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A magnetothermal responsive shape memory hierarchical porous nanocomposite bioscaffold based on 3D printing emulsion and its preparation and application

A 3D printing and nano-composite technology, which is applied in medical science, prosthesis, additive processing, etc., can solve the problems of photoinitiator bio-incompatible substance residues, limit the application of scaffolds, etc., and achieve good compatibility and dispersion , low equipment requirements and controllable preparation conditions

Active Publication Date: 2020-11-13
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the construction of multi-level porous scaffolds by 3D printing emulsions often involves UV light-cured emulsion continuous phase to fix the template, and the prepared scaffolds involve the residue of bio-incompatible substances such as photoinitiators, monomers or cross-linking agents, which limits the construction. Application of scaffolds in biomedical fields such as tissue engineering
In addition, based on the 3D printing emulsion template and does not involve UV light-cured emulsion continuous phase, it is effective, convenient and controllable to construct a composite hierarchical porous bioscaffold with magnetocaloric responsive shape memory magnetic nanoparticles / BSMPs, and explore its use as a tissue engineering scaffold Applications in biomedical fields such as minimally invasive implantation have not been reported so far

Method used

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  • A magnetothermal responsive shape memory hierarchical porous nanocomposite bioscaffold based on 3D printing emulsion and its preparation and application
  • A magnetothermal responsive shape memory hierarchical porous nanocomposite bioscaffold based on 3D printing emulsion and its preparation and application
  • A magnetothermal responsive shape memory hierarchical porous nanocomposite bioscaffold based on 3D printing emulsion and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Hydrophobic modification of ferroferric oxide nanoparticles: disperse 2 parts by mass of ferric oxide nanoparticles in 30 parts by volume of dichloromethane in an ice-water bath, then add 20 parts by volume of PLLA-COOH dichloromethane solution (Containing 2 mass parts PLLA-COOH, molecular weight 1.5×10 3 g / mol) mixed, ultrasonically dispersed and mixed evenly, and dried at room temperature to remove the solvent, and then the dry mixture was placed in a nitrogen atmosphere tube furnace for heat treatment at 200°C for 24h to obtain hydrophobically modified ferric oxide nanoparticles.

[0053] (2) Preparation of water-in-oil viscous Pickering emulsion: in an ice-water bath, 3 parts by volume of dichloromethane suspension was prepared by ultrasonication for 30 minutes, that is, the oil phase, in which polylactic acid-trimethylcarbonate Copolymer (molecular weight 5×10 4 g / mol, wherein the mol ratio of lactic acid and trimethylene carbonate is 70:30), the mass volume f...

Embodiment 2

[0057] (1) Hydrophobic modification of ferroferric oxide nanoparticles: disperse 2 parts by mass of ferric oxide nanoparticles in 30 parts by volume of dichloromethane in an ice-water bath, then add 20 parts by volume of PLLA-COOH dichloromethane solution (Containing 2 mass parts PLLA-COOH, molecular weight 5×10 3 g / mol) mixed, ultrasonically dispersed and mixed evenly, and dried at room temperature to remove the solvent, and then the dry mixture was placed in a nitrogen atmosphere tube furnace for heat treatment at 200°C for 30h to obtain modified ferric oxide nanoparticles.

[0058] (2) Preparation of water-in-oil viscous Pickering emulsion: in an ice-water bath, 4 parts by volume of dichloromethane suspension was prepared by ultrasonication for 30 minutes, i.e. the oil phase, in which polylactic acid-trimethylcarbonate Copolymer (molecular weight 5.3×10 4 g / mol, wherein the mol ratio of lactic acid and trimethylene carbonate is 80:20), the mass volume fraction of modified ...

Embodiment 3

[0061] (1) Hydrophobic modification of ferric oxide nanoparticles: disperse 2 parts by mass of ferric oxide nanoparticles in 30 parts by volume of dichloromethane in an ice-water bath, then add 20 parts by volume of PLLA-COOH dichloromethane solution (Containing 1.5 mass parts PLLA-COOH, molecular weight 1.5×10 3 g / mol) mixed, ultrasonically dispersed and mixed evenly, and dried at room temperature to remove the solvent, and then the dry mixture was placed in a nitrogen atmosphere tube furnace for heat treatment at 200°C for 30h to obtain modified ferric oxide nanoparticles.

[0062] (2) Preparation of water-in-oil viscous Pickering emulsion: in an ice-water bath, 6 parts by volume of dichloromethane suspension was prepared by ultrasonication for 30 minutes, that is, the oil phase, in which polylactic acid-glycolic acid-trimethyl Based carbonate copolymer (molecular weight is 3×10 4 g / mol, wherein the mol ratio of lactic acid, glycolic acid, and trimethylene carbonate is 80:1...

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Abstract

The invention belongs to the technical field of intelligent composite materials and biomedical materials, and discloses a magnetothermal response type shape memory hierarchical porous nano composite biological stent constructed based on a 3D printing emulsion and a preparation method and application of the stent. The method comprises the following steps that (1) magnetic inorganic nanoparticles are hydrophobically modified by using low molecular weight polylactic acid with terminal carboxyl groups to obtain hydrophobically modified magnetic inorganic nanoparticles; (2)the hydrophobically modified magnetic inorganic nanoparticles, a biodegradable shape memory polymer and a rheological agent are added into an organic solvent to form an oil phase; distilled water is added into the oil phase,and mixing and emulsification are carried out to obtain a water-in-oil type sticky Pickering emulsion; (3) the water-in-oil type sticky Pickering emulsion is taken as ink, and the three-dimensional porous emulsion stent is obtained through extrusion 3D printing, and drying is carried out to obtain the composite biological stent. The stent is of a hierarchical porous structure, has excellent biocompatibility, biodegradability, magnetothermal response shape memory property and the like, and is suitable for the field of biomedicine.

Description

technical field [0001] The invention belongs to the technical field of intelligent composite materials and biomedical materials, in particular to a magnetothermal responsive shape memory multi-level porous nanocomposite biological scaffold constructed based on 3D printing emulsion and its preparation method and application. Background technique [0002] Shape memory polymer is a kind of intelligent polymer material that can be fixed into a temporary shape under certain external conditions, and can return to the original shape when it is stimulated again. It has shape memory, large deformation, easy shaping, and high quality. Lightweight, cheap and corrosion-resistant. Among them, biodegradable shape memory polymers (BSMPs) have attracted much attention in the field of biomedicine due to their non-toxicity, good biocompatibility, biodegradability, and the degradation products can be absorbed or metabolized by the human body. And attention, is becoming one of the research hot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/50A61L27/02A61L27/18B33Y10/00B33Y80/00
Inventor 胡洋李耀宗周武艺杨卓鸿罗玉娜邹秀菊
Owner SOUTH CHINA AGRI UNIV
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