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Polypeptide freeze-drying composition with skin activity and preparation method thereof

A composition and active technology, applied in the field of polypeptide freeze-dried composition with skin activity and preparation thereof, can solve the problems of few freeze-drying technology, high production cost, high energy consumption of freeze-drying process and the like

Pending Publication Date: 2019-03-08
宇肽生物(东莞)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the traditional cosmetics industry, the application of freeze-drying technology is relatively small, which does not match the rapid development of the industry. This has a lot to do with the high energy consumption and high production cost of the freeze-drying process.

Method used

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  • Polypeptide freeze-drying composition with skin activity and preparation method thereof
  • Polypeptide freeze-drying composition with skin activity and preparation method thereof
  • Polypeptide freeze-drying composition with skin activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Preparation method of polypeptide freeze-dried composition with anti-wrinkle and anti-aging effects

[0066] prescription

[0067]

[0068] Preparation:

[0069] 1. Accurately weigh mannitol, trehalose, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase A, add to the prescribed amount of water for injection, manually stir for 5-10 minutes until the solution is clear and transparent, and set aside;

[0070] 2. Accurately weigh each peptide powder and Tween 20 in phase B, add warm water (20°C-35°C), stir manually while ultrasonicating for 5-10min, until the liquid in phase B is clear and transparent, set aside;

[0071] 3. Keep stirring phase A, add phase B to phase A, and continue stirring for 3-5 minutes until the solution is clear and transparent;

[0072] 4. Use a 0.22 μm filter to sterilize and filter the solution in step 3 to obtain a semi-finished product;

[0073] 5, the qualified semi-finished product is filled, according to the...

Embodiment 2

[0074] Example 2 Preparation method of polypeptide freeze-dried composition with whitening and freckle-removing effects

[0075] prescription

[0076]

[0077] Preparation:

[0078] 1. Accurately weigh mannitol, trehalose, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase A, add to the prescribed amount of water for injection, manually stir for 5-10 minutes until the solution is clear and transparent, and set aside;

[0079] 2. Accurately weigh each peptide powder and Tween 20 in phase B, add warm water (20°C-35°C), stir manually while ultrasonicating for 5-10min, until the liquid in phase B is clear and transparent, set aside;

[0080] 3. Keep stirring phase A, add phase B to phase A, and continue stirring for 3-5 minutes until the solution is clear and transparent;

[0081] 4. Use a 0.22 μm filter to sterilize and filter the solution in step 3 to obtain a semi-finished product;

[0082] 5, the qualified semi-finished product is filled, according to ...

Embodiment 3

[0083] Example 3 Preparation method of polypeptide freeze-dried composition with soothing and antisensitivity effects

[0084] prescription

[0085]

[0086] Preparation:

[0087] 1. Accurately weigh mannitol, trehalose, disodium hydrogen phosphate, and sodium dihydrogen phosphate in phase A, add to the prescribed amount of water for injection, manually stir for 5-10 minutes until the solution is clear and transparent, and set aside;

[0088] 2. Accurately weigh each peptide powder and Tween 20 in phase B, add warm water (20°C-35°C), stir manually while ultrasonicating for 5-10min, until the liquid in phase B is clear and transparent, set aside;

[0089] 3. Keep stirring phase A, add phase B to phase A, and continue stirring for 3-5 minutes until the solution is clear and transparent;

[0090] 4. Use a 0.22 μm filter to sterilize and filter the solution in step 3 to obtain a semi-finished product;

[0091] 5, the qualified semi-finished product is filled, according to th...

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Abstract

The invention discloses a polypeptide freeze-drying composition with skin activity and a preparation method thereof and belongs to the technical field of beauty polypeptide. The composition is prepared from polypeptide with skin activity, an excipient, a solubilizer and a pH buffer agent. The preparation method of the composition disclosed by the invention comprises the following steps: dissolving, mixing, filtering, sterilizing and filling all the ingredients; setting freeze drying according to a freeze-dry curve to obtain the polypeptide freeze-drying composition with the skin activity. Thepreparation method has the advantages of simple operation and mature and controllable technologies; furthermore, freeze drying is finished within 18h, so that the product quality is ensured; simultaneously, the production energy consumption is reduced, and the production cost is reduced. The polypeptide freeze-drying composition with skin activity prepared by the method has the advantages of goodstability, easiness in storage and no preservative addition. The composition disclosed by the invention is mainly applied to removing wrinkles, resisting senility, whitening the skin, removing freckles, relieving and resisting allergy, removing eye bags, developing hair and fixing hair, so that varieties of skin problems can be improved.

Description

technical field [0001] The invention belongs to the technical field of cosmetic polypeptides, and provides a skin-active polypeptide freeze-dried composition and a preparation method thereof. Background technique [0002] Polypeptides are compounds formed by linking amino acids through peptide bonds, and play an important regulatory role in various physiological activities in the body. Since the polypeptide is homologous to the body substances, it is non-toxic and non-irritating to the human body. It also has a variety of biological activities, is easy to be absorbed through the skin, and can significantly improve various skin problems, so it has attracted extensive attention from the beauty and health care industry. [0003] At present, the peptides used in the beauty and cosmetics market are mainly in the form of liquids. However, peptides are not stable in solution and are easily hydrolyzed and oxidized. Therefore, products in liquid form are not conducive to the use of p...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61Q19/08A61Q19/02A61Q19/00A61Q7/00
CPCA61K8/64A61K2800/30A61K2800/5922A61K2800/84A61Q7/00A61Q19/00A61Q19/005A61Q19/02A61Q19/08
Inventor 丁文锋
Owner 宇肽生物(东莞)有限公司
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