Alkylated chitosan multifunctional hydrogel as well as preparation method and application thereof

Abstract

The invention discloses an alkylated chitosan multifunctional hydrogel as well as a preparation method and application thereof. The preparation method of the alkylated chitosan multifunctional hydrogel comprises the following steps: (1) preparing alkylated chitosan; (2) preparing an alkylated chitosan solution, and preparing a four-arm polyethylene glycol benzaldehyde solution; and (3) mixing thealkylated chitosan solution and the four-arm polyethylene glycol benzaldehyde solution, and performing gelatinization at room temperature. According to the method provided by the invention, an alkanechain is used to modify an amino group of chitosan to prepare the alkylated chitosan, the hydrophobic alkane chain and a hydrophobic cell membrane can be fixed to each other by hydrophobic interaction, so that blood cells can be fixed on the long chain of the chitosan, blood is coagulated, and bleeding is quickly stopped; and polyethylene glycol benzaldehyde is cross-linked through an imine bond to form the stronger-functional more-stable self-repairing hydrogel, and the hydrogel has the functions of concentrating the blood to stop bleeding, absorbing exudate, and promoting wound repair of a hydrogel.

Description

technical field [0001] The invention belongs to the field of medical devices, and relates to an alkaneated chitosan multifunctional hydrogel and its preparation method and application, in particular to an alkaneated chitosan multifunctional hydrogel and its preparation method and application. Background technique [0002] 1. Open abdominal therapy is an important means of critical illness treatment [0003] Open abdominal therapy refers to the method of actively opening the abdominal cavity in the treatment of critical patients or closing the abdominal cavity with temporary closure materials without suturing the incision after abdominal surgery. Complications such as external fistula can be divided into three stages, which are early open and temporary abdominal closure stage, mid-term maintenance stage, and late digestive tract and abdominal wall reconstruction stage. This therapy implements the concept of damage control, and has become an important clinical treatment for s...

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Problems solved by technology

[0004] 2. Insufficient protective measures for exposed wounds after abdominal cavity opening

In the field of open abdominal cavity treatment, it is improved to cover a layer of plastic or silicone film on the surface of the exposed intestine to avoid direct contact between the sponge in the negative pressure device and the intestine, but due to its poor biocompatibility, poor air permeability, non-degradable, and no antibacterial properties , can only provide simple physical protection, but cannot promote intestinal granulation tissue proliferation and wound repair, the incidence of EAF is still high, and the protective effect is very limited

The occurrence of EAF cannot be avoided after negative pressure assisted abdominal closure

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