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A kind of medicament for preventing and treating apple ring spot and its preparation method and application

Active Publication Date: 2021-03-30
YUNCHENG UNIVERISTY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, chemical fungicides are mainly used to prevent and control ring ring disease in production. Fungicides such as mancozeb, carbendazim, thiophanate-methyl, thiophanate-methyl, and captafol are commonly used to prevent ring ring disease. They have been used for a long time These drugs prevent and control apple ring disease, and there will be problems of decreased drug resistance and sensitivity, and the drugs are easy to remain, and the residual pesticides will endanger human health.

Method used

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  • A kind of medicament for preventing and treating apple ring spot and its preparation method and application

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Effect test

Embodiment 1

[0026] Embodiment 1: Modified chitosan preparation one:

[0027] Add 80g of chitosan with a degree of deacetylation of 80% and a molecular weight of 6000 to 300ml of 2% acetic acid solution. The higher the degree of deacetylation of chitosan, the more free amino groups, the less easy it is to dissolve, so it is necessary to add acetic acid solution , Dissolve chitosan in acetic acid solution, configure to form a 2wt% chitosan solution, add 16g of 2-chloromethylbenzimidazole at room temperature, stir and heat to 80°C, 2-chloromethylbenzimidazole belongs to imidazole A compound with a strong bactericidal effect, dissolved in hot water, after 2-chloromethyl benzimidazole is completely dissolved, stop heating, and drop 2wt% nitric acid and 3wt% hydrochloric acid in a volume ratio of 1:1 under nitrogen atmosphere 50ml of the mixed solution prepared according to the ratio, cooled to 50°C, added 0.5g of cerium ammonium nitrate initiator, and stirred at 50°C for 10h at a rate of 200r / ...

Embodiment 2

[0029] Embodiment 2: modified chitosan preparation two:

[0030] The degree of deacetylation is 90%, and the molecular weight is 60g chitosan of 7000 is added in the acetic acid solution of 250ml 2%, is configured into the chitosan solution of 3wt% subsequently, adds 30g 2-chloromethylbenzimidazole at normal temperature , stirring and heating to 80°C, after 2-chloromethylbenzimidazole is completely dissolved, stop heating, and under nitrogen atmosphere, drop 50ml of a mixed solution prepared by 2wt% nitric acid and 3wt% hydrochloric acid according to the volume ratio of 1:1 , cooled to 50°C, added 0.3g cerium ammonium nitrate initiator, and stirred at 50°C for 11h at a rate of 200r / min, then added 70ml 45wt% formic acid, 21ml ethylene glycol, 50ml ethanol, 100ml deionized water, and heated Reflux to 80°C for 24 hours, stop the reaction, cool to room temperature, filter the product with deionized water, and dry at 40°C to obtain the medicament.

Embodiment 3

[0031] Embodiment 3: modified chitosan preparation three:

[0032] The deacetylation degree is 85%, the 100g chitosan that molecular weight is 6000 is added in the acetic acid solution of 350ml 2%, is configured into the chitosan solution of 3wt% subsequently, adds 30g 2-chloromethyl benzimidazole at normal temperature, Stir and heat to 80°C. After 2-chloromethylbenzimidazole is completely dissolved, stop heating, and drop 70ml of a mixed solution prepared by 2wt% nitric acid and 3wt% hydrochloric acid in a volume ratio of 1:1 under a nitrogen atmosphere. Cool down to 50°C, add 0.5g cerium ammonium nitrate initiator, stir and react at 50°C for 11h at a rate of 200r / min, then add 100ml 45wt% formic acid, 30ml ethylene glycol, 50ml ethanol, 100ml deionized water, and heat to After reflux at 75°C for 20 hours, stop the reaction, cool to room temperature, filter the product with suction, wash it with deionized water, and dry it at 40°C to obtain the drug.

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Abstract

The invention discloses a medicament for preventing and treating apple ring spot and its preparation method and application, belonging to the technical field of fungicides. The medicament includes a gel skeleton and modified chitosan, and the modified chitosan is chitosan Sugar-grafted imidazole compounds are modified by formic acid, the gel skeleton raw materials include guar gum, cellulose acrylic acid, and carbopol, and the imidazole compounds are 2-chloromethylbenzimidazole. The medicament is mixed with water to form a gel, and then applied to the lesion where the tumor has been scraped. The medicament disclosed by the invention is specially used to prevent apple ring disease, and has good drug effect, long drug effect time and slow drug resistance.

Description

technical field [0001] The invention relates to the technical field of fungicides, in particular to a medicament for preventing and treating apple ring spot and its preparation method and application. Background technique [0002] Apple ring disease includes two damage symptoms: branch ring disease and fruit ring disease. Branch ring spot, after the ring spot fungus invades the lenticels of apple branches, small protruding nodules are formed on the lenticels, which begin to expand in the second year, and generally become diseased tumors in the third year, typical nodules The diameter is 0.3-3 centimeters, and cracks and warped skins will appear around the tumors on the branches in three or four years. If meet suitable weather at the same time, scattered black small dots (conidiophores) will appear around the central protrusion, and the bacteria spores will start to re-infect. When the pomegranate lesions on the trunk and main branches are severe, the bark of the diseased p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/52A01N43/16A01N25/24A01P3/00A01G13/00
CPCA01G13/00A01N25/24A01N43/16A01N43/52
Inventor 冯宝珍李培谦
Owner YUNCHENG UNIVERISTY
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