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Preparation method of solid proliposome with acne removing efficacy

A proliposome, acne-removing technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations and other directions, can solve the problems of high irritation, affecting the use effect, unpleasant smell and the like

Inactive Publication Date: 2019-02-12
PROYA COSMETICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, after acne is removed, it is easy to leave pigmentation on the skin, that is, acne marks, which seriously affects the appearance of people. Therefore, cosmetics with anti-acne effects have attracted more and more attention from consumers.
[0003] The anti-acne active ingredients used in cosmetics, such as salicylic acid, are highly irritating and easy to precipitate due to low solubility; such as matrine, which is easy to change color under high temperature light and has an unpleasant smell; most of these anti-acne active ingredients are currently encapsulated by traditional liposomes. However, there are disadvantages such as easy aggregation and fusion, easy oxidation and hydrolysis of phospholipids, easy leakage of encapsulated active ingredients, and low content of active ingredients, which affect the use effect

Method used

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  • Preparation method of solid proliposome with acne removing efficacy
  • Preparation method of solid proliposome with acne removing efficacy
  • Preparation method of solid proliposome with acne removing efficacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A method for preparing a solid proliposome with anti-acne effect, characterized in that the following steps are adopted:

[0053] A. Weigh raw materials according to the following mass percentages: 10.0% anti-acne composition, 4.5% compound emulsifier, 12.0% ethanol (95% volume fraction), 2.0% isododecane, 0.5% sponge microneedle, 4.0% mannose Alcohol, residual distilled water; the acne-removing composition is composed of vitamin B6, heparin sodium, glucosyl hesperidin, Nocardia rubra cell wall skeleton with a mass ratio of 3.0: 8.0: 5.0: 1.0: 4.5: 6.0: 2.5 , retinol, chlorogenic acid, dihydroquercetin; the composite emulsifier is composed of hydrogenated lecithin, sodium cocoyl monoglyceride sulfate, dicetyl phosphoric acid with a mass ratio of 4.0:0.2:1.5 Ester composition;

[0054] B. Put the compound emulsifier and distilled water weighed in step A into an emulsification pot with a bottom stirrer, heat to 75°C, and stir at a speed of 250rpm until completely dissolv...

Embodiment 2

[0060] A method for preparing a solid proliposome with anti-acne effect, characterized in that the following steps are adopted:

[0061] A. Weigh raw materials according to the following mass percentages: 5.0% anti-acne composition, 3.0% compound emulsifier, 8.0% ethanol (95% volume fraction), 1.0% isododecane, 1.0% sponge microneedle, 6.0% mannose Alcohol, residual distilled water; the acne-removing composition is composed of vitamin B6, heparin sodium, glucosyl hesperidin, Nocardia rubra cell wall skeleton with a mass ratio of 5.0: 6.0: 6.0: 2.0: 3.0: 4.0: 1.0 , retinol, chlorogenic acid, dihydroquercetin; the compound emulsifier is composed of hydrogenated lecithin, sodium cocoyl monoglyceride sulfate, dicetyl phosphoric acid with a mass ratio of 2.5: 0.3: 1.0 Ester composition;

[0062] B. Put the compound emulsifier and distilled water weighed in step A into an emulsification pot with a bottom stirrer, heat to 78°C, and stir at a speed of 200rpm until completely dissolve...

Embodiment 3

[0068] A method for preparing a solid proliposome with anti-acne effect, characterized in that the following steps are adopted:

[0069] A. Weigh raw materials according to the following mass percentages: 11.0% anti-acne composition, 5.0% compound emulsifier, 12.0% ethanol (95% volume fraction), 3.5% isododecane, 0.8% sponge microneedle, 7.5% mannose Alcohol, residual distilled water; the acne-removing composition is composed of vitamin B6, heparin sodium, glucosyl hesperidin, Nocardia rubra cell wall skeleton with a mass ratio of 4.0: 5.0: 4.5: 3.0: 3.5: 7.0: 1.8 , retinol, chlorogenic acid, dihydroquercetin; the composite emulsifier is composed of hydrogenated lecithin, sodium cocoyl monoglyceride sulfate, dicetyl phosphoric acid with a mass ratio of 3.0:0.1:2.0 Ester composition;

[0070] B. Put the compound emulsifier and distilled water weighed in step A into an emulsification pot with a bottom stirrer, heat to 80°C, and stir at a speed of 300rpm until completely dissolv...

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Abstract

The invention relates to a preparation method of solid proliposome with acne removing efficacy. The method is characterized by adopting the following steps that 1, an acne removing compound, a compound emulsifier, ethyl alcohol, isododecane, sponge spicules, mannitol and the balance distilled water are weighed according to a mass ratio, wherein the acne removing compound is prepared from vitamin B6, heparin sodium, glucosyl hesperidin, nocardia rubra cell wall skeletons, retinol, chlorogenic acid and dihydroquercetin with a specific mass ratio; 2, the compound emulsifier and the distilled water are added into an emulsifying pot, and an alcohol-soluble acne-removing active component is added into the emulsifying pot after being dissolved in the ethyl alcohol; 3, the retinol and the isododecane are mixed to obtain a liquid oil phase; 4, the liquid oil phase is added into the emulsifying pot, a mixture is stirred evenly to obtain a premixed solution, and then high-pressure homogenizing isconducted to obtain liquid lipidosome; 5, the sponge spicules and the mannitol are added into the liquid lipidosome, and vacuum freeze drying is conducted to obtain the solid proliposome with the acne removing efficacy.

Description

technical field [0001] The invention relates to the technical field of liposome preparation, in particular to a method for preparing solid proliposomes with acne-removing effects. Background technique [0002] Acne is a chronic inflammation of the pilosebaceous glands. The main causes are: 1. Endocrine disorders, strong secretion of male hormones, active sebum secretion that cannot be discharged in time, and fat plugs are formed in hair follicles; 2. Acne bacillus hyperplasia , the lipolytic enzyme produced can decompose sebum into free fatty acid, which will destroy the hair follicle wall, stimulate the dermis and surrounding tissues, and cause inflammation around the pilosebaceous gland; over. In addition, after acne is removed, pigmentation is easily left on the skin, that is, acne marks, which seriously affects people's appearance. Therefore, cosmetics with anti-acne effects are more and more concerned by consumers. [0003] The anti-acne active ingredients used in cos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/99A61K8/14A61K8/37A61K8/49A61K8/60A61K8/67A61K8/73A61P17/10A61Q19/00
CPCA61K8/14A61K8/375A61K8/498A61K8/602A61K8/671A61K8/673A61K8/735A61K8/99A61Q19/00A61P17/10
Inventor 薛绘杨盼盼蒋丽刚李欣航吕旭阳李昊王晗宁
Owner PROYA COSMETICS
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