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Application of ultra-small cerium oxide nanocrystal modified by phospholipid and polyethylene glycol

A polyethylene glycol, ultra-small technology, applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve problems such as interference with mitochondrial electron transport chain, damage to mitochondrial respiration, oxidative stress response, etc., to achieve good removal of cells, The effect of uniform and controllable particle size and high biological safety

Active Publication Date: 2019-05-28
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although protein adducts are not sufficient to cause direct cell death, cellular protein binding, particularly mitochondrial protein adducts, impairs mitochondrial respiration and causes oxidative stress
At the same time, they are known to interfere with the mitochondrial electron transport chain (ETC), causing electrons to leak from the chain and finally leading to the formation of ROS

Method used

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  • Application of ultra-small cerium oxide nanocrystal modified by phospholipid and polyethylene glycol
  • Application of ultra-small cerium oxide nanocrystal modified by phospholipid and polyethylene glycol
  • Application of ultra-small cerium oxide nanocrystal modified by phospholipid and polyethylene glycol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Synthesis of ultra-small cerium oxide nanocrystals:

[0034] Add 0.4g of cerium acetate hydrate and 3.2g of oleylamine to 15ml of xylene and stir, increase the temperature to 90°C at a rate of 2°C per minute, and stir for 4 hours to form a complex; inject 1ml of deionized water into the inert In the gas protection reaction system, aging for three hours, precipitation with anhydrous ether, and centrifugation to obtain ultra-small cerium oxide nanocrystals.

[0035] The morphology of ultra-small cerium oxide nanocrystals is characterized by transmission electron microscope, such as figure 1 As shown, the particle size is about 0.1-10 nm.

[0036] (2) Synthesis of ultra-small cerium oxide nanocrystals modified by phospholipid polyethylene glycol:

[0037] Add 0.01 g of phosphate polyethylene glycol (molecular weight 2000) and 2 mg of ultra-small cerium oxide nanocrystals to 5 ml of chloroform, and sonicate for 3 minutes in a water bath ultrasonic pot. After the above mixed li...

Embodiment 2

[0040] (1) Synthesis of ultra-small cerium oxide nanocrystals:

[0041] Add 0.4g of cerium acetate hydrate and 3.2g of oleylamine into 15ml of xylene and stir, increase the temperature to 95°C at a rate of 2°C per minute, and stir for 6 hours to form a complex; inject 1ml of deionized water into the inert In the gas protection reaction system, aging for three hours, precipitation with anhydrous ether, and centrifugation to obtain ultra-small cerium oxide nanocrystals.

[0042] (2) Synthesis of ultra-small cerium oxide nanocrystals modified by phospholipid polyethylene glycol:

[0043] Add 0.01 g of phosphate polyethylene glycol (molecular weight 2000) and 2 mg of ultra-small cerium oxide nanocrystals to 5 ml of chloroform, and sonicate for 5 minutes in a water bath ultrasonic pot. After the above-mentioned mixed solution is rotary steamed at 50 degrees Celsius for 1.5 hours, 1 ml of deionized water is added for hydration to obtain ultra-small cerium oxide nanocrystals modified with ...

Embodiment 3

[0045] (1) Synthesis of ultra-small cerium oxide nanocrystals:

[0046] Add 0.4g of cerium acetate hydrate and 3.2g of oleylamine to 15ml of xylene and stir, increase the temperature to 85°C at a rate of 2°C per minute, and stir for 3 hours to form a complex; inject 1ml of deionized water into the inert In the gas protection reaction system, aging for three hours, precipitation with anhydrous ether, and centrifugation to obtain ultra-small cerium oxide nanocrystals.

[0047] (2) Synthesis of ultra-small cerium oxide nanocrystals modified by phospholipid polyethylene glycol:

[0048] 0.01 g of phosphate polyethylene glycol (molecular weight 2000) and 2 mg of ultra-small cerium oxide nanocrystals were added to 5 ml of chloroform, and ultrasonicated in a water bath ultrasonic pot for 30 minutes. After the above-mentioned mixed solution is rotary steamed at 50 degrees Celsius for 2.5 hours, 1 ml of deionized water is added for hydration to obtain ultra-small cerium oxide nanocrystals mo...

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Abstract

The invention relates to application of an ultra-small cerium oxide nanocrystal modified by phospholipid and polyethylene glycol, in particular to application of the ultra-small cerium oxide nanocrystal modified by the phospholipid and the polyethylene glycol in preparation of drugs for resisting acute liver injuries caused by acetaminophen. The ultra-small cerium oxide nanocrystal modified by thephospholipid and the polyethylene glycol can have various anti-oxidation mimic enzyme activities, and can effectively reduce the ultrahigh ROS level in the body, relieve inflammatory reactions and treat the acute liver injuries caused by APAP (N-acetyl-p-aminophenol).

Description

Technical field [0001] The invention relates to the application of nano-biological materials, in particular to the application of ultra-small cerium oxide nanocrystals modified by phospholipid polyethylene glycol in the preparation of drugs for resisting acute liver injury caused by acetaminophen. Background technique [0002] Drug-induced liver injury refers to liver damage caused by the drug itself or its metabolites after the use of one or several drugs. Drug-induced liver injury can manifest as any type of acute or chronic liver disease currently known, but acute liver injury is the most common, accounting for more than 90% of the reported cases. A small number of patients can develop life-threatening fulminant or severe liver function Failure is the focus of clinical monitoring and prevention of drug hepatotoxicity. [0003] Acetaminophen is a mild antipyretic and analgesic. It is non-toxic at therapeutic doses, but for susceptible persons, or when the daily dose is greater t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/244A61K47/60A61P1/16B82Y5/00
Inventor 凌代舜翁勤洁李方园谢安邱月萍孙恒方春燕
Owner ZHEJIANG UNIV
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