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Bullet-shaped non-spherical micro-particle and microcapsule, and preparation method thereof

A non-spherical, micro-particle technology, applied in the direction of microsphere preparation, microcapsule preparation, microcapsules, etc., can solve the problems of inability to achieve continuous preparation, inability to prepare bullet-shaped non-spherical microcapsules, and large shape resistance

Active Publication Date: 2019-03-19
四川大川合颐生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods have some shortcomings. The film-based stretching method of spherical microparticles cannot achieve continuous preparation, and requires a higher temperature to dissolve the internally embedded spherical microparticles, which is a cumbersome process.
The non-uniform photolithography method based on microfluidics is developed on the basis of entrapment photolithography, and cannot achieve continuous preparation
The bullet-shaped microparticles prepared by these two methods are actually in the shape of a truncated cone, and the shape resistance is relatively large, which is not conducive to improving their flow characteristics and movement speed in channels such as blood vessels.
These two methods are also unable to prepare bullet-shaped non-spherical microcapsules

Method used

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  • Bullet-shaped non-spherical micro-particle and microcapsule, and preparation method thereof
  • Bullet-shaped non-spherical micro-particle and microcapsule, and preparation method thereof
  • Bullet-shaped non-spherical micro-particle and microcapsule, and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] In this embodiment, bullet-shaped non-spherical microparticles are prepared, and the steps are as follows:

[0078] (1) Preparation of dispersed phase, continuous phase and shear phase fluid

[0079] Prepare the dispersed phase fluid: Dissolve polyethylene glycol diacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone and Pluronic F-127 in deionized water at room temperature to obtain the dispersed phase fluid; disperse In the phase fluid, the mass fraction of polyethylene glycol diacrylate is 50%, the mass fraction of 2-hydroxy-2-methyl-1-phenyl-1-propanone is 5%, and the mass fraction of Pluronic F-127 is 1%.

[0080] Preparation of continuous phase fluid: polyglyceryl ricinoleate was dissolved in soybean oil at room temperature to obtain a continuous phase fluid, and the mass fraction of glyceryl ricinoleate in the continuous phase fluid was 4%.

[0081] Preparation of shear phase fluid: polyglyceryl ricinoleate was dissolved in soybean oil at room temperature to obtai...

Embodiment 2

[0090] In this embodiment, bullet-shaped non-spherical microparticles are prepared, and the steps are as follows:

[0091] (1) Preparation of dispersed phase, continuous phase and shear phase fluid

[0092] Prepare the dispersed phase fluid: Dissolve methacryloyloxyethyl carboxyethyl chitosan, 2-hydroxy-2-methyl-1-phenyl-1-propanone and Pluronic F-127 in deionized Obtain dispersed phase fluid in water; In the dispersed phase fluid, the massfraction of methacryloyloxyethyl carboxyethyl chitosan is 30%, 2-hydroxyl-2-methyl-1-phenyl-1-acetone The mass fraction is 20%, and the mass fraction of Pluronic F-127 is 1%.

[0093] Preparation of continuous phase fluid: polyglyceryl ricinoleate was dissolved in soybean oil at room temperature to obtain a continuous phase fluid, and the mass fraction of glyceryl ricinoleate in the continuous phase fluid was 20%.

[0094] Preparation of shear phase fluid: polyglyceryl ricinoleate was dissolved in soybean oil at room temperature to obtain ...

Embodiment 3

[0103] In this embodiment, bullet-shaped non-spherical microparticles are prepared, and the steps are as follows:

[0104] (1) Preparation of dispersed phase, continuous phase and shear phase fluid

[0105] Prepare the dispersed phase fluid: Dissolve polyethylene glycol diacrylate, 2-hydroxy-2-methyl-1-phenyl-1-propanone, and sodium dodecylsulfonate in deionized water at room temperature to obtain the dispersed phase Fluid; in the dispersed phase fluid, the mass fraction of polyethylene glycol diacrylate is 80%, the mass fraction of 2-hydroxy-2-methyl-1-phenyl-1-propanone is 1%, dodecyl sulfonate The mass fraction of sodium bicarbonate is 20%.

[0106] Preparation of continuous phase fluid: Span80 was dissolved in soybean oil at room temperature to obtain a continuous phase fluid, and the mass fraction of Span80 in the continuous phase fluid was 1%.

[0107] Preparation of shear phase fluid: Span20 was dissolved in soybean oil at room temperature to obtain a shear phase flui...

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Abstract

The invention provides a bullet-shaped non-spherical micro-particle and microcapsule. A matrix of the micro-particle and micro-capsule is a polymerized photopolymerizable macromolecule, and the micro-particle and microcapsule is of an integrated bullet shape and consists of a similarly cone-shaped head portion and a cylindrical tail portion which are smoothly connected with each other; the microcapsule has at least one mutually independent chamber; and an oil phase solution is contained in the chamber. The invention further provides a method for continuously preparing the above bullet-shaped non-spherical micro-particle and microcapsule by using a microfluidic technique. The technical scheme provided by the invention can improve the flow characteristics and the movement rate of the microparticle and microcapsule in a channel, and improve the embedding effect of the microparticle and microcapsule. The microcapsule provided by the invention can realize entrapment and transport of activeingredients such as a drug.

Description

technical field [0001] The invention belongs to the field of preparation of non-spherical polymer microparticles, and relates to a bullet-shaped non-spherical microparticle, a bullet-shaped non-spherical microcapsule, and a preparation method of the bullet-shaped non-spherical microparticle and the microcapsule. Background technique [0002] The shape of microparticles is an important factor affecting their functions and applications. Non-spherical microparticles have a large surface-to-volume ratio, high-efficiency light diffusion, strong scattering, special coalescence behavior and rheological properties, and have shown great promise in many fields. With its unique application potential, it is widely used in the fields of biotechnology, drug carriers, structural materials, cosmetics and medical imaging, and also plays an important role in the basic research of microfluidics and nanotechnology. Compared with spherical microparticles, non-spherical microparticles can effecti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J13/14B01J13/04A61K9/50A61K47/14A61K47/36A61J3/07A61J3/00
CPCA61J3/00A61J3/078A61K9/5031A61K9/5036B01J13/02B01J13/04B01J13/14
Inventor 蔡泉威褚良银巨晓洁陈晨谢锐汪伟刘壮
Owner 四川大川合颐生物科技有限公司
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