Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A detection method for accelerator m and accelerator dpg in Chinese patent medicine and health food

A technology of health food and detection method, which is applied in the fields of mass spectrometry and drug chromatography, and can solve the problems of no screening and quantitative methods

Active Publication Date: 2021-12-07
苏州市药品检验检测研究中心
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There have been no reports of the addition of accelerator M and accelerator DPG, and there are no screening and quantitative methods for these two substances. In the long-term health food illegal addition test, our laboratory found that accelerator M alone or simultaneously with sildenafil Added to the product, the accelerator DPG was added to the product alone (see Table 1)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A detection method for accelerator m and accelerator dpg in Chinese patent medicine and health food
  • A detection method for accelerator m and accelerator dpg in Chinese patent medicine and health food
  • A detection method for accelerator m and accelerator dpg in Chinese patent medicine and health food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] A detection method for accelerator M in Chinese patent medicine and health food, comprising the following steps:

[0104] (1) Chromatographic conditions:

[0105] Chromatographic column: ACQUITY UPLC®HSS T3, 100mm×2.1mm, 1.8μm; detector: diode array detector; detection wavelength: 210nm; scanning wavelength range 190-400nm; mobile phase: A-0.1% formic acid solution, B-0.1 % formic acid-acetonitrile; flow rate: 0.3mL / min; column temperature: 30℃; injection volume: 1μL; elution gradient program: 0-2min, 10%B; 7-9min, 90%B; %B;

[0106] Mass Spectrometry Conditions:

[0107] Electrospray positive ion mode; Capillary voltage: 3500V; Drying gas flow rate: 10.0L / min; Atomizing gas pressure: 40psig; Drying gas temperature: 350°C; Fragmentation voltage: 135V; Mass spectrometry; acquisition mode: target MS; precursor ion: 167.9934, retention time: 4.74min (chromatogram), 4.85min (mass spectrogram); collision energy: 25V, 35V; mass spectrometry scanning range: 50-1700;

[010...

Embodiment 2

[0117] A detection method of accelerator DPG in Chinese patent medicine and health food, comprising the following steps:

[0118] (1) Chromatographic conditions:

[0119] Chromatographic column: ACQUITY UPLC®HSS T3, 100mm×2.1mm, 1.8μm; detector: diode array detector; detection wavelength: 205nm; scanning wavelength range 190-400nm; mobile phase: A-0.1% formic acid solution, B-0.1 % formic acid-acetonitrile; flow rate: 0.3mL / min; column temperature: 30℃; injection volume: 1μL; elution gradient program: 0-2min, 10%B; 7-9min, 90%B; %B;

[0120] Mass Spectrometry Conditions:

[0121] Electrospray positive ion mode; Capillary voltage: 3500V; Drying gas flow rate: 10.0L / min; Atomizing gas pressure: 40psig; Drying gas temperature: 350°C; Fragmentation voltage: 135V; Mass spectrometry; acquisition mode: target MS; precursor ion: 212.1197, retention time: 2.88min (chromatogram), 2.99min (mass spectrogram); collision energy: 15V, 30V; mass spectrometry scanning range: 50-1700;

[01...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a method for detecting accelerator M and accelerator DPG in Chinese patent medicines and health foods, using ultra-high performance liquid chromatography-ultraviolet spectroscopy-time-of-flight mass spectrometry for qualitative screening and content determination. Chromatographic conditions: chromatographic column: C18 chromatographic column; detector: diode array detector; detection wavelength: accelerator M: 210nm; accelerator DPG: 205nm; scanning wavelength range: 190-400nm; mobile phase: A-0.1% formic acid solution , B-0.1% formic acid-acetonitrile; flow rate: 0.3-0.4 mL / min; column temperature: 25-40°C; injection volume: 0.1-2μL. The method of the present invention can be exclusive, sensitive and fast for initial screening, confirmation and quantification of accelerator M and accelerator DPG added in anti-fatigue Chinese patent medicines and health foods, and is mainly applicable to accelerator M and accelerators in tablet and capsule dosage forms Analysis of DPGs.

Description

technical field [0001] The invention belongs to the field of pharmaceutical chromatography and mass spectrometry analysis, relates to a detection method of chemicals, in particular to a detection method of accelerator M and accelerator DPG in Chinese patent medicine and health food. Background technique [0002] Accelerator M (2-mercaptobenzothiazole, CAS number: 149-30-4, molecular formula: C 7 h 5 NS 2 , Molecular weight: 167.0) is an accelerator for natural rubber and synthetic rubber in the industry. It can be used alone or in combination with sulfurized carbamates, thiurams, guanidines, and other alkaline accelerators. It has a rapid acceleration effect on natural rubber and general sulfur-sulfurized synthetic rubber. The critical temperature of sulfuration is low, and it is easy to disperse in rubber and does not pollute. Mainly used in the manufacture of tires, tapes, rubber shoes and other industrial rubber products. Exposure accelerator M may cause allergic skin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
CPCG01N30/02G01N2030/027
Inventor 贾昌平赵琪张珊珊张斌郑佳新郑梅陈丽波钱叶飞
Owner 苏州市药品检验检测研究中心
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com