Pre-mixed antimicrobial, fast-curing, and collapse-resistant calcium silicate-based bioactive materials

A bioactive, fast curing technology, applied in the field of biomedical materials, can solve the problems of increasing extra treatment time, uneven physical and chemical properties, affecting the patient's medical experience, etc., to improve the efficacy of root canal treatment, shorten the curing time, and achieve excellent flow Effects of sexual and injectable properties

Active Publication Date: 2021-08-06
NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical use, dentists are required to adjust the liquid-solid two-phase immediately on site, which also brings the following problems: First, this method of temporarily adjusting the slurry brings inconvenience to the doctor’s operation and increases additional treatment time. Affect patient experience
Second, the deployment of liquid-solid two-phase in a relatively open system is likely to bring the risk of bacterial contamination of the paste slurry, resulting in reinfection of the tooth and triggering an inflammatory response, leading to the failure of root canal treatment
Third, the operation performance of MTA is poor, and it has a strong sandy feeling when mixed, which can easily lead to insufficient and uneven mixing, resulting in a decline in the physical and chemical properties of the slurry during the hydration and hardening process, thereby adversely affecting the tooth filling effect
However, so far there has been no report on the use of disodium hydrogen phosphate powder as an anti-collapse material to improve the anti-collapse performance of calcium silicate paste and apply it to dental filling materials

Method used

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  • Pre-mixed antimicrobial, fast-curing, and collapse-resistant calcium silicate-based bioactive materials
  • Pre-mixed antimicrobial, fast-curing, and collapse-resistant calcium silicate-based bioactive materials
  • Pre-mixed antimicrobial, fast-curing, and collapse-resistant calcium silicate-based bioactive materials

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] First weigh 1.8g of tricalcium silicate powder and 0.2g of disodium hydrogen phosphate, mix evenly, then select polyethylene glycol as the non-aqueous phase carrier, weigh 1.2g and mechanically stir with the above solid phase powder, A premixed paste is formed, which is then stored in a syringe.

[0042] Inject the prepared premixed paste into the simulated body fluid, and observe whether the pasty slurry collapses. The results are as follows: figure 1 As shown, the pasty slurry can maintain its original shape after soaking in the liquid phase for 30 minutes.

[0043] As a comparison, Example 1 is also used as a basic example in the present invention. Under other conditions being the same, under the condition of not adding disodium hydrogen phosphate, the prepared calcium silicate-based bioactive material is soaked in liquid phase respectively. Characterize the collapse performance after soaking the liquid phase for 30 minutes; figure 2 and image 3 Respectively, a ...

Embodiment 2

[0045] First weigh 2.16g of tricalcium silicate powder, 0.24g of disodium hydrogen phosphate and 0.6g of zirconia powder, mix them uniformly, then select polyethylene glycol as the non-aqueous phase carrier, weigh 1.8g and mix with the above solid The phase powder is mechanically stirred to form a premixed paste, and then the paste is put into a syringe for storage.

[0046] The X-ray opacity performance of the premixed paste was measured with an X-ray machine, and the results are shown in Table 1. The premixed paste has a radiopaque performance equivalent to a thickness of 3.04mm aluminum plate, which is higher than the clinical requirement of 3mm for dental filling materials. The anti-radiation performance of the thickness of the aluminum plate has sufficient X-ray anti-radiation performance, which can meet the requirements of clinical applications. After preliminarily curing the above-mentioned premixed slurry, the tooth body was soaked in simulated body fluid for 7 days, a...

Embodiment 3

[0050] First weigh 1.2g of tricalcium silicate powder and 0.8g of disodium hydrogen phosphate, mix evenly, then select polyethylene glycol as the non-aqueous phase carrier, weigh 1.2g and mechanically stir with the above solid phase powder, A premixed paste was formed, poured into molds and cured at 37°C.

[0051]The curing time of the premixed paste was measured by a penetrometer. The results are shown in Table 2. Compared with the premixed slurry without disodium hydrogen phosphate, the curing time of the composite slurry was reduced from 10.95 hours to 3.7 hours. Hours, the results show that the addition of disodium hydrogen phosphate can significantly reduce the curing time of the premixed paste, which is beneficial to promote the hydration reaction of calcium silicate-based gelling materials.

[0052] Table 2 curing time test results

[0053]

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Abstract

The invention discloses a premixed antibacterial, fast curing, and anti-collapse calcium silicate-based bioactive material, which belongs to the field of biomedical materials. The invention uses calcium silicate compound as the main phase, and adds disodium hydrogen phosphate powder and X Radiation blocking agent, and a pre-mixed anti-collapse bioactive material is prepared with a non-aqueous phase that can be miscible with water as a liquid carrier; the material of the present invention does not need to be reconciled on site, can be used at any time, and is easy to operate. Hydration occurs and hardens upon contact with aqueous physiological fluids. The invention applies the disodium hydrogen phosphate fast-setting anti-collapse agent to the premixed calcium silicate-based bioactive material, which not only significantly improves the anti-collapse performance of the material in the water phase environment, but also has a shorter curing time , superior biological activity, antibacterial properties, radio-blocking properties and sealing properties, simple preparation and convenient clinical use, etc.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a premixed antibacterial, fast-curing, and anti-collapse calcium silicate-based bioactive material and a preparation method thereof. Background technique [0002] Teeth are the hardest and highly calcified tissues in the human body. When teeth are subjected to long-term effects of bacteria, mechanical or chemical factors, pulp disease and periapical disease are often induced. Root canal therapy is currently one of the most effective methods for treating periapical diseases such as pulp, and has the best long-term curative effect. Root canal therapy usually includes three basic steps: root canal preparation, root canal disinfection, and root canal filling. The quality of root canal filling is one of the key factors for root canal treatment efficacy. When root canal filling is not strict, the Interstitial fluid will seep into the root canal and provide nutrients for the microor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K6/838A61K6/76A61K6/70A61K6/15
CPCA61K6/54A61K6/15A61K6/70A61K6/851A61K6/838
Inventor 汪涛吴蒙聂云鹏张悦查伟
Owner NANJING UNIV OF AERONAUTICS & ASTRONAUTICS
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