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A blood lead removal instrument for removing blood lead in vitro

A technology of blood and blood lead, which is applied in the field of biomedical instruments, can solve problems such as inability to enter red blood cell lead ions, impossibility and poor removal of lead ions, and severe blood lead poisoning, so as to overcome unclear removal principles, relieve illness, compose simple effects

Active Publication Date: 2020-10-16
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, more than 95% of blood lead ions are located in red blood cells and combined with hemoglobin, which causes a major difficulty in blood lead removal
At present, the clinical treatment of blood lead poisoning can be divided into taking lead-dispelling drugs and hemoperfusion; the treatment of mild blood lead poisoning is taking small-molecule lead-dispelling drugs such as edetate disodium calcium, dimercaptopropanol, Mercaptosuccinic acid has a long treatment cycle (40-60 days), large side effects and poor therapeutic effect; the treatment method for severe blood lead poisoning is hemoperfusion, which is to use a hemoperfusion device containing resin or activated carbon with adsorption function to hemoperfusion. Cleaning, adsorption of toxic substances in serum
Since the adsorbent in the hemoperfusion device has a large size and is fixed inside the perfusion device, it cannot enter the red blood cells to remove the lead ions in the red blood cells. Therefore, hemoperfusion generally removes toxic substances in the serum, and it is almost impossible to remove the lead ions in the red blood cells. Finish

Method used

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  • A blood lead removal instrument for removing blood lead in vitro
  • A blood lead removal instrument for removing blood lead in vitro
  • A blood lead removal instrument for removing blood lead in vitro

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1) Preparation of magnetic ferroferric oxide (Fe 3 o 4 NPs)

[0043] Weigh ferric chloride hexahydrate (1.35g, 5mmol) and fully dissolve it in 30mL of ethylene glycol solution. Sodium acetate (NaAc, 3.6 g) and polyethylene glycol-2000 (PEG-2000 1.0 g) were added with stirring. Stirring was continued for 30 min, and the solution was transferred to a high-temperature reactor at 200° C. for 72 h. After natural cooling, it was washed with deionized water and ethanol solution several times in sequence, and dried under vacuum at 60°C.

[0044] 2) Preparation of magnetic Fe3O4 / aminated mesoporous silica composites using polylysine as template (MMS / P NPs)

[0045] Dissolve 100 mg sodium lauroyl sarcosinate into 10 mL citric acid / sodium citrate buffer solution (0.1 M, pH 5.2) at room temperature, and add 150 μL ε-polylysine (20 wt %) to the solution. At this point, the solution immediately becomes an emulsion, generating polylysine / sodium lauroyl sarcosinate composite micel...

Embodiment 2

[0055] 1) Preparation of magnetic ferric oxide

[0056] Synthesis of ferric oxide nanoparticles (FeO) by hydrothermal method 3 o 4 NPs). The specific method is as follows: Weigh ferric trichloride hexahydrate (1.35 g, 5 mmol), and fully dissolve it in 40 mL of ethylene glycol solution. Sodium acetate (NaAc, 1.8 g) and sodium citrate trihydrate (Na 3 Cit 0.2g). Stirring was continued for 1 h, and the solution was transferred to a high-temperature reactor at 200° C. for 20 h. After natural cooling, it was washed with deionized water and ethanol solution several times in sequence, and dried under vacuum at 60°C.

[0057] 2) Preparation of magnetic Fe3O4 / rich aminated mesoporous silica composites (MMS / H NPs) using hyperbranched polyamide (PAMAM) as template

[0058] Will Fe 3 o 4 NPs solution (3mg / mL, 50mL) was mixed evenly with 9mL hydrazine hydrate, and treated with ultrasound for 30min. The mixture was transferred to a three-neck flask, and 70 mL of deionized water was...

Embodiment 3

[0064] 1) Preparation of magnetic ferric oxide

[0065] Synthesis of ferric oxide nanoparticles (FeO) by hydrothermal method 3 o 4 NPs). The specific method is as follows: Weigh ferric trichloride hexahydrate (1.35 g, 5 mmol), and fully dissolve it in 40 mL of ethylene glycol solution. Sodium acetate (NaAc, 1.8 g) and sodium citrate trihydrate (Na 3 Cit 0.2g). Stirring was continued for 1 h, and the solution was transferred to a high-temperature reactor at 200° C. for 20 h. After natural cooling, it was washed with deionized water and ethanol solution several times in sequence, and dried under vacuum at 60°C.

[0066] 2) Preparation of magnetic Fe3O4 / rich aminated mesoporous silica composites using chitosan as template

[0067] Will Fe 3 o 4 NPs solution (3mg / mL, 50mL) was mixed evenly with 9mL hydrazine hydrate, and treated with ultrasound for 30min. The mixture was transferred to a three-neck flask, and 70 mL of deionized water was added. Then 90 mg TEOS was added,...

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Abstract

A blood lead remover for removing blood lead in vitro. The blood lead remover comprises: an extracorporeal circulation unit (1), an adsorbent sample feeding device (2), a contact device (3), and a magnetic separation device which are sequentially connected; an adsorbent is loaded in the adsorbent sample feeding device (2), and the composition of the adsorbent is a magnetic ferroferric oxide / rich-aminated mesoporous silica composite material which takes an amine-rich organic matter as a template agent and has a regular mesoporous channel. Compared with an oral medication, use of the blood lead remover can directly remove lead ions in the blood in a short time by means of extracorporeal blood circulation, quickly alleviate the condition of a patient suffering from blood lead poisoning, and reduce side effects caused by daily medications. The blood lead remover has the beneficial effects that the structure is simple, the use is convenient, and a working position can be flexibly changed, thereby solving the problem that a blood perfusion device cannot remove lead ions in red blood cells in the blood, improving working efficiency, being suitable for wide application, and having a wide application prospect in the medical field.

Description

technical field [0001] The invention belongs to biomedical instruments, in particular to a blood lead purifying instrument for removing blood lead in vitro. Background technique [0002] Human health is greatly threatened by exposure to lead ions, which can cause serious toxic effects and diseases (such as heart disease and kidney disease, etc.). When lead ion enters human body, it is mainly deposited in bone, soft tissue and blood. Based on today's biomedical level, it is difficult to remove lead ions deposited in human bones and soft tissues. Therefore, it is of great significance to remove trace amounts of lead ions (blood lead) in blood. However, more than 95% of blood lead ions are located in red blood cells and combined with hemoglobin, which causes a major difficulty in blood lead removal. At present, the clinical treatment of blood lead poisoning can be divided into taking lead-dispelling drugs and hemoperfusion; the treatment of mild blood lead poisoning is takin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36B01J20/10B01J20/28B01J20/30
CPCA61M1/3679B01J20/103B01J20/28009B01J20/3057
Inventor 毛春万密密沈健陈焕王琪初美琳牛倩朱天宇
Owner NANJING NORMAL UNIVERSITY
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