Method for using amino acid analyzer to determine tranexamic acid content
A technology of tranexamic acid and amino acids, applied in the field of analysis, can solve problems such as low specificity, low sensitivity, and many influencing factors
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Embodiment 1
[0060] Embodiment 1, use amino acid analyzer to measure the tranexamic acid in the product
[0061] Test samples: drugs, tranexamic acid tablets, market sampling products, and the composition of excipients is unknown.
[0062] (1) Analytical instrument amino acid analyzer is provided, and what this embodiment uses is Biochrom30+ high-efficiency amino acid automatic analyzer; The chromogenic agent ninhydrin used for detection is produced by British Biochrom Ltd. (specifically used batch number: 20635);
[0063] (2) Provide the chromatographic column as the prewash column and the analysis column, all are ion exchange resin columns, the prewash column used in this embodiment has a length of 10cm and a diameter of 4.6mm and a particle size of 4 μm, and an analysis column has a length of 20cm and a diameter of 4.6mm and a particle size 8μm, the ion exchange resin of the chromatographic column is a special resin for Biochrom30+ high-efficiency amino acid automatic analyzer;
[0064...
Embodiment 2
[0078] Embodiment 2, use amino acid analyzer to measure the tranexamic acid in the product
[0079] Test samples: drugs, tranexamic acid powder injection for injection, market sampling products, the excipient is mannitol, and its weight ratio to the main drug is 1:5.
[0080] (1) Analytical instrument amino acid analyzer is provided, and what this embodiment uses is Biochrom30+ high-efficiency amino acid automatic analyzer; The chromogenic agent ninhydrin used for detection is produced by British Biochrom Ltd. (specifically used batch number: 20635);
[0081] (2) Provide the chromatographic column as the prewash column and the analysis column, all are ion exchange resin columns, the prewash column used in this embodiment has a length of 10cm and a diameter of 4.6mm and a particle size of 4 μm, and an analysis column has a length of 20cm and a diameter of 4.6mm and a particle size 8μm, the ion exchange resin of the chromatographic column is a special resin for Biochrom30+ high-...
Embodiment 3
[0094] Embodiment 3, use amino acid analyzer to measure the tranexamic acid in the product
[0095] Test samples: drugs, tranexamic acid capsules, market sampling products, and unknown excipients.
[0096] (1) Analytical instrument amino acid analyzer is provided, and what this embodiment uses is Biochrom30+ high-efficiency amino acid automatic analyzer; The chromogenic agent ninhydrin used for detection is produced by British Biochrom Ltd. (specifically used batch number: 20635);
[0097] (2) Provide the chromatographic column as the prewash column and the analysis column, all are ion exchange resin columns, the prewash column used in this embodiment has a length of 10cm and a diameter of 4.6mm and a particle size of 4 μm, and an analysis column has a length of 20cm and a diameter of 4.6mm and a particle size 8μm, the ion exchange resin of the chromatographic column is a special resin for Biochrom30+ high-efficiency amino acid automatic analyzer;
[0098] (3) Provide mobile ...
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