Three-dimensional (3D) printing tubular porous titanium alloy prosthesis for limb large-segment bone defect and preparation method of 3D printing tubular porous titanium alloy prosthesis

Abstract

The invention relates to three-dimensional (3D) printing tubular porous titanium alloy prosthesis for limb large-segment bone defects and a preparation method of the 3D printing tubular porous titanium alloy prosthesis. The preparation method comprises the following steps: designing hollow tubular porous titanium alloy prosthesis with a bone fracture plate according to thin-layer computed tomography (CT) scanning data of a patient in combination with an operation path and an osteotomy plane shape of a lesion part, and introducing the prosthesis design data into metal 3D printing equipment to prepare a tubular porous titanium alloy prosthesis; placing the prepared tubular porous titanium alloy prosthesis in an electrolyte of calcium acetate and beta sodium glycerophosphate to carry out micro-arc oxidation treatment on the tubular porous titanium alloy prosthesis, and then treating the tubular porous titanium alloy prosthesis in a constant-temperature water bath to obtain a 3D printing tubular titanium alloy prosthesis with titanium oxide on the surface; placing the 3D printing tubular titanium alloy prosthesis with titanium oxide on the surface in a Ba (OH) 2 solution and adjustingthe pH to 13 to react to form barium titanate on the surface of the 3D printed tubular titanium alloy prosthesis of titanium oxide. By the surface active treatment, the biocompatibility of the prosthesis is improved, new bone growth is induced, and a good bone integration effect is achieved; and the integrated bone fracture plate is high in fit degree with a backbone, and fixation reliability is improved. No additional auxiliary internal fixation is required.

Description

technical field [0001] The invention relates to a tubular porous titanium alloy prosthesis, in particular to a 3D printed tubular porous titanium alloy prosthesis for large segmental bone defects in limbs and a preparation method thereof. Background technique [0002] The repair of large bone defects caused by trauma, tumor, infection, etc. is a common and difficult problem in clinical practice. Allograft bone and autologous vascularized fibula are currently the most commonly used methods for repairing long bone defects. The advantage of allograft bone is that it can provide bone mass and early support, but it takes a long time to activate, has a low healing rate with the recipient, and is prone to infection. The advantages of autologous vascularized bone are living bone transplantation, high healing rate, and certain anti-infection ability. However, due to the small diameter of the vessel, it is not suitable to be used alone for bone defects of lower limbs, and the inciden...

AI Technical Summary

Problems solved by technology

The advantage of allograft bone is that it can provide bone mass and early support, but it takes a long time to activate, has a low healing rate with the recipient, and is prone to infection

The advantages of autologous vascularized bone are living bone transplantation, high healing rate, and certain anti-infection ability. However, due to the small diameter of the vessel, it is not suitable to be used alone for bone defects of lower limbs, and the incidence of secondary fractures during the remodeling process after fibula healing is high.

[0003] Although the currently clinically used titanium alloy (Ti-6Al-4V) has good mechanical strength, it still has obvious defects in the clinical application process: 1. The elastic modulus (110GPa) is much higher than that of normal bone (cortical bone). About 15GPa), resulting in stress shielding, resulting in bone resorption and poor bone-metal interface integration; 2. Titanium alloy is a biologically inert material, which does not have a good stimulating effect on bone formation around the material, resulting in the amount and speed of bone ingrowth slower

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