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A kind of preparation method of ethoxypropylene

A technology of ethoxypropylene and ethylene, applied in the field of preparation of ethoxypropylene, can solve the problems of large environmental pollution, long reaction route, many side reactions, etc., and achieve the effects of low raw material, high raw material utilization rate, and short process.

Active Publication Date: 2022-06-14
SHANDONG GUOBANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Method 1 and method 2 have long reaction routes and many side reactions in the reaction process, resulting in low yield, a lot of waste, and great environmental pollution.
Method three and method four These two methods are existing common methods, but the cost of raw material triethyl orthoformate and 2,2-diethoxypropane used in these two methods is all relatively high, needs investment relatively large, and return Low

Method used

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  • A kind of preparation method of ethoxypropylene

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Effect test

Embodiment 1

[0024] A method for preparing ethoxypropylene, comprising the following steps:

[0025] S0: In the preheating stage, take 65ml of acetone and 4L bottled ethylene gas as the raw materials for the reaction, and fill 60ml of the specific surface area of ​​≥200m2 in a jacketed tubular fixed-bed reactor with an inner diameter of 32mm 2 After the modified porous γ-alumina with a porosity of 60-70% / g and a porosity of 60-70%, nitrogen gas was introduced for 5 minutes to completely replace the air in the tubular fixed-bed reactor; then the tubular fixed-bed reactor was opened separately The heating device on the reactor and the condensing device at its lower end close to the outlet enable the modified catalyst porous γ-alumina in the tubular fixed bed reactor to be heated to 120°C;

[0026] S1: In the reaction stage, 65ml of acetone solution is used, and the acetone solution is transported to the coupling exchanger by a convection pump for vaporization and heating, and then heated to ...

Embodiment 2

[0030] A method for preparing ethoxypropylene, comprising the following steps:

[0031] S0: In the preheating stage, take 65ml of acetone and 4L bottled ethylene gas as the raw materials for the reaction, and fill 60ml of the specific surface area of ​​≥200m2 in a jacketed tubular fixed-bed reactor with an inner diameter of 32mm 2 After the modified porous γ-alumina with a porosity of 60-70% / g and a porosity of 60-70%, nitrogen gas was introduced for 5 minutes to completely replace the air in the tubular fixed-bed reactor; then the tubular fixed-bed reactor was opened separately The heating device on the reactor and the condensing device at its lower end near the outlet make the modified catalyst porous γ-alumina in the tubular fixed bed reactor heated to 130°C;

[0032] S1: In the reaction stage, 65ml of acetone solution is used, and the acetone solution is transported to the coupling exchanger for vaporization and heating by a convection pump, and then heated to 130°C throug...

Embodiment 3

[0036] A method for preparing ethoxypropylene, comprising the following steps:

[0037] S0: In the preheating stage, take 65ml of acetone and 4L bottled ethylene gas as the raw materials for the reaction, and fill 60ml of the specific surface area of ​​≥200m2 in a jacketed tubular fixed-bed reactor with an inner diameter of 32mm 2 After the modified porous γ-alumina with a porosity of 60-70% / g and a porosity of 60-70%, nitrogen gas is introduced for 5 minutes to completely replace the air in the tubular fixed bed reactor; then open the tubular fixed bed reactor respectively The heating device on the reactor and the condensing device at its lower end near the outlet make the modified catalyst porous γ-alumina in the tubular fixed bed reactor heated to 150°C;

[0038] S1: In the reaction stage, 65ml of acetone solution is used, and the acetone solution is transported to the coupling exchanger for vaporization and heating by a convection pump, and then heated to 150°C through a s...

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Abstract

The invention relates to a preparation method of ethoxypropylene, which solves the technical problems of high cost, low yield, low return, long reaction route, many by-products and environmental pollution in the prior art synthesis method of ethoxypropylene . The invention provides a preparation method of ethoxypropylene, which comprises the following steps: Step S1: In the reaction stage, acetone gas and ethylene gas are passed into a fixed-bed reactor, and the fixed-bed reactor is equipped with modified The catalyst catalyzes the addition reaction of ethylene under normal pressure of 120-180°C; step S2: product separation, the gas after the reaction in step S1 is condensed, separated, and recovered to obtain pure ethoxypropylene. The invention is widely used in the technical field of organic synthesis.

Description

technical field [0001] The invention relates to the technical field of organic synthesis, in particular to a preparation method of ethoxypropylene. Background technique [0002] 2-Ethoxypropene is an important pharmaceutical intermediate, which has gradually replaced 2-methoxypropene as the key intermediate in the synthesis of clarithromycin in China. Clarithromycin is a macrolide antibiotic used to treat upper and lower respiratory tract infections, subcutaneous soft tissue infections and other diseases. [0003] 2-Ethoxypropene is a simple alkenyl ether. There are four main synthetic methods in the prior art: method one, using acetaldehyde as a raw material, reacting with ethanol and hydrogen chloride to obtain α-chloroethyl ethyl ether, dibromo Ethyl ethyl ethers, 1-bromo-2-ethoxypropane, and finally the product. Method 2: Use ethyl acetoacetate as raw material, chlorinate with phosphorus trichloride to obtain β-chloro-2-butenoic acid, then react with sodium ethylate to...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C41/06C07C43/15
Inventor 张利东吴斌刘磊张建强张小垒
Owner SHANDONG GUOBANG PHARMA
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