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A kind of preparation method of patulin magnetic molecularly imprinted polymer

A magnetic molecular imprinting, patulin technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of limited effective detection, unsatisfactory purification effect, co-extraction matrix effect of impurities, etc., and achieve efficient separation and enrichment. Effect

Active Publication Date: 2021-11-30
BEIJING PURKINJE GENERAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to cumbersome pretreatment and large matrix interference, the effective detection of patulin residues in complex samples by conventional rapid detection methods and instrumental analysis methods is severely limited.
In addition, traditional pretreatment methods such as QuEChERS and solid-phase extraction have poor selectivity, unsatisfactory purification effect, and impurity co-extraction matrix effect often occurs, which affects the later instrument analysis results. It is necessary to have a strong pre-processing technology
At present, most of the molecularly imprinted polymer preparation methods for patulin adopt traditional bulk polymerization and precipitation polymerization methods, and sample separation and extraction still require cumbersome processes such as centrifugation, column passing, and nitrogen blowing.

Method used

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  • A kind of preparation method of patulin magnetic molecularly imprinted polymer
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  • A kind of preparation method of patulin magnetic molecularly imprinted polymer

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Preparation of Fe3O4 nanoparticles: Co-precipitation method was used to prepare Fe3O4 magnetic nanoparticles. Weigh 2.12g FeCl3·6H2O and 0.5g FeCl2·4H2O and ultrasonically disperse them in 5mL ultrapure water respectively. Transfer the above two solutions to a three-necked bottle, and add a certain amount of water to the bottle. Put it into an electric constant temperature water bath and stir the reaction. When the temperature rises to 70°C, add 6mL of 25% ammonia water, then raise the temperature to 80°C, stir for 10min, add 0.05g of sodium citrate, and stir for 10min. Cool to room temperature after the reaction is over, separate Fe3O4 with a magnet, wash with ethanol until it is neutral, and dissolve the obtained Fe3O4 solid in ethanol for preservation.

[0027] (2) Preparation of Fe3O4@SiO2 particles

[0028] Take the Fe3O4 magnetic nanoparticles prepared in the above steps into a 250mL three-necked flask, add 12mL of pure water and 48mL of ethanol, and disperse ul...

example 2

[0034](1) Preparation of Fe3O4 nanoparticles: Co-precipitation method was used to prepare Fe3O4 magnetic nanoparticles. Weigh 2.3g FeCl3·6H2O and 0.9g FeCl2·4H2O, respectively, and ultrasonically disperse them in 5mL ultrapure water. Transfer the above two solutions to a three-necked bottle, and add a certain amount of water to the bottle. Put it in an electric constant temperature water bath and stir for reaction. When the temperature rises to 70°C, add 10mL of 25% ammonia water, then raise the temperature to 80°C, stir for 40min, add 0.1g of sodium citrate, and stir for 20min. Cool to room temperature after the reaction is over, separate Fe3O4 with a magnet, wash with ethanol until it is neutral, and dissolve the obtained Fe3O4 solid in ethanol for preservation.

[0035] (2) Preparation of Fe3O4@SiO2 particles

[0036] Take the Fe3O4 magnetic nanoparticles prepared in the above steps into a 250mL three-necked flask, add 20mL pure water and 80mL ethanol, and disperse by ult...

example 3

[0042] (1) Preparation of Fe3O4 nanoparticles: Co-precipitation method was used to prepare Fe3O4 magnetic nanoparticles. Weigh 2.8g FeCl3·6H2O and 1.0g FeCl2·4H2O, respectively, and ultrasonically disperse them in 5mL ultrapure water. Transfer the above two solutions to a three-necked bottle, and add a certain amount of water to the bottle. Put it into an electric constant temperature water bath and stir for reaction. When the temperature rises to 70°C, add 15mL of 25% ammonia water, then raise the temperature to 80°C, stir for 40min, add 0.2g of sodium citrate, and stir for 20min. Cool to room temperature after the reaction is over, separate Fe3O4 with a magnet, wash with ethanol until it is neutral, and dissolve the obtained Fe3O4 solid in ethanol for preservation.

[0043] (2) Preparation of Fe3O4@SiO2 particles

[0044] Take the Fe3O4 magnetic nanoparticles prepared in the above steps into a 250mL three-neck flask, add 20mL pure water and 70mL ethanol, and ultrasonically...

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Abstract

The invention discloses a patulin magnetic molecularly imprinted polymer, which can realize the application of specific recognition, efficient separation and enrichment of patulin in agricultural products through magnetic separation technology and molecular imprinting recognition technology, and has good adsorption And separation performance, can achieve the specific adsorption of patulin.

Description

technical field [0001] The invention relates to the field of patulin extraction and detection methods, in particular to a preparation method of a patulin magnetic molecular imprinted polymer. Background technique [0002] Molecularly imprinted polymers (MIPs) are a new type of polymer biomimetic material with strong molecular recognition ability. It has the characteristics of specificity, bookability, low preparation cost and reusability. Extractive sorbents are used for complex sample preparation. Patulin is a toxic metabolite produced by patulin, penicillium expanses, and aspergillus patulin. Patulin is widely found in various mildewed fruits, and patulin is a small molecular compound, easily soluble in water, high in thermal stability, relatively stable in acidic solution, and it is difficult to remove it by general heating, drying and other methods . Therefore, if moldy fruit is used to process fruit juice, the possible presence of patulin in the fruit juice will affe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F292/00C08F226/06C08F222/14C08J9/26B01J20/26B01J20/30
CPCB01J20/268C08F292/00C08J9/26C08J2201/0424C08J2351/10C08F222/103
Inventor 佘永新邵华赵民娟王淼何亚荟郑鹭飞金芬王静
Owner BEIJING PURKINJE GENERAL INSTR
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