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Medicine injection for treating anaerobic bacterium infection and preparation method thereof

A technology of injection and anaerobic bacteria, applied in the directions of pharmaceutical formulations, antibacterial drugs, drug delivery, etc., can solve the problems of poor stability of metronidazole glucose injection, and achieve the effects of good dispersibility and good synergy effect.

Inactive Publication Date: 2019-03-08
江西润泽药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a drug injection for the treatment of anaerobic infection and a preparation method thereof in order to overcome the problem of poor stability of the metronidazole glucose injection in the prior art. stability

Method used

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  • Medicine injection for treating anaerobic bacterium infection and preparation method thereof
  • Medicine injection for treating anaerobic bacterium infection and preparation method thereof
  • Medicine injection for treating anaerobic bacterium infection and preparation method thereof

Examples

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preparation example Construction

[0030] The second aspect of the present invention provides a method for preparing a drug injection for treating anaerobic infection, the method comprising the following steps:

[0031] (1) Dissolve metronidazole, citric acid and sodium dihydrogen phosphate in water for injection, then add activated carbon, filter and decarbonize after stirring, to obtain intermediate solution A;

[0032] (2) Dissolve glucose in water for injection, then add activated carbon, filter and decarbonize after stirring, and obtain intermediate solution B;

[0033] (3) Mix the intermediate liquid A and intermediate liquid B, then add disodium hydrogen phosphate to adjust the pH value to 4.5-6.0, add activated carbon and then heat and boil, cool and filter for decarbonization, and pack under sterile conditions potting,

[0034] Wherein, the feeding ratio of metronidazole, glucose, citric acid, sodium dihydrogen phosphate, disodium hydrogen phosphate and water for injection is satisfied, and the obtain...

Embodiment 1

[0049] (1) Add 20L of water for injection into the first concentrated tank, then add 150g of metronidazole (D90≤6.35μm), 30g of citric acid and 60g of sodium dihydrogen phosphate, then add activated carbon, stir for 15min, and use 0.22μm The microporous membrane is decarbonized by filtration to obtain the intermediate solution A;

[0050] (2) Add 20L of water for injection into the second concentrated preparation tank, then add 3750g of glucose, then add activated carbon, stir for 15min, and filter and decarbonize with a 0.22μm microporous membrane to obtain intermediate solution B;

[0051] (3) Mix the intermediate solution A and the intermediate solution B, and transfer to the dilute tank, set the volume to 50L with water for injection, then add 150g of disodium hydrogen phosphate to adjust the pH value to 5.1, then add activated carbon, and stir for 15min. And use a 0.22 μm microporous membrane to filter and decarbonize, and pack and seal under sterile conditions.

Embodiment 2

[0053] (1) Add 20L of water for injection into the first concentrated tank, then add 150g of metronidazole (D90≤6.35μm), 20g of citric acid and 60g of sodium dihydrogen phosphate, then add activated carbon, stir for 15min, and use 0.22μm The microporous membrane is decarbonized by filtration to obtain the intermediate solution A;

[0054] (2) Add 20L of water for injection into the second concentrated preparation tank, then add 3000g of glucose, then add activated carbon, stir for 15min, and filter and decarbonize with a 0.22μm microporous membrane to obtain intermediate solution B;

[0055] (3) Mix the intermediate liquid A and intermediate liquid B, and transfer to the dilute tank, set the volume to 50L with water for injection, then add 150g of disodium hydrogen phosphate to adjust the pH value to 5.5, then add activated carbon, stir for 15min, And use a 0.22 μm microporous membrane to filter and decarbonize, and pack and seal under sterile conditions.

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Abstract

The invention relates to the field of metronidazole medicines and discloses medicine injection for treating anaerobic bacterium infection and a preparation method thereof. The injection is prepared from the following components based on the total weight of the injection: (1) 0.2 to 0.5 weight percent of metronidazole; (2) 4 to 8 weight percent of glucose; (3) 0.01 to 0.08 weight percent of citricacid; (4) 0.05 to 0.3 weight percent of sodium dihydrogen phosphate; (5) 0.1 to 2 weight percent of disodium hydrogen phosphate; (6) 90 to 95 weight percent of injection water. The medicine injectionfor treating the anaerobic bacterium infection, provided by the invention, has good stability.

Description

technical field [0001] The invention relates to the field of metronidazole medicine, in particular to a medicine injection for treating anaerobic infection and a preparation method thereof. Background technique [0002] Metronidazole has a strong antibacterial effect on most anaerobic bacteria, but has no effect on aerobic bacteria and facultative anaerobic bacteria. The antibacterial spectrum includes Bacteroides fragilis and other Bacteroides, Fusobacterium, Clostridium aerogenes Bacillus, Eubacterium, Veillonella, Peptococcus and Peptostreptococcus, etc., Actinomycetes, Lactobacillus, and Propionibacterium are resistant to this product. [0003] Metronidazole glucose injection is mainly used for the treatment of anaerobic infection, but in the prior art, metronidazole glucose injection only contains metronidazole and glucose, without adding other excipients, the stability of the injection needs to be improved . Contents of the invention [0004] The purpose of the pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4164A61K47/02A61K47/12A61K47/26A61P31/04
CPCA61K9/0019A61K9/08A61K31/4164A61K47/02A61K47/12A61K47/26A61P31/04
Inventor 廖年生邹明明胡贤德眭荣春
Owner 江西润泽药业有限公司
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