Preparation, product and application of fluorescently labeled polyester/periodic mesoporous bone filling composites with degradable rate

A fluorescent labeling and degradation rate technology, which is applied in medical science, prosthesis, tissue regeneration, etc., can solve the problems that the degradation rate and bone healing rate cannot be directly observed, the mechanical properties do not match natural bone, and the degradation time is uncontrollable. , to achieve the effects of increasing dispersion uniformity and organic-inorganic interfacial compatibility, overcoming molecular weight loss, and improving luminous efficiency and stability

Active Publication Date: 2021-06-04
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the degradation time of polylactic acid materials as bone repair materials is uncontrollable, the degradation rate of implant materials and the rate of bone healing cannot be directly observed, the mechanical properties do not match natural bone, and the degradation products of implant materials are acidic and easy to cause inflammation, etc. insufficient

Method used

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  • Preparation, product and application of fluorescently labeled polyester/periodic mesoporous bone filling composites with degradable rate
  • Preparation, product and application of fluorescently labeled polyester/periodic mesoporous bone filling composites with degradable rate
  • Preparation, product and application of fluorescently labeled polyester/periodic mesoporous bone filling composites with degradable rate

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Embodiment 1

[0039] A method for preparing a polyester / periodic mesoporous bone-filling composite material whose degradation rate can be fluorescently marked. The biodegradable polylactic acid-based random copolymer is used as the matrix, and the modified rare earth periodic mesoporous fluorescent material is used as the matrix. An enhancer and a fluorescent agent are used to prepare a composite material with self-enhancement effect and degradation rate that can be fluorescently marked, including the following steps:

[0040] 1) Preparation of rare earth periodic mesoporous nanoparticles with fluorescent properties:

[0041] First, carry out amination modification on the rare earth complex: add 20 mL tetrahydrofuran solvent into a three-necked flask, then add 2 mmol 0.5366 g N,N'-bis(salicylidene)ethylenediamine (Salen), and wait until it is completely dissolved Finally, 4 mmol1.0 g triethoxysilyl isopropyl isocyanate (TEPIC) was added, condensed and refluxed for 12 h under the protection ...

Embodiment 2

[0051] Approximate with embodiment 1 step, comprise the following steps:

[0052] 1) Preparation of rare earth periodic mesoporous nanoparticles with fluorescent properties:

[0053]First, carry out amination modification on the rare earth complex: add 20 mL tetrahydrofuran solvent into a three-necked flask, then add 2 mmol 0.5366 g N,N'-bis(salicylidene)ethylenediamine (Salen), and wait until it is completely dissolved Finally, 4 mmol1.0 g triethoxysilyl isopropyl isocyanate (TEPIC) was added, condensed and refluxed for 12 h under the protection of nitrogen at 65 °C, and finally the obtained solution was separated and purified by a rotary evaporator to obtain a light yellow viscous The viscous liquid is denoted as Salen-Si; followed by in situ synthesis of periodic mesoporous graft complex composites: the template agent cetyltrimethylammonium bromide (CTAB) (0.416 g) and NaOH (0.1888 g) were dissolved In deionized water (12.72 mL), a mixed solution of Salen-Si and 1,2-bis(tr...

Embodiment 3

[0061] Approximate with embodiment 1 step, comprise the following steps:

[0062] 1) Preparation of rare earth periodic mesoporous nanoparticles with fluorescent properties:

[0063] First, carry out amination modification on the rare earth complex: add 20 ml tetrahydrofuran solvent into a three-necked flask, then add 2 mmol 0.5366 g N,N'-bis(salicylidene)ethylenediamine (Salen), and wait until it is completely dissolved Finally, 4 mmol1.0 g triethoxysilyl isopropyl isocyanate (TEPIC) was added, condensed and refluxed for 12 h under the protection of nitrogen at 65 °C, and finally the obtained solution was separated and purified by a rotary evaporator to obtain a light yellow viscous The viscous liquid is denoted as Salen-Si; followed by in situ synthesis of periodic mesoporous graft complex composites: the template agent cetyltrimethylammonium bromide (CTAB) (0.416 g) and NaOH (0.1888 g) were dissolved In deionized water (12.72 mL), then a mixed solution of Salen-Si and 1,2-...

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Abstract

The invention relates to the preparation, product and application of a polyester / periodic mesoporous bone filling composite material whose degradation rate can be fluorescently marked. Firstly, rare earth periodic mesoporous nanoparticles with fluorescent properties were synthesized, then the rare earth periodic mesoporous nanoparticles were chemically modified with low molecular weight poly-L-lactic acid as a modifier, and finally added to the polyester matrix by solution blending middle. The product obtained by the above method and the application of the product as a composite bone filling material in bone repair are also provided. The fluorescent mesoporous material obtained by the method of the invention is evenly dispersed in the organic matrix, the mechanical properties of the polyester base are greatly improved, and the degradation behavior of the composite bone filling material can be monitored in real time. The preparation process is simple, and it can be used as a bone filling material for load-bearing bone parts with high performance index requirements. The obtained composite material can meet the requirement of clinical application.

Description

technical field [0001] The invention relates to a preparation method of a polyester / periodic mesoporous bone filling composite material whose degradation rate can be fluorescently marked and its product and application, in particular to a biodegradable polylactic acid-based random copolymer as a matrix, with The modified rare earth periodic mesoporous is used as a reinforcing agent and a fluorescent agent, and a composite material with self-reinforcing effect and degradation rate that can be marked by fluorescence is prepared. The invention belongs to the field of biomedical composite materials. Background technique [0002] With the development of medicine and materials science, the clinical application of biodegradable medical materials is becoming more and more common. It is used to replace stainless steel and other metal materials for fixation after fracture reduction, avoiding the risk of secondary surgery and reducing the pain of patients. Polylactic acid and polylac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/58A61L27/50A61L27/18C08G63/08
CPCA61L27/18A61L27/50A61L27/58A61L2430/02C08G63/08C08L67/04
Inventor 何丹农王杰林于建树王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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