Compound based on flos lonicerae-radix glycyrrhizae medicine pair and application of compound

A honeysuckle and compound technology, applied in the compound field, can solve the problems of high treatment cost, slow onset, high price and the like, and achieve the effects of improving taking safety, improving drug efficacy and taking convenience.

Pending Publication Date: 2019-08-23
JIANGYIN TIANJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, surgical treatment has a good curative effect on patients with early chronic pharynx, but the treatment is expensive and difficult to be accepted by consumers
There are many drugs for treating chronic pharyngitis on the market today, but they are expensive and the treatment effect is not good. Once the dosage is too large, it will not only lead to drug resistance in patients, but may even cause side effects and adverse reactions
TCM syndrome differentiation and treatment is a method with many reports on existing invention patents, but most of the raw materials used are those that cannot be used in ordinary foods, and there are few discussions on the safety of prescriptions
In addition to the above technical problems, people now often buy their own medicinal materials and take them after decoction and brewing. This way of taking not only lacks the quality control of raw materials, but also cannot guarantee the full dissolution of active ingredients, and the effect is slow. Different medicinal materials or decoction pieces The ratio between them cannot be precisely controlled, and the efficacy cannot be guaranteed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064]Example 1: Preparation method of honeysuckle-licorice root clathrate to volatile oil

[0065] Prescription: Honeysuckle 10kg, Licorice 10kg

[0066] The preparation method of the throat clearing composition of the present embodiment comprises the following steps:

[0067] 1) Processing: remove impurities from licorice, wash, moisten thoroughly, cut into thick slices, and dry.

[0068] 2) Preparation of honeysuckle-licorice volatile oil clathrate: Take the formula amount of honeysuckle and licorice and mix according to the ratio of 1:1, put it into the extraction tank and slowly feed the steam, collect the distillate after preliminary oil-water separation for 1 hour; the cooling water inlet temperature ≤35°C, cooling water outlet temperature ≤60°C, volatile oil extraction temperature 90-100°C. Separate the volatile oil. According to the ratio of volatile oil to β-cyclodextrin is 1:10, take β-cyclodextrin and put it in a colloid mill, add appropriate amount of water, sl...

Embodiment 2

[0069] Example 2: A compound for clearing the throat and nourishing the stomach and its preparation

[0070] Prescription: 5kg of honeysuckle, 5kg of licorice, 5kg of tangerine peel, 4kg of bellflower, and 4kg of green fruit.

[0071] The preparation method of the throat clearing composition of the present embodiment comprises the following steps:

[0072] 1) Processing: Remove impurities from platycodon root, wash, moisten thoroughly, cut into thick slices, and dry; remove impurities from licorice, wash, moisten thoroughly, cut into thick slices, and dry; remove impurities from tangerine peel, spray with water, moisten thoroughly, shred, Drying; remove impurities from the green fruit, wash, dry, and crush when used.

[0073] 2) Preparation of honeysuckle-licorice volatile oil clathrate: Component A was obtained according to the preparation method of Example 1 with 20% honeysuckle and licorice.

[0074] 3) Extraction: By decocting in water, take the remaining honeysuckle, li...

Embodiment 3

[0090] Example 3: A compound for clearing away heat and detoxification, promoting lung and relieving throat and its preparation

[0091] Prescription: 5kg honeysuckle, 5kg licorice, 4kg bellflower, 4kg green fruit, 3kg Luo Han Guo, 2kg fat sea.

[0092] The preparation method of the throat clearing composition of the present embodiment comprises the following steps:

[0093] 1) Processing: Remove impurities from bellflower, wash, moisten thoroughly, cut into thick slices, and dry; remove impurities from licorice, wash, moisten, cut into thick slices, and dry; remove impurities from fat sea, coarsely crush; remove impurities from green fruits, wash , dry, broken when used.

[0094] 2) Preparation of honeysuckle-licorice volatile oil clathrate: honeysuckle and licorice with a formulation amount of 20% were prepared according to Example 1.

[0095] 3) Extraction: By decocting in water, take the remaining honeysuckle, licorice, processed bellflower and green fruit according to t...

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PUM

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Abstract

The invention relates to a compound based on a flos lonicerae-radix glycyrrhizae medicine pair. The compound comprises a composition A and a composition B, wherein the composition A comprises a volatile oil clathrate of flos lonicerae and radix glycyrrhizae, and the composition B mainly comprises flos lonicerae, radix glycyrrhizae and a water extract selected from one or more of platycodon grandiflorum, dried orange peels, fructus canarli, semen sterculiae lychnophorae and fructus momordicae. A formula of the composition B can be specifically selected according to the cause of pharyngitis; forexample, when the formula of the composition B which includes flos lonicerae, radix glycyrrhizae, platycodon grandiflorum, fructus canarli, semen sterculiae lychnophorae and fructus momordicae is designed, the composition B can be suitable for patients with chronic pharyngitis caused by lung discomfort and has the effects of clearing the throat and moistening the lung. The compound eliminates thesymptoms of chronic pharyngitis from an antibacterial and anti-inflammatory aspect and adopts the flos lonicerae-radix glycyrrhizae medicine pair as the basic medicinal material, remaining flos lonicerae and radix glycyrrhizae are mixed with other medicinal materials for water extraction, and the antibacterial and anti-inflammatory efficacy of the volatile oil clathrate of flos lonicerae and radix glycyrrhiza and the water extract is fully utilized; the compound can be used for eliminating the cause of chronic pharyngitis through compatibility with other medicinal materials and has the effectof treating both symptoms and root causes.

Description

technical field [0001] The invention relates to a compound based on a honeysuckle-licorice medicine pair, in particular to a compound which is safer to take and more effective, as well as its preparation and application. Background technique [0002] With the rapid development of science and technology in contemporary society, the environment has been damaged to a certain extent. Along with air pollution, smoking or passive smoking in public places, and self-damage, a series of respiratory and lung diseases are caused. Common symptoms include sore throat, itching, swelling when swallowing, foreign body sensation and coughing. According to clinical reports, 10% to 20% of pharyngitis among urban residents in my country is chronic pharyngitis, accounting for 12% to 14% of ENT diseases. Chronic pharyngitis can occur in children less than 10 years old and the elderly over 74 years old. When symptoms such as cough or morning nausea and retching interfere with the patient for a ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K36/484A61K36/73A61K47/69A61P11/04A61K35/644
CPCA61K35/644A61K36/185A61K36/32A61K36/346A61K36/355A61K36/42A61K36/484A61K36/73A61K36/752A61K2236/331A61K47/6951A61P11/04A61K2300/00
Inventor 吴名草陆倩倩孙培娜潘婷周敏黄晓瑜
Owner JIANGYIN TIANJIANG PHARMA
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