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A kind of preparation method of gold nanoparticles

A technology of gold nanoparticles and chloroauric acid, which is applied in the direction of nanotechnology, can solve the problems of limiting the biological application of gold nanoparticles, easy aggregation of gold particles, and harsh reaction conditions, and achieve good surface plasmon resonance properties, biophase Good capacitance and short response time

Active Publication Date: 2022-01-25
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although the gold nanomaterials obtained by physical methods are relatively pure and will not introduce other impurities, the reaction conditions are harsh, the cost is relatively high, and the particle size distribution of the product is wide; the cost of chemical methods is relatively low, and the product morphology, particle size It can be controlled by changing the synthesis conditions, but the general chemical method has many steps, takes a long time, and is easy to introduce other organic impurities, and the gold particles reduced in water are easy to agglomerate. Although the organic protective colloid can control the nucleation and prevent agglomeration, but Its toxicity greatly limits the biological application of gold nanoparticles

Method used

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  • A kind of preparation method of gold nanoparticles
  • A kind of preparation method of gold nanoparticles
  • A kind of preparation method of gold nanoparticles

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Experimental program
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Effect test

Embodiment 1

[0033] Dissolve the synthetic hectorite powder in deionized water to form a 1mg / ml synthetic hectorite dispersion sol. After ultrasonication for 30min, let it stand for 24h to obtain the synthetic hectorite dispersion. Take 10ml and add Ionized water to 100ml, add to beaker and stir under stirrer. Add 30 μl of 126 mmol / l chloroauric acid solution to the stirred 100 mL of the synthetic hanklotite dispersion. After stirring for 10 min, 100 μl of 188 mmol / l CTAC solution was added. After ultrasonication for 5 min, return to the stirring plate, add 100 μl of 126 mmol / l AA under vigorous stirring, and the reaction solution gradually turns purple. After stopping the reaction, the resulting solution was centrifuged at 4000 rpm for 10 minutes with a centrifuge, the supernatant was discarded, and the resulting precipitate was ultrasonically dispersed into 10 ml of ultrapure water to obtain gold nanoparticles.

[0034] The gold sol of gained is purple, and average particle size 76nm, ...

Embodiment 2

[0036] Change concentration of chloroauric acid solution into 40mmol / l in embodiment 1, keep other reaction conditions constant, the gold sol of gained is pink, average particle diameter 69nm, dispersion index PDI is 0.565, and ultraviolet-visible characteristic absorption peak is 546.5 nm (such as image 3 shown), the separation of the upper and lower layers was not obvious during centrifugation.

Embodiment 3

[0038] Change concentration of chloroauric acid solution into 600mmol / l in embodiment 1, keep other reaction conditions constant, the gold sol of gained is unclear pink, average particle diameter 89nm, dispersion index PDI is 0.345, ultraviolet-visible characteristic absorption peak 543nm (as Figure 4 Shown), the upper layer is still obviously pink after centrifugation.

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Abstract

The invention discloses a method for preparing gold nanoparticles. In the method, ascorbic acid is used as a reducing agent, cetyltrimethylammonium chloride is used as a protective agent, and chloroauric acid is reduced to monodisperse in a clay dispersion system. irregular gold nanoparticles. The preparation method provided by the invention has the advantages of simple process, convenient operation, cheap and readily available raw materials, non-toxic reagents, mild conditions and short reaction time. The polygonal gold nanoparticles prepared by the invention have structural anisotropy, large size and good dispersibility. The method of the invention is easy to operate, mild in conditions, cheap and easy to obtain artificially synthesized laponite materials, and can regulate the size and shape of gold particles.

Description

(1) Technical field [0001] The invention relates to a method for preparing gold nanoparticles in artificially synthesized hectorite dispersion. (2) Background technology [0002] Gold nanoparticles are one of the most studied nanomaterials, because of their biocompatibility, chemical stability and plasmonic tunability, they are widely used in biosensing, magnetic resonance imaging, photodynamic therapy, photoacoustic imaging, photochemical and Electrochemical catalysis, optoelectronic devices and other fields have broad application prospects. In particular, the plasmons of anisotropic gold nanoparticles can be tuned to the near-infrared (NIR) region, where the excellent tissue penetration ability in this spectral range can play a special role in in vivo applications (Li,N ., Zhao, P., & Astruc, D. (2014). Anisotropic gold nanoparticles: synthesis, properties, applications, and toxicity. Angewandte Chemie International Edition, 53(7), 1756-1789). [0003] There are many met...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B82Y40/00
CPCB82Y40/00B22F9/24
Inventor 周春晖张静张浩
Owner ZHEJIANG UNIV OF TECH
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