Preparation method for oxygen-sensitive multifunctional nonometer probe, and product thereof
An oxygen-sensitive, nano-probe technology, applied to medical preparations containing active ingredients, microcapsules, pharmaceutical formulas, etc., can solve problems such as failure to obtain a clear diagnosis and treatment plan, non-created imaging, etc., to meet production and application requirements , simple process and strong operability
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Embodiment 1
[0023] An oxygen-sensitive multifunctional nanoprobe, based on oxygen-sensitive materials, is packaged and modified by biomolecules, and then compounded with photosensitive molecules and fluorocarbons to form an oxygen-sensitive multifunctional nanoprobe, as follows Steps to prepare:
[0024] Add 7.5 parts of 25 mg / mL NH2-PEG solution into the pyrene solution to prevent its agglomeration, and stir at room temperature for 12 hours under nitrogen protection atmosphere to obtain NH2-PEG-pyrene nanoparticles.
[0025] Dissolve 200 parts of 5 mg / mL TR780 in 2 parts of NH2-PEG-pyrene nanoparticles solution, then add 2 parts of pure ethanol and 1 part of FC-4.
[0026] Add 3.67 parts of 25% glutaraldehyde cross-linked NH2-PEG-MnO 2 After 24 hours, deionized water was used to remove impurities to obtain a nanoparticle solution, which was freeze-dried to form a powder. The SEM image of the obtained oxygen-sensitive multifunctional nanoprobe is shown in figure 1 .
Embodiment 2
[0028] An oxygen-sensitive multifunctional nanoprobe, the same as in Example 1, is prepared as follows:
[0029] Add 7.5 parts, 25mg / mL of BSA solution into [Cu(POP)(ptpm)]BF4 solution to prevent its agglomeration, and stir at room temperature under nitrogen protection atmosphere for 12h, to obtain BSA-[Cu(POP)(ptpm)]BF4 nanometer particle.
[0030] Dissolve 200 parts of 5 mg / mL BPD-MA in 4 parts of BSA-[Cu(POP)(ptpm)]BF4 nanoparticles solution, and then add 4 parts of pure ethanol.
[0031] Add 3.67 parts of 25% glutaraldehyde to cross-link the amine group of BSA-[Cu(POP)(ptpm)]BF4, remove impurities with deionized water after 24h to obtain a nanoparticle solution, and lyophilize to form a powder.
Embodiment 3
[0033] An oxygen-sensitive multifunctional nanoprobe, the same as in Example 1, is prepared as follows:
[0034] Add 7.5 parts of 25 mg / mL APTES solution to the coumarin solution to prevent its agglomeration, and stir at room temperature for 12 h under nitrogen protection atmosphere to obtain APTES-coumarin nanoparticles.
[0035] Dissolve 200 parts of 5 mg / mL HPD in 4 parts of APTES-coumarin nanoparticles solution, then add 4 parts of pure ethanol and 4 parts of FC-10.
[0036] Add 3.67 parts of 25% glutaraldehyde to cross-link the amino groups of APTES-coumarin, remove impurities with deionized water after 24 hours to obtain a nanoparticle solution, and freeze-dry to form a powder.
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