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Hydroxylapatite coated collagen-graphene oxide bionic material and preparation method thereof

A hydroxyapatite and collagen technology, which is applied in the field of medicine, can solve the problems of insufficient mechanical strength and easy deformation, and achieves the effects of simple preparation process, low cost and enhanced mechanical properties.

Active Publication Date: 2019-03-12
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, type I collagen has some disadvantages, such as insufficient mechanical strength, easy deformation, etc.

Method used

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  • Hydroxylapatite coated collagen-graphene oxide bionic material and preparation method thereof
  • Hydroxylapatite coated collagen-graphene oxide bionic material and preparation method thereof
  • Hydroxylapatite coated collagen-graphene oxide bionic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] A composite material with a collagen concentration of 1.5% (W / V) and a graphene oxide concentration of 0.15% (W / V) was prepared, and a hydroxyapatite biomimetic coating was prepared on the surface of the material by using the SBF biomimetic mineralization method. Converted into weight percentages, the weight percentage of type I collagen is 22.5%, the weight percentage of graphene oxide is 3%, and the weight percentage of HA is 74.5%.

[0065] Step 1: Preparation of Collagen-Graphene Oxide Composite Material

[0066] (1) Add 30mg type I collagen to 1ml 0.1M acetic acid (0.285ml glacial acetic acid deionized water to 50ml) solution to obtain a 3% (W / V) collagen solution;

[0067] (2) 3 mg of graphene oxide powder was dissolved in 1 ml of 0.1M acetic acid solution under the assistance of ultrasound to obtain a 0.3% (W / V) graphene oxide solution;

[0068] (3) After mixing equal volumes of 3% (W / V) collagen solution and 0.3% (W / V) graphene oxide solution obtained in step (...

Embodiment 2

[0090] A composite material with a collagen concentration of 1.75% (W / V) and a graphene oxide concentration of 0.175% (W / V) was prepared, and a hydroxyapatite biomimetic coating was prepared on the surface of the material by using the SBF biomimetic mineralization method. Converted into weight percentages, the weight percentage of type I collagen is 26.25%, the weight percentage of graphene oxide is 3.5%, and the weight percentage of HA is 70.25%.

[0091] Step 1: Preparation of Collagen-Graphene Oxide Composite Material

[0092] (1) Add 35mg type I collagen to 1ml 0.1M acetic acid (0.285ml glacial acetic acid deionized water to 50ml) solution to obtain a 3.5% (W / V) collagen solution;

[0093] (2) 3.5mg graphene oxide powder was dissolved in 1ml 0.1M acetic acid solution under the assistance of ultrasound to obtain a 0.35% (W / V) graphene oxide solution;

[0094] (3) After mixing equal volumes of 3.5% (W / V) collagen solution and 0.35% (W / V) graphene oxide solution obtained in ...

Embodiment 3

[0115] A composite material with a collagen concentration of 2% (W / V) and a graphene oxide concentration of 2% (W / V) was prepared, and a hydroxyapatite biomimetic coating was prepared on the surface of the material by using the SBF biomimetic mineralization method. Converted into weight percentage, the weight percentage of type I collagen is 30%, the weight percentage of graphene oxide is 4%, and the weight percentage of HA is 66%.

[0116] Step 1: Preparation of Collagen-Graphene Oxide Composite Material

[0117] (1) Add 40mg type I collagen to 1ml 0.1M acetic acid (0.285ml glacial acetic acid deionized water to 50ml) solution to obtain a 4% (W / V) collagen solution;

[0118] (2) Dissolve 4mg of graphene oxide powder in 1ml of 0.1M acetic acid solution under the assistance of ultrasound to obtain a 0.4% (W / V) graphene oxide solution;

[0119] (3) After mixing equal volumes of 4% (W / V) collagen solution and 0.4% (W / V) graphene oxide solution in step (1) and step (2) of this pr...

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Abstract

Disclosed is a hydroxylapatite coated collagen-graphene oxide bionic material. The hydroxylapatite coated collagen-graphene oxide bionic material is composed of, by weight percentage, 22.5-30% of typeI collagen, 3-4% of graphene oxide and 66-74% of hydroxylapatite coating. The preparation of the hydroxylapatite coated collagen-graphene oxide bionic material comprises the steps of (1) preparationof a collagen-graphene oxide material, (2) preparation of simulated body fluid, (3) surface HA (hydroxylapatite) coating of the collagen-graphene oxide material through simulated body fluid mineralization. The hydroxylapatite coated collagen-graphene oxide bionic material is controllable in thickness of HA coating, high in mechanical performance, good in biocompatibility and osteo-conductivity andcapable of achieving good bone repair effects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a bone defect repair material and a preparation method thereof, in particular to a hydroxyapatite (HA)-coated collagen (Col)-graphene oxide (GO) bionic material and a preparation method thereof. Background technique [0002] Large bone defects caused by trauma, infection, tumor, etc. are common clinical problems. Autologous bone grafting is the current standard of care, but there may be disadvantages such as donor site complications, paresthesia, and reduced quality of life. Bone allograft transplantation is another commonly used treatment method, but there may be disadvantages such as infection and immune rejection. Therefore, the implantation of biomaterials can not only avoid the secondary operation caused by autologous bone graft, but also avoid the risk of infection caused by allogeneic bone graft, which is a very promising method. [0003] Bone tissue repair materials should have go...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L27/32A61L27/56
CPCA61L27/32A61L27/443A61L27/56A61L2420/02A61L2430/02C08L89/00
Inventor 周楚超汪振星孙家明吴顺陈雳风李嘉伦周牧冉刘邵恺曾宇阳牟珊黎媛罗超侯金飞方慧敏陈倩文
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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