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Metal doped ferrite nano material and preparation method of magnetic nano particles containing same and application thereof

A technology of magnetic nanoparticles and metal doping, applied in biochemical equipment and methods, preparations for in vivo experiments, magnetic materials, etc., can solve the problems of low longitudinal relaxation rate, transverse longitudinal relaxation rate ratio, etc.

Pending Publication Date: 2019-04-16
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, common iron oxide nanoparticles are not suitable as MRI T1 contrast agents: MRI T1 contrast agents should have a high longitudinal relaxation rate (r1) and a low transverse longitudinal relaxation rate ratio (r2 / r1), highlighting MRI T1 contrast effect (maximized)

Method used

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  • Metal doped ferrite nano material and preparation method of magnetic nano particles containing same and application thereof
  • Metal doped ferrite nano material and preparation method of magnetic nano particles containing same and application thereof
  • Metal doped ferrite nano material and preparation method of magnetic nano particles containing same and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0115] (1) Weigh 1g of NaOH in a 100ml beaker, add 10ml of oleic acid and 10ml of ethanol therein, and stir on a magnetic stirrer until the NaOH is dissolved and dispersed evenly to obtain solution a;

[0116] (2) Weigh 1.73mM Fe 2+ Salt and 0.267mM Zn 2+ Salt, dissolved in 20ml ultrapure water, and ultrasonicated until all the salt is dissolved and mixed evenly to obtain solution b;

[0117] (3) At room temperature, the above solution b was added dropwise to solution a, and magnetically stirred until the solution turned brown and clear, to obtain solution c;

[0118](4) Take 30ml of c solution and transfer it to a polytetrafluoroethylene liner, put it in a reactor and seal it, put the reactor into an oven, and react at a constant temperature of 230°C for 15 hours;

[0119] (5) After the reaction is completed, the reactor is cooled to room temperature, and the nanoparticles at the bottom of the polytetrafluoroethylene liner are dissolved in chloroform and taken out into a 50...

Embodiment 2

[0126] (1) Weigh 1g of NaOH in a 100ml beaker, add 10ml of oleic acid and 10ml of ethanol therein, and stir on a magnetic stirrer until the NaOH is dissolved and dispersed evenly to obtain solution a;

[0127] (2) Weigh 1.73mM Fe 2+ Salt and 0.534mM Zn 2+ Salt, dissolved in 20ml ultrapure water, and ultrasonicated until all the salt is dissolved and mixed evenly to obtain solution b;

[0128] (3) At room temperature, the above solution b was added dropwise to solution a, and magnetically stirred until the solution turned brown and clear, to obtain solution c;

[0129] (4) Take 30ml of c solution and transfer it to a polytetrafluoroethylene liner, put it in a reactor and seal it, put the reactor into an oven, and react at a constant temperature of 230°C for 15 hours;

[0130] (5) After the reaction is completed, the reactor is cooled to room temperature, and the nanoparticles at the bottom of the polytetrafluoroethylene liner are dissolved in chloroform and taken out into a 5...

Embodiment 3

[0138] (1) Weigh 1g of NaOH in a 100ml beaker, add 10ml of oleic acid and 10ml of ethanol therein, and stir on a magnetic stirrer until the NaOH is dissolved and dispersed evenly to obtain solution a;

[0139] (2) Weigh 1.73mM Fe 2+ Salt and 0.801mM Zn 2+ Salt, dissolved in 20ml ultrapure water, and ultrasonicated until all the salt is dissolved and mixed evenly to obtain solution b;

[0140] (3) At room temperature, the above solution b was added dropwise to solution a, and magnetically stirred until the solution turned brown and clear, to obtain solution c;

[0141] (4) Take 30ml of c solution and transfer it to a polytetrafluoroethylene liner, put it in a reactor and seal it, put the reactor into an oven, and react at a constant temperature of 230°C for 15 hours;

[0142] (5) After the reaction is completed, the reactor is cooled to room temperature, and the nanoparticles at the bottom of the polytetrafluoroethylene liner are dissolved in chloroform and taken out into a 5...

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Abstract

The invention discloses a metal doped ferrite nano material and a preparation method of magnetic nano particles containing the same and application and products thereof. The metal doped ferrite is a metal doped iron oxides with the chemical general formula of MxFe3-xO4, wherein M represents metal elements selected from a VIIB group, a VIII group or a IIB group, X represents the concentration rangeof doping metal, and 0<x<=4. A Fe-Au nano composite material is applied to magnetic resonance imaging so that a high-quality MRI contrast medium with significantly excellent imaging performance, highmagnetic sensitivity and abundant MR T1 and T2 weight imaging signals, the distinguishing and inspecting of severe diseases of tumors, cardiovascular diseases, neural system diseases, skeleton musclediseases and the like can be improved, and therefore the error of medical imaging inspecting and the treatment cost are significantly reduced.

Description

technical field [0001] The invention relates to the field of medical nanomaterials, in particular to a preparation method and application of magnetic nanoparticles. Background technique [0002] Non-invasive and visualized molecular imaging technology can not only reduce the damage to the human body, but also provide effective diagnostic information for various diseases. Therefore, it is favored more and more in our daily life. At present, the popular molecular diagnostic imaging techniques in medicine mainly include: positron emission tomography (PET), single photon emission computed tomography (SPECT), X-ray computed tomography (CT), magnetic resonance imaging (MRI), optical imaging (OI) and ultrasound imaging (US). Biomedical imaging technology can provide comprehensive information on life form, structure, metabolism and function for the clinical diagnosis and treatment of cancer by assisting traditional surgery, chemotherapy and radiotherapy, etc., and can further reali...

Claims

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Application Information

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IPC IPC(8): C01G49/00B82Y40/00B82Y30/00H01F1/00A61K49/18A61K47/02C12N5/00
CPCA61K47/02A61K49/1818A61K49/1851H01F1/0018C12N5/00C01G49/0018C01G49/0063C01G49/0072C12N2509/00C01P2006/42C01P2004/64
Inventor 吴爱国马园园陈天翔杨方
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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