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Composition for activating fatty acid-G protein coupling acceptor route

A technology for coupling receptors and compositions, applied in the field of medicine, can solve problems such as limited drug effects, and achieve the effects of increasing abundance, maintaining host intestinal health, and reducing expression levels

Inactive Publication Date: 2019-10-15
MACAU UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, although CN102743420A discloses the method and application of improving the structure of intestinal flora, it does not clearly reveal how the structure of intestinal flora affects intestinal health, and the drug effect provided to improve the structure of intestinal flora limited

Method used

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  • Composition for activating fatty acid-G protein coupling acceptor route
  • Composition for activating fatty acid-G protein coupling acceptor route
  • Composition for activating fatty acid-G protein coupling acceptor route

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 (the polysaccharide in the composition is from the extract of Ganoderma lucidum, and the composition does not contain saponin)

[0054] A composition for activating fatty acid-G protein coupled receptor pathway, comprising polysaccharide; the polysaccharide is derived from the extract of medicinal material A, and the medicinal material A is Ganoderma lucidum.

[0055] In the composition, by weight percentage, the content of polysaccharide is 20%.

[0056] The content of the polysaccharide in the extract of medicinal material A is 50% by weight.

[0057] The extract of the medicinal material A also contains protein and alkaloids. The alkaloids are water-soluble alkaloids.

[0058] In the extract of the medicinal material A, by weight percentage, the protein content is 15%, and the alkaloid content is 1%.

[0059] The preparation process of the extract of the medicinal material A is as follows:

[0060] (1) Take medicinal material A, then pulverize, add 9 ti...

Embodiment 2

[0066] Embodiment 2 (the saponin in the composition comes from the extract of Gynostemma pentaphyllum, does not contain polysaccharide in the composition)

[0067] A composition for activating fatty acid-G protein-coupled receptor pathway, comprising saponin; the saponin is derived from the extract of medicinal material B, and the medicinal material B is Gynostemma pentaphyllum.

[0068] In the composition, by weight percentage, the content of saponin is 50%.

[0069] The content of said saponin in the extract of medicinal material B is 70% by weight.

[0070] In the extract of the medicinal material B, by weight percentage, the content of flavonoids is 3%, and the content of amino acids is 2%.

[0071] The preparation process of the extract of the medicinal material B is as follows:

[0072] (1) Take medicinal material B, then pulverize, add 10 times the weight of water or alcohol (that is, the quality of water or alcohol is 10 times the mass of medicinal material B), decoc...

Embodiment 3

[0080] A composition for activating fatty acid-G protein-coupled receptor pathway, comprising polysaccharide and saponin; the polysaccharide is derived from the extract of medicinal material A, and the medicinal material A is Ganoderma lucidum.

[0081] The saponin is derived from the extract of medicinal material B, which is Gynostemma pentaphyllum.

[0082] In the composition, by weight percentage, the content of polysaccharide is 30%, and the content of saponin is 40%.

[0083] The content of the polysaccharide in the extract of medicinal material A is 70% by weight.

[0084] In the extract of the medicinal material A, by weight percentage, the protein content is 15%, and the alkaloid content is 0.5%.

[0085] The content of said saponin in the extract of medicinal material B is 50% by weight.

[0086] In the extract of the medicinal material B, by weight percentage, the content of flavonoids is 4%, and the content of amino acids is 2%.

[0087] The preparation process o...

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Abstract

The invention belongs to the field of medicines, and discloses a composition for activating a fatty acid-G protein coupling acceptor route. The composition contains polysaccharide and / or saponin, wherein the polysaccharide is from an extract of medicinal materials A, and the medicinal materials A are selected from one or more of glossy ganoderma, poria cocos, fungus umbellatus, antrodia cinnamomea, shiitake mushrooms, fungi, Chinese caterpillar fungi and cordyceps militaris; and the saponin is from an extract of medicinal materials B, and the medicinal materials B are selected from one or moreof ginseng and processed products thereof, pseudo-ginseng and fiveleaf gynostemma herbs. The composition disclosed by the invention can effectively increase the abundance of short chain fatty acid generation bacteria in a host body, and increase the contents of short chain fatty acid, protein G coupling acceptors, and activating acceptors and peptide tyrosine of downstream signaling molecule peroxisome proliferation agents. Besides, the expression level of histone deacetylase in intestinal tracts can be reduced, and further important guarantee is provided for maintaining health of the intestinal tracts of the host. In addition, the composition disclosed by the invention is high in safety.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a composition for activating fatty acid-G protein coupling receptor pathway. Background technique [0002] There is a close symbiotic relationship between the flora in the host intestine and the host. Studies in recent years have shown that the intestinal flora plays an important role in the host's immunity and metabolism. On the one hand, the intestinal flora can maintain the stability of the host's immune function by producing specific antigens. On the other hand, the intestinal flora can Metabolites of vitamin K, fatty acids (fatty acids include long-chain fatty acids (organic fatty acids with more than 12 carbon atoms), medium-chain fatty acids (organic fatty acids with 7-12 carbon atoms), and short-chain fatty acids (organic fatty acids with carbon atoms 2-6 organic fatty acids, specifically including acetic acid, propionic acid, isobutyric acid, butyric acid, isovaleric...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K31/715A61K36/076A61K36/07A61K36/068A61K36/424A61K36/258A61P1/00A23L31/00A23L33/105A23K10/30
CPCA23V2002/00A61K31/715A61K36/068A61K36/07A61K36/074A61K36/076A61K36/258A61K36/424A61K2236/331A61K2236/333A61K2236/51A61K2236/53A23K10/30A23L31/00A23L33/105A61P1/00A61K2300/00A23V2200/308A23V2200/32A23V2250/21A23V2250/208A23V2250/2124
Inventor 萧文鸾伊姆兰·可汗黄国鑫李晓盎夏文睿梁伟杰
Owner MACAU UNIV OF SCI & TECH
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