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Application of nuciferine and lotus leaf extract in preparation of drug for treating atrophic gastritis and/or blocking gastritis cancer conversion

A technology of lotus leaf extract and atrophic gastritis, which is applied in the field of natural small molecule compounds of traditional Chinese medicine and traditional Chinese medicine extracts, and can solve the problems of reports of undiscovered therapeutic effects, etc.

Active Publication Date: 2019-11-01
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cancer transformation of enteritis and cancer transformation of gastritis are two distinct disease processes. Literature research has not found reports on the therapeutic effects of nuciferine and lotus leaf extract on gastric cancer, gastric precancerous lesions, and gastritis cancer transformation caused by gastritis.

Method used

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  • Application of nuciferine and lotus leaf extract in preparation of drug for treating atrophic gastritis and/or blocking gastritis cancer conversion
  • Application of nuciferine and lotus leaf extract in preparation of drug for treating atrophic gastritis and/or blocking gastritis cancer conversion
  • Application of nuciferine and lotus leaf extract in preparation of drug for treating atrophic gastritis and/or blocking gastritis cancer conversion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Example 1: Nuciferine has the effect of treating chronic atrophic gastritis rats with intestinal metaplasia

Embodiment approach

[0061] Implementation scheme: The experimental animals were from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. Select 30 specific pathogen free (SPF) grade 200±20g SD rats, half male and half male, and randomly divide them into 5 groups: normal control group, chronic atrophic gastritis (CAG) model group, The positive drug celecoxib intervention group and the two-dose intervention group of nuciferine, 6 rats in each group. Nuciferine was purchased from Chengdu Ruifensi Biotechnology Co., Ltd., with a specification of 5g and a purity of over 98%. Celecoxib was purchased from Beijing Bailingwei Technology Co., Ltd., brand J&K, with a specification of 1 g and a purity of over 98%. Sodium deoxycholate was purchased from Amresco, USA, with a specification of 100 g. Rats in model group, celecoxib intervention group and nuciferine intervention group were given sodium deoxycholate solution and ammonia water to induce chronic atrophic gastritis in rats. 20mmol / L sodi...

Embodiment 2

[0073]Example 2: Lotus leaf extract has the effect of treating chronic atrophy with dysplasia in rats with gastritis. Experimental protocol: The experimental animals are from Beijing Speifu Biotechnology Co., Ltd. Select 24 specific pathogen free (SPF) 200±20g SD rats, half male and half male, and randomly divide them into 4 groups: normal control group, chronic atrophic gastritis (CAG) model group, lotus leaf Two doses of extract intervention groups, 6 rats in each group, as shown in Table 2. The lotus leaf extract was purchased from Hebei Chenguang Biotechnology Group Handan Co., Ltd., specification: 1kg, and the content of nuciferine was above 0.4%. Sodium deoxycholate was purchased from American Amresco Company, specification 100g. Rats in the model group and the lotus leaf extract intervention group were given sodium deoxycholate solution, ammonia water and ethanol to induce chronic atrophic gastritis in the rats. Daily gavage of 20mmol / L sodium deoxycholate and 60% eth...

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Abstract

The invention provides application of a substance in preparation of a product for treating chronic atrophic gastritis, protecting gastric mucosa, treating lesion before gastric cancer, blocking gastric cancer conversion and preventing gastric cancer. The product is one of drugs, healthcare products and food and is selected from nuciferine, a derivate of nuciferine, a lotus leaf extract as well asa mixture of at least two of the substances. The application comprises at least one of treating chronic atrophic gastritis, protecting gastric mucosa, treating lesion before gastric cancer, blocking gastric cancer conversion and preventing gastric cancer. In-vitro experiments indicate that nuciferine can block gastritis cancer conversion cell proliferation. In-vivo experiments indicate that the nuciferine and the lotus leaf extract can treat rat atrophic gastritis (particularly chronic atrophic gastritis accompanied with intestinal metaplasia or dysplasia), protecting rats from gastric mucosallesion and inhibiting abnormal proliferation of stem cells of gastrointestinal tracts of fruit flies. Clinic tests prove that the lotus leaf extract can improve symptoms and indexes of atrophic gastritis or lesion before gastric cancer.

Description

technical field [0001] The invention belongs to the field of natural small molecular compounds of traditional Chinese medicine and traditional Chinese medicine extracts, and specifically relates to the preparation of nuciferine and lotus leaf extract as medicines and health products for treating chronic atrophic gastritis, treating gastric precancerous lesions and / or blocking the occurrence of gastritis cancer transformation , Food applications. Background technique [0002] Chronic inflammation is closely related to tumorigenesis [1]. Current epidemiological investigations and a number of scientific research results show that, in addition to genetic factors, most tumors are also closely related to environmental factors and lifestyles, such as smoking, diet, and infection. These carcinogenic factors can lead to different forms of cancer. Chronic inflammation, rather than controlled inflammation, contributes to tumorigenesis [2,3]. In particular, the occurrence of gastric c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/473A61K36/62A61P1/04A61P35/00A23L33/105
CPCA61K31/473A61K36/62A61P1/04A61P35/00A23L33/105A23V2002/00A61K2300/00A23V2200/32A23V2200/308A23V2250/21A61K36/48A23L33/40
Inventor 李梢
Owner TSINGHUA UNIV
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