Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Glucosamine hydrochloride bone joint intelligent hydrogel, preparation method and use thereof

A technology of glucosamine hydrochloride and hydrogel, which is applied in the field of intelligent hydrogel, can solve the problems of prolonging the release time of glucosamine hydrochloride, and that glucosamine hydrochloride has no topical dosage form, so as to achieve a suitable gel phase transition temperature and reduce the temperature of the whole body. Toxic and side effects, reducing irritation effect

Active Publication Date: 2019-09-03
SICHUAN AGRI UNIV
View PDF5 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to provide a glucosamine hydrochloride bone joint intelligent hydrogel and its preparation method and application. The intelligent hydrogel solves the problem that the existing glucosamine hydrochloride has no local dosage form, and can be administered locally through the joint cavity Drugs to effectively target glucosamine hydrochloride to articular cartilage and prolong the release time of glucosamine hydrochloride in the body

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glucosamine hydrochloride bone joint intelligent hydrogel, preparation method and use thereof
  • Glucosamine hydrochloride bone joint intelligent hydrogel, preparation method and use thereof
  • Glucosamine hydrochloride bone joint intelligent hydrogel, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0030] Experimental example 1 Preparation of glucosamine hydrochloride bone joint intelligent hydrogel

[0031] Accurately weigh an appropriate amount of P407 (Poloxamer 407, Poloxamer 407) and P188 (Poloxamer 188, Poloxamer 188) into a beaker, add a certain amount of water for injection, and then put it in a refrigerator at 4°C for 24 hours. P407 and P188 are completely swollen Finally, a clear, transparent and flowable polymer solution is obtained, which is a blank smart hydrogel.

[0032] Add different amounts of glucosamine hydrochloride (GlcN·HCl), NaHSO 3 , NaHCO 3 , and stirred until completely dissolved and uniform, placed in a 4°C refrigerator to obtain a clear and transparent solution, and obtained glucosamine hydrochloride bone joint smart hydrogel with different component contents. Among them, NaHSO 3 Improve the stability of glucosamine hydrochloride in aqueous solution, NaHCO 3 As a pH regulator.

[0033] In the present invention, the adjuvant that can be us...

experiment example 2

[0034] The influence of experimental example 2 glucosamine hydrochloride, P407 and P188 content on the gelling temperature of the present invention

[0035] Test tube inversion method: take 3mL of gel and put it in a 15mL test tube. The temperature of the water bath is raised slowly by 1°C each time. Invert the test tube, when the gel changes from a flowing liquid to a non-flowing semi-solid, it is gelled, and record the temperature at this time. Three groups were measured in parallel, and the average value was taken as the gelling temperature of the gel.

[0036] (1) Effect of P407 content on gelation temperature

[0037]Accurately weigh an appropriate amount of P407 and place it in 20 mL of water, place it at 4°C to obtain P407 solutions with mass fractions (w / v) of 18%, 20%, 22%, 24%, 26%, 28% and 30%, respectively, The gelation temperature was measured by the above test tube inversion method.

[0038] As shown in Table 1 below, it is the influence of the P407 content on...

experiment example 3

[0054] Experimental example 3 gelation characteristics and release of smart hydrogel

[0055] (1) Gelling properties

[0056] Using the method of Experimental Example 1 to prepare the glucosamine hydrochloride bone joint intelligent water gel of the present invention, its composition is: 23% P407 + 6% P188 + 5% glucosamine hydrochloride + 0.2% NaHSO 3 , NaHCO 3 Adjust pH=6.

[0057] The glucosamine hydrochloride bone joint smart hydrogel prepared above is in the state of a colorless, transparent and flowable viscous liquid at room temperature, and it is a colorless, transparent and flowable semi-solid when placed at physiological temperature (37°C) for 5-10 minutes gel state.

[0058] (2) In vitro release of smart hydrogels

[0059] The membrane release method was used to measure the release in vitro, as follows:

[0060] Put the glucosamine hydrochloride bone joint smart hydrogel prepared in this experimental example into a dialysis bag with a molecular cut-off of 8000-1...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a glucosamine hydrochloride bone joint intelligent hydrogel, a preparation method and use thereof. The intelligent hydrogel comprises: P407, P188, water, NaHSO3, NaHCO3 and glucosamine hydrochloride; wherein the mass fraction of the P407 is 20% to 24%, and the mass fraction of the P188 is 2% to 8%; the mass fraction of NaHSO3 is 1% to 2%; and the mass fraction of glucosamine hydrochloride is 3% to 8%; and the pH of the NaHCO3 is adjusted to 5-7. The intelligent hydrogel of the invention is locally administered through the joint cavity, so that the glucosamine is effectively targeted to the articular cartilage, the gelation transformation is achieved under the action of body temperature, the release time of glucosamine in the body is prolonged, the injection stimulation of a drug is reduced to reduce the irritation to the body, and the therapeutic effect on osteoarthritis can be achieved.

Description

technical field [0001] The invention relates to an intelligent hydrogel, in particular to a glucosamine hydrochloride bone joint intelligent hydrogel and its preparation method and application. Background technique [0002] Osteoarthritis (OA) is a general term for bone and joint diseases. It is a chronic and progressive disease caused by trauma, congenital abnormalities of joints, joint deformities, cartilage rupture or destruction, etc. It is also a common disease in pet dogs. a joint disease. The pathogenesis of osteoarthritis is not yet clear, and many factors can induce its occurrence, so the treatment methods are also different. [0003] The principle of osteoarthritis treatment is to relieve pain, control inflammation and promote cartilage healing, generally including physical therapy (exercise, weight loss, massage, etc.), drug therapy, surgical treatment, nutritional therapy, etc. In drug treatment, doctors often use anti-inflammatory drugs to achieve anti-inflamm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/06A61K47/10A61K31/7008A61P19/08A61P19/02
CPCA61K9/06A61K9/0024A61K47/10A61K31/7008A61P19/08A61P19/02
Inventor 符华林张廷婷李东波杨文竹张伟舒刚袁志翔彭广能钟志军
Owner SICHUAN AGRI UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com