A kind of medicine for treating mammary gland hyperplasia containing flat lying chrysanthemum notoginseng and its preparation method and application

A technology for supine chrysanthemum notoginseng and mammary gland hyperplasia, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, drug combinations, etc. It can solve problems such as deterioration, repeated disease, and inappropriate long-term use by patients, and maintain tissue shape , low price, and the effect of reducing the number of lobular hyperplasia and the number of obliterated glandular ducts

Active Publication Date: 2021-11-05
深圳市仁福生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on these cognitions, there have been Chinese patent medicines for the treatment of breast addiction in Chinese medicine, such as Xiaojin Wan, Rupixiao, Xiaoyao Granules, Rukang Tablets, etc.; , Bupleurum or Prunella vulgaris and other drugs that have obvious toxicity to liver damage are not suitable for patients to take for a long time, and the discontinuation of these drugs will easily lead to relapse and further deterioration of the disease

Method used

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  • A kind of medicine for treating mammary gland hyperplasia containing flat lying chrysanthemum notoginseng and its preparation method and application
  • A kind of medicine for treating mammary gland hyperplasia containing flat lying chrysanthemum notoginseng and its preparation method and application
  • A kind of medicine for treating mammary gland hyperplasia containing flat lying chrysanthemum notoginseng and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] The preparation method of embodiment 1 preparation 1, comprises the steps:

[0052] (1) Preparation of Ashitaba extract

[0053] Get 5kg of dry whole plant Ashitaba and pulverize it into powder that has passed through a 80-mesh sieve, put it into an extraction tank, add 25L of 80% (v / v) ethanol aqueous solution to it each time, and reflux extraction at 60°C for 2 times. Each time for 2 hours, the two extracts were combined, concentrated under reduced pressure, and freeze-dried to obtain 876.5 g of Ashitina extract powder, which was set aside.

[0054] (2) Preparation of malt extract

[0055] Take 3kg of dry malt (raw) and crush it into a powder that has passed through an 80-mesh sieve, put it into an extraction tank, add 15L of water to it each time, decoct twice at 60°C for 1.5 hours each time, and combine the two extractions solution, concentrated under reduced pressure, and freeze-dried to obtain 330.0 g of malt extract powder, which was set aside.

[0056] (3) Pr...

Embodiment 2

[0060] The preparation method of embodiment 2 preparation 2, comprises the steps:

[0061] (1) Preparation of Ashitaba extract

[0062] Get 5kg of dry whole plant Ashitaba and pulverize it into powder that has passed through a 80 mesh sieve, put it into an extraction tank, add 50L of 80% (v / v) ethanol aqueous solution to it each time, and reflux extraction at 80°C for 2 times, Each time for 1 hour, the two extracts were combined, concentrated under reduced pressure, and freeze-dried to obtain 1035.9 g of Ashitina extract powder, which was set aside.

[0063] (2) Preparation of malt extract

[0064] Take 3kg of dry malt (raw) and crush it into a powder that has passed through an 80-mesh sieve, put it into an extraction tank, add 30L of water to it each time, decoct twice at 80°C for 1 hour each time, and combine the two extractions solution, concentrated under reduced pressure, and freeze-dried to obtain 381.0 g of malt extract powder, which was set aside.

[0065] (3) Prepa...

Embodiment 3

[0068] The therapeutic effect of embodiment 3 preparation 1 on rat mammary gland hyperplasia

[0069] Non-pregnant female SD rats (provided by the Hubei Provincial Center for Disease Control and Prevention), weighing 180 g. Drink water and eat freely, keep the room temperature at 25±1°C, and the light-dark cycle is 12 hours.

[0070] (1) Modeling and administration of mammary gland hyperplasia

[0071] During the experiment period, the pelleted feed was fed, and the experimental period was entered after one week of observational feeding. Female SD rats were randomly divided into 5 groups (5 in each group): blank control group, model group, low-dose group of preparation 1, high-dose group of preparation 1, and Rupixiao group (Rupixiao is a kind of Capsules made of antlers, dandelion, kelp, Panax notoginseng, red peony root, seaweed, leaking reed, woody incense, scrophulariae, motherwort, Caulis Spatholobus, trigeminus, forsythia, gonggongmu, and Smilax tuckahoe, etc., have th...

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Abstract

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a medicine for treating mammary gland hyperplasia (known as breast addiction in traditional Chinese medicine), a preparation method and application thereof. The medicine is prepared from Ashitaba ethanol extract, malt water extract and hawthorn water extract. By comparing the treatment of model rats suffering from mammary gland hyperplasia, the compound medicine of the present invention can effectively: 1. reduce the serum estradiol content and increase the serum progesterone hormone level; The number of hyperplasia; ③ reduce the number of obliterated acini in the lobules of breast tissue; it has a good effect of soothing the liver and eliminating breast addiction.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a medicine for treating mammary gland hyperplasia and its preparation method and application. Background technique [0002] Mammary gland hyperplasia is the most common breast disease, which can occur in women of any age after the onset of puberty, and is most common in women aged 30-premenopause. Its incidence rate is as high as 60%, accounting for the first place in breast diseases. Mammary gland hyperplasia is a benign lesion of the mammary gland, which refers to the disorder of the normal structure of the mammary gland caused by the physiological hyperplasia and incomplete involution of the mammary gland lobules during the mature period or periodic changes. It is neither inflammation nor tumor. Obvious breast lumps and severe pain appear due to cycle and mood changes, and the course of the disease is long, slow, and easy to relapse, which se...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8998A61P15/14
CPCA61K36/232A61K36/734A61K36/8998A61P15/14A61K2300/00
Inventor 李玉桑黄夏伶蒙莎莎宋佳唐和斌
Owner 深圳市仁福生物科技有限公司
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