Quality monitoring method of preparation process of condensed pills of cyperus and amomum stomach nourishing pills

Abstract

The invention relates to a quality monitoring method of the preparation process of condensed pills of cyperus and amomum stomach nourishing pills. According to the quality monitoring method of the preparation process of the condensed pills of the cyperus and amomum stomach nourishing pills, the problem of rapid quality detection of the condensed pills of the cyperus and amomum stomach nourishing pills in the process of online production is effectively solved; samples with different water extraction time and concentration time are scanned by a near-infrared spectrometer to obtain original spectral data of the samples; the collected content of hesperidin and magnolol in corrected samples is determined by a high performance liquid chromatography (HPLC); a calibration set and a validation setare selected through the content of indexity components; the spectral data is subjected to pre-processing and spectral area selection; the content measured by the HPLC is taken as a reference value, acorrected sample set characteristic spectrum and the reference value are combined by the partial least squares to establish a multivariate calibration model of a near infrared reflectance spectroscopy (NIRS), and the model is verified; the NIRS is input the calibration model, and a NIRS predicted value and the HPLC reference value are analyzed; and the predicted value of the validation sample setis compared with the content of the hesperidin and the magnolol measured by the HPLC, the calibration model is monitored, and whether the validation sample set is a foul territory point or not is measured.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for monitoring the quality of Xiangsha Yangwei Pills (concentrated pills) in the preparation process of the Xiangsha Yangwei Pills (concentrated pills) for on-line detection and quality control by using near-infrared spectroscopy. Background technique [0002] Xiangsha Yangwei Pills (Concentrated Pills) are recorded in the 2015 edition of "Chinese Pharmacopoeia". It is mainly used for stomach pain and fullness caused by deficiency of stomach yang and stagnation of dampness and qi. The preparation is evolved from a traditional Chinese medicine prescription, has quick onset, good curative effect and low side effects, and is widely used clinically. [0003] The prescription of Xiangsha Yangwei Pill (concentrated pill) is complex and contains many kinds of medicinal materials. There are currently 13 samples of manufacturers on the market, and the content of chemical components meets...

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Problems solved by technology

[0005] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a quality monitoring method for the preparation process of Xiangsha Yangwei Pill Concentrated Pills, which can effectively solve the problem of rapid monitoring of Xiangsha Yangwei Pill Concentrated Pills in the online production process. Quality inspection to overcome the problems of cumbersome traditional methods, high production costs, low efficiency, and excessive waste of raw materials

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