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Joint synovial fluid preparation method for reducing wear of titanium alloy artificial joint materials

A technology for artificial joints and synovial fluid, which is used in pharmaceutical formulations, surgery, and drug delivery. Good performance and safety, and the effect of reducing wear and tear

Active Publication Date: 2021-09-21
HEFEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Studies have shown that the anti-friction and anti-wear performance of ceramic artificial joint materials can be enhanced by adding good biocompatible lubricating particles to the synovial fluid, and the life of the joint material can be prolonged. However, the dispersion of lubricating particles in the synovial fluid has always been There is no good solution. In addition, there are few reports on improving the titanium alloy joint material by adding lubricating particles. As the main material of the artificial joint friction pair, the wear resistance of titanium alloy needs to be further improved. In addition, due to the friction pair material The existing methods for improving the anti-wear effect of artificial joints are not transferable

Method used

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  • Joint synovial fluid preparation method for reducing wear of titanium alloy artificial joint materials

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Embodiment Construction

[0014] The present invention is described in detail below in conjunction with specific embodiment:

[0015] Put 0.8g of N-isopropylacrylamide, 15mg of N,N'-methylenebisacrylamide, and 10mg of sodium dodecylsulfonate into a beaker containing 60mL of deionized water, and stir magnetically for 20 minutes to obtain a mixed solution. Then the mixed solution was added to the three-necked flask, and after the flask was sealed and evacuated, high-purity nitrogen gas was introduced until the pressure in the flask returned to 1 atm, and then 5 mL of 0.008 g / mL ammonium persulfate solution was added to the flask through a syringe. The reaction was carried out at 70° C. for 5 hours, and the prepared sample was dialyzed for 10 days, deionized water was replaced every 12 hours, and prepared into a 1.35 wt % poly-N-isopropylacrylamide solution for use. Next, 4 mL of 0.5 mol / L sodium azide solution was added to 20 mL of calf serum, and then 0.2 mol / L sodium phosphate was added to control the ...

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Abstract

The invention discloses a method for preparing joint synovial fluid for reducing wear of titanium alloy artificial joint materials. The method comprises the preparation of nano lubricating particle poly-N-isopropylacrylamide and its dispersion in joint synovial fluid. The method of the invention is simple and effective, can improve the lubricating performance of artificial joint synovial fluid, significantly reduce the wear of titanium alloy artificial joint materials, and has great application potential in the fields of artificial joints, biomedicine, intelligent materials and the like.

Description

technical field [0001] The invention relates to the field of artificial joint lubrication, in particular to a method for preparing joint synovial fluid which reduces wear of titanium alloy artificial joint materials by adding a lubricant. Background technique [0002] There are more than 36 million people with joint diseases in our country, of which about 2 million people need joint replacement surgery every year, and this number is still rising. Patients undergoing joint replacement surgery often have aseptic loosening problems due to the friction and wear of artificial joint materials. In addition, the abrasive particles brought by the wear will also cause inflammation in the joints, which will bring pain to the patient in severe cases, and even To completely incapacitate the patient, it is therefore crucial to reduce the wear and tear of the artificial joint material. [0003] At present, the most common way to solve the problem of aseptic loosening and abrasive particle...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/04A61L31/14
CPCA61L31/048A61L31/14A61L2400/10C08L33/26
Inventor 徐玉福胡苑华田明刘志超彭玉斌姚路路
Owner HEFEI UNIV OF TECH
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