Gel containing MG53 protein/MG53 mutant protein, as well as preparation method thereof and application thereof
A technology of protein gel and mutants, which is applied in the medical field to achieve the effects of promoting hyperplasia, shortening the recovery period, and relieving pain
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Embodiment 1
[0053] An MG53 protein / MG53 mutant protein-containing gel comprises the following components: gel matrix, preservatives, antioxidants, and MG53 protein / MG53 mutant protein freeze-dried powder.
[0054] The gel base includes: deionized water, sodium carboxymethyl cellulose, hydroxyethyl cellulose, glycerol acrylate / acrylic acid copolymer, SCLEROTIUM ROLFSSII gum.
[0055] The preservatives include: one or more of ethyl paraben, sodium benzoate, potassium sorbate, methylparaben, and propylparaben. The present invention is preferably: methylparaben and propylparaben. one or both.
[0056] Antioxidants include: EDTA-2Na (disodium ethylenediaminetetraacetate).
[0057] The moisturizing agent includes: one or more of sodium hyaluronate, glycerin, 1,2-pentanediol and butanediol.
[0058] The protein protective agent includes: one or more of glycerol, propylene glycol, human albumin, dextran and trehalose.
[0059] MG53 protein / MG53 mutant protein lyophilized powder includes: MG53 ...
Embodiment 2
[0061] The difference between this embodiment and the above-mentioned embodiment is that a gel containing MG53 protein / MG53 mutant protein has the following formula and ingredients: 55w / w%-66w / w% gel matrix, 3w / w%-5w / w% preservative, 5w / w%-10w / w% antioxidant, 2w / w%-3w / w% humectant, 5w / w%-7w / w% protein protectant, 20w / w%-25w / w% MG53 protein / MG53 mutant protein lyophilized powder.
[0062] The components of the gel matrix include: 45w / w%-50w / w% deionized water, sodium carboxymethylcellulose, 0.2w / w% sodium carboxymethylcellulose, 5w / w%-10w / w % Glycerin, Acrylate / Acrylic Copolymer, Hydrolyzed Sclerotinia Gum
[0063] The components of the preservative include: one or both of 1.5w / w%-3w / w% methylparaben and 1.5w / w%-3w / w% propylparaben.
[0064] The components of the antioxidant include: 5w / w%-10w / w% EDTA-2Na.
[0065] The components of the moisturizing agent include: 0.5w / w%-3w / w% sodium hyaluronate, 0.5w / w%-3w / w% glycerin, 0.5w / w%-3w / w% 1,2-pentanedi One or more of alcohol,...
Embodiment 3
[0070] A preparation method of MG53 protein / MG53 mutant protein gel: comprising the following steps:
[0071] S1. Preparation of gel matrix:
[0072] Add deionized water to the main emulsifying pot, sprinkle hydroxyethyl cellulose powder during stirring, and stir for 10 minutes, then heat to 75°C while stirring until the solution is completely transparent; start to cool down to 45°C, and stir well The components in disodium EDTA, glycerol (and) glycerol acrylate / propylene copolymer (and) propylene glycol sodium hyaluronate are sequentially added to the main emulsification pot to ensure that one component is completely dissolved and then the next component is added; finally a gel is obtained matrix.
[0073] S2. Mix the gel matrix, preservatives, antioxidants, humectants, and protein protectants according to a certain proportion to form a first mixed solution, and sterilize the first mixed solution by autoclaving, and the conditions of autoclaving are: 121° C. ,30 minutes.
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