia decapetala cold mixture

A technology of Yunshi Ganmao mixture and detection method, which can be applied to antiviral agents, measuring devices, drug combinations, etc., can solve the problems of inconvenient transportation and carrying, unstable quality, and poor taste of the original dosage form.

Active Publication Date: 2019-12-03
GUIZHOU LIANGJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, through the study of its dosage form, it was found that the taste of the original dosage form is not good, the quality control standard is simple, the product quality is unstable, and the transportation is inconvenient.
This product provides a Yunshi traditional Chinese medicine preparation for the treatment of colds, in order to overcome the disadvantages of the original mixture, such as bad taste, simple quality control standards, easy precipitation, unstable quality, and inconvenient transportation, etc., making the preparation process more perfect

Method used

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  • Detection method of caesalpinia decapetala cold mixture
  • Detection method of caesalpinia decapetala cold mixture
  • Detection method of caesalpinia decapetala cold mixture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Yunshi Ganmao Mixture is prepared from the following raw material weight ratios:

[0111]

[0112] The above-mentioned Yunshi Ganmao mixture is prepared according to the following method: extract the volatile oil from the above four medicinal materials and ginger, distill and collect the aqueous solution in a separate device, decoct the medicinal residue and the other three flavors such as Yunshipi with water for three times, the first time for 2 hours, The second and third times are 1.5 hours each, and the decoctions are combined and filtered. Combine the filtrate with the distilled aqueous solution, concentrate to a clear paste with a relative density of 1.18-1.22 (50°C), add ethanol until the alcohol content is 75%, mix well, let stand for 24 hours, filter, and recover ethanol from the filtrate. Add brown sugar, sodium benzoate, ethyl p-hydroxybenzoate, polysorbate 80 and ginger volatile oil, mix well, add water to the specified amount, let it stand for 24 hours, ...

Embodiment 2

[0129] Example 2. Yunshi Ganmao Mixture is prepared from the following raw material weight ratios:

[0130] The prescription and preparation method of Yunshi Ganmao mixture are as in Example 1.

[0131] Properties of this product: This product is a brownish-red liquid; the air is slightly gingery, and the taste is slightly sweet and then bitter and astringent.

[0132] The detection method of Yunshimao mixture of the present invention comprises the determination of (±) prohematoxylin B content in Yunshipi.

[0133] In the detection method of aforementioned Yunshimao mixture, the content determination of (±) prohematoxylin B in Yunshipi is determined by Chinese Pharmacopoeia HPLC method, and the specific method is as follows:

[0134] ① Chromatographic conditions and system suitability test

[0135] Chromatographic column: Shimadzu GL Inertsil ODS-SP C18 column: 4.6×250mm, 5μm; ZORBAX EclipsePlus C18: 4.6×250mm, 5μm; mobile phase: acetonitrile: 0.2% acetic acid = 10~20: 80~9...

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Abstract

The invention discloses a detection method of a caesalpinia decapetala cold mixture. The detection method comprises a step of measuring content of (+ / -) Protosappanin B in cortex caesalpiniae radices.The detection method is accurate, has high sensitivity and repeatability, delivers a stable detection result, and can effectively detect quality of the caesalpinia decapetala cold mixture. Detectionitem standards can guarantee drug effect.

Description

technical field [0001] The invention relates to a detection method of Yunshi Ganmao mixture, which belongs to the field of drug detection technology. Background technique [0002] A cold is an upper respiratory tract infection caused by cold viruses invading the human body. Its clinical symptoms are fever, runny nose, sneezing, nasal congestion, headache, cough, sore throat, tonsil enlargement and general malaise; the principle of treatment is antibacterial (viral ) anti-inflammatory, antipyretic and pain-relieving, antitussive and expectorant. The Yunshi Ganmao mixture developed by the applicant has been clinically used for many years, and has been recognized and welcomed by the majority of patients. It has a solid clinical foundation, has no toxic and side effects, and has definite curative effects. In December 2002, the local standard of Guizhou Province was raised to the national standard ( No content determination), in 2003 by the State Food and Drug Administration as ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06A61K36/9068A61P11/00A61P31/16
CPCG01N30/02G01N30/06A61K36/48A61K36/73A61K36/85A61K36/9068A61K9/0095A61P11/00A61P31/16A61K2300/00
Inventor 张永萍徐剑杨星
Owner GUIZHOU LIANGJI PHARMA
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