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A controlled-release membrane capable of controlling the release of polypeptide drugs and its preparation method and application

A technology of controlled release membrane and polypeptides, which is applied in the fields of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of lack of controlled release membrane types, small selectivity, and obstacles to the development and utilization of polypeptide drugs, and is conducive to the development of Utilization, simple production process, good batch repeatability

Active Publication Date: 2021-08-27
SHANGHAI JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of controlled-release membrane performs well in controlling the release of small molecule drugs, it is difficult for peptide drugs with larger molecular weights to pass through such a small-sized mesh
Therefore, it is difficult for a controlled-release film containing only acrylate to exert a controlled release effect on the release of polypeptide drugs.
[0006] To sum up, in the existing studies on the administration methods of polypeptide drugs, there are few studies on the use of controlled-release membranes to control the release of polypeptide drugs, and the lack of types of controlled-release membranes and low selectivity provide great opportunities for polypeptide drugs. Wide range of development and utilization has brought great obstacles

Method used

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  • A controlled-release membrane capable of controlling the release of polypeptide drugs and its preparation method and application
  • A controlled-release membrane capable of controlling the release of polypeptide drugs and its preparation method and application
  • A controlled-release membrane capable of controlling the release of polypeptide drugs and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Preparation of Polyacrylate-Polyethylene Glycol 6000 / 400-MgO Controlled Release Membrane

[0042] Acrylate-(2-hydroxy-3-phenoxy)propyl, acrylate-4-hydroxybutyl, 1,6-hexanediol diacrylate, acrylate-2-(2-(2-ethylhexyloxy Base) ethoxy) ethyl ester was mixed uniformly according to the mass ratio of 9:9:1:1, then 3% benzophenone peroxide was added, stirred and dissolved, and mixed uniformly to obtain mixed solution A. According to the mass ratio of mixed solution A to PEG6000, PEG400, and magnesium oxide particles 82.5:5:5:7.5, accurately weigh PEG6000, PEG400, and magnesium oxide particles (50±10nm), and stir evenly to obtain the final mixture C. Take an appropriate amount of mixture C, evenly spread it in a stainless steel mold with a groove depth of 0.01 mm, and place it in an ultraviolet curing instrument to cure completely to obtain a polymer film. Carefully separate the polymer film from the stainless steel mold, then immerse the polymer film in a hydrochloric acid so...

Embodiment 2

[0044] Preparation of Polyacrylate-Polyethylene Glycol 10000 / 400-MgO Controlled Release Membrane

[0045] Mix acrylate-(2-hydroxy-3-phenoxy)propyl, 4-hydroxybutyl acrylate, and 1,6-hexanediol diacrylate in a mass ratio of 4:4:2, then add 5% Benzophenone peroxide was stirred and dissolved, and mixed uniformly to obtain mixed solution A. According to the mass ratio of mixed solution A to PEG10000, PEG400, and magnesium oxide particles 80:5:5:10, accurately weigh PEG6000, PEG400, and magnesium oxide particles (50±10nm), and stir evenly to obtain the final mixture C. Take an appropriate amount of mixture C, evenly spread it in a stainless steel mold with a groove depth of 0.01 mm, and place it in an ultraviolet curing instrument to cure completely to obtain a polymer film. Carefully separate the polymer film from the stainless steel mold, then immerse the polymer film in a hydrochloric acid solution with a concentration of 1.0 mol / L, and let it stand for 48 hours. After 48 hours...

Embodiment 3

[0047] Preparation of Polyacrylate-Polyethylene Glycol 400-MgO Controlled Release Membrane

[0048] Acrylate-(2-hydroxy-3-phenoxy)propyl, acrylate-4-hydroxybutyl, 1,6-hexanediol diacrylate, acrylate-2-(2-(2-ethylhexyloxy Base) ethoxy) ethyl ester was mixed uniformly according to the mass ratio of 9:9:1:1, then 3% benzophenone peroxide was added, stirred and dissolved, and mixed uniformly to obtain mixed solution A. According to the mass ratio of mixed solution A to PEG400 and magnesium oxide particles 80:5:15, accurately weigh PEG6000, PEG400 and magnesium oxide particles (50±10nm), and stir evenly to obtain the final mixture C. Take an appropriate amount of mixture C, evenly spread it in a stainless steel mold with a groove depth of 0.01 mm, and place it in an ultraviolet curing instrument to cure completely to obtain a polymer film. Carefully separate the polymer film from the stainless steel mold, then immerse the polymer film in a hydrochloric acid solution with a concent...

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Abstract

The invention relates to a controlled-release film capable of controlling the release of polypeptide drugs and its preparation method and application. The controlled-release film is prepared from the following components in parts by weight: 75-85 parts of acrylate monomers, photoinitiated 0.08-10 parts of agent, 0-85 parts of polyethylene glycol but not 0, 0-43 parts of nano-sized particles but not 0. The preparation method comprises the following steps: 1) mixing an acrylate monomer with a photoinitiator to obtain a mixed solution A; 2) mixing polyethylene glycol with the mixed solution A to obtain a mixed solution B; 3) mixing the nano-sized particles with Mix solution B to obtain mixture C; 4) Apply mixture C evenly on the mold, and place it under an ultraviolet lamp for photocatalytic reaction to obtain a polymer film; 5) Soak the polymer film in an acid solution to obtain a controlled release membrane. Compared with the prior art, the controlled-release membrane of the present invention is used to control the release of polypeptide drugs, and has the characteristics of easy adjustment of permeation rate, stable structure and good batch repeatability.

Description

technical field [0001] The invention belongs to the technical field of polymer membrane materials, and relates to a controlled-release membrane capable of controlling the release of polypeptide drugs, a preparation method and application thereof. Background technique [0002] Polypeptide substances are a class of substances composed of amino acids as the basic unit, with simple structure and strong physiological activity, and have obvious preventive and therapeutic effects on diseases. With the development of science and technology, polypeptide substances have successfully prevented and treated many diseases, such as diabetes, allergic diseases and immune diseases, etc., bringing good news to the majority of patients. Polypeptide drugs have gradually been recognized by people. growing. However, due to the digestion and degradation of the gastrointestinal tract and the first-pass effect of the liver, the oral bioavailability of polypeptide drugs is low. Excessive pain and r...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/10A61K38/28A61P3/10
CPCA61K9/7007A61K38/28A61K47/10A61K47/32A61P3/10
Inventor 毛振民史慧颖詹晓平
Owner SHANGHAI JIAOTONG UNIV
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