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Dual-mode imaging photothermoluminescence probe and preparation method thereof and application thereof

A dual-mode imaging and luminescent probe technology, applied in the field of nanoprobes, can solve the problems of unstable biological applications and singleness of nanomaterials, and achieve the effects of inhibiting the growth of tumor cells, improving stability, and stabilizing chemical properties

Inactive Publication Date: 2019-03-29
SHENZHEN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the above-mentioned deficiencies of the prior art, provide a kind of dual-mode imaging photothermoluminescent probe and preparation method thereof, to solve the problem of existing bismuth selenide (BiSe) 2 Se 3 ) The technical problems of the instability of nanomaterials and the singleness of their biological applications

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  • Dual-mode imaging photothermoluminescence probe and preparation method thereof and application thereof
  • Dual-mode imaging photothermoluminescence probe and preparation method thereof and application thereof

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preparation example Construction

[0030] On the other hand, on the basis of the above-mentioned dual-mode imaging photothermal luminescence probe, the embodiment of the present invention also provides a preparation method of the dual-mode imaging photothermal luminescence probe. The process of the preparation method of the dual-mode imaging photothermal luminescence probe of the embodiment of the present invention is as follows figure 2 As shown, it includes the following steps:

[0031] After mixing and reacting the photothermal nanomaterial containing bismuth selenide in a self-polymerization reaction solution containing dopamine, a near-infrared dye is added for mixing treatment to obtain a dual-mode imaging photothermal luminescence probe.

[0032] Wherein, in the process of mixing and reacting the photothermal nanomaterial in the self-polymerization reaction solution of dopamine, dopamine will undergo self-polymerization reaction in the reaction solution to generate polydopamine to coat the surface of the phot...

Embodiment 1

[0041] This embodiment provides a dual-mode imaging photothermal luminescence probe and a preparation method thereof. The structure of the dual-mode imaging photothermal luminescence probe is as figure 1 As shown, the TEM photo is as figure 2 Shown. Bi 2 Se 3 Nanoparticle core body 1, coated on the Bi 2 Se 3 The dopamine coating layer 2 of the nanoparticle core 1 and the DYE-PEG near-infrared dye functional component 3 bound on the outer surface of the dopamine coating layer 2.

[0042] The preparation method of the dual-mode imaging photothermal luminescence probe includes the following steps:

[0043] d1: Synthetic Bi 2 Se 3 Nanosheets

[0044] First, the sodium borohydride and selenium powder were reacted in a 2:1 ratio to obtain a sodium selenium hydride solution; then 0.5 g of polyvinylpyrrolidone was dissolved in 50 ml of glycerol, added to a 200 ml round bottom flask, and then added to the bismuth nitrate , Stir at room temperature and heat to 200 degrees Celsius; then add ...

Embodiment 2

[0050] This embodiment provides a dual-mode imaging photothermal luminescence probe and a preparation method thereof. The structure of the dual-mode imaging photothermal luminescence probe is as figure 1 As shown, the TEM photo is as figure 2 Shown. Bi 2 Se 3 Nanoparticle core body 1, coated on the Bi 2 Se 3 The dopamine coating layer 2 of the nanoparticle core 1 and the DYE-PEG near-infrared dye functional component 3 bound on the outer surface of the dopamine coating layer 2.

[0051] The preparation method of the dual-mode imaging photothermal luminescence probe includes the following steps:

[0052] d1: Synthetic Bi 2 Se 3 Nanosheets

[0053] First, the sodium borohydride and selenium powder were reacted in a 2:1 ratio to obtain a sodium selenium hydride solution; then 0.5 g of polyvinylpyrrolidone was dissolved in 50 ml of glycerol, added to a 200 ml round bottom flask, and then added to the bismuth nitrate , Stir at room temperature, and heat to 200 degrees Celsius; then add...

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Abstract

The present invention discloses a dual-mode imaging photothermoluminescence probe and a preparation method thereof and an application thereof. The dual-mode imaging photothermoluminescence probe comprises a core body and a coating layer coated on the core body, the core body is a photothermal material, the photothermal material comprises a bismuth selenide nano material, a material of the coatinglayer comprises polydopamine, and a near-infrared dye is bonded to an outer surface of the coating layer facing away from the core body. The dual-mode imaging photothermoluminescence probe has a strong photothermal effect, is stable in structures and chemical properties, has near-infrared two-region imaging and CT imaging functions, and can effectively inhibit tumor cell growth. Moreover, the preparation method can effectively ensure stability of the structures and performances of the prepared dual-mode imaging photothermoluminescence probe, conditions are easy to control, and the preparationmethod effectively improves production efficiency and reduces economic costs.

Description

Technical field [0001] The invention belongs to the technical field of nano probes, and particularly relates to a dual-mode imaging photothermal luminescence probe and a preparation method and application thereof. Background technique [0002] In the past decades of human struggle with cancer, accurate early diagnosis and treatment of cancer remains a huge challenge. Due to the low sensitivity and non-specificity of the detection method, many cancers are already in the middle and advanced stages when they are discovered. At this time, the tumor has grown very large, and with the metabolism, there is a high possibility that it has metastasized to various organs and tissues of the body. Therefore, it is very urgent to develop a multi-functional diagnosis and treatment method to overcome the shortcomings of a single method. [0003] With the development of nanomaterials and nanotechnology, the development of multifunctional nanomaterials for diagnosis and treatment has attracted more...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/00A61K49/04A61K9/51A61K47/34A61K47/24A61P35/00
CPCA61K9/5146A61K41/0052A61K49/0002A61K49/0019A61K49/0093A61K49/0485A61P35/00
Inventor 王丹薛彬宋军屈军乐
Owner SHENZHEN UNIV
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