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Red algae oligosaccharide and preparation method and application thereof

A technology of oligosaccharides and red algae polysaccharides, which is applied in the direction of allergic diseases and drug combinations, can solve the problems of strict equipment requirements, difficulty in finding degrading enzymes, low molecular weight, etc., and achieve simple equipment and process, strong anti-allergic effect, Easy to produce applied effects

Active Publication Date: 2019-01-04
广东英贝健生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The biodegradation method mainly uses enzymes to degrade, such as the method for degrading Enteromorpha polysaccharides reported in Chinese patent CN103951761, but this method has certain disadvantages: it is difficult to find a suitable degrading enzyme for a specific polysaccharide, and the cost is relatively high. Harsh, still in the laboratory stage
[0004] In order to solve the shortcomings of red algae polysaccharide degradation method, such as high cost, strict equipment requirements, degradation product activity attenuation, and unsuitable for production and application, the method of pressure treatment combined with vitamin C compounding is used to degrade red algae polysaccharide, which can obtain low molecular weight, easy production and application, and Red algae oligosaccharides with anti-allergic effect

Method used

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  • Red algae oligosaccharide and preparation method and application thereof
  • Red algae oligosaccharide and preparation method and application thereof
  • Red algae oligosaccharide and preparation method and application thereof

Examples

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Embodiment 1

[0019] Example 1 The preparation of Porphyra oligosaccharides and the antiallergic activity of its degradation products include the following steps.

[0020] (1) Preparation of Porphyra oligosaccharides: Add 1 g of Porphyra polysaccharide with an average weight molecular weight of 2428.81kDa to 200mL of ultrapure water to fully dissolve it, and use an autoclave device to treat the polysaccharide solution, controlling the temperature at 127°C and pressure React under the condition of 0.13MPa for 5h, after cooling, add vitamin C to make the final concentration 30mM, react at room temperature for 30min, add 4 times the volume of absolute ethanol, and precipitate through freeze-drying to obtain low molecular weight Porphyra oligosaccharides ( figure 1 ), undegraded Porphyra laver polysaccharides are lumpy and poorly soluble; the product degraded by pressure and vitamin C is powdery and has good solubility.

[0021] (2) Physicochemical properties of Porphyra oligosaccharides: Deter...

Embodiment 2

[0033] Example 2 The preparation of asparagus oligosaccharides and its antiallergic activity comprises the following steps.

[0034] (1) Preparation of asparagus oligosaccharides: add 1 g of asparagus polysaccharides with an average weight molecular weight of 152.48 kDa to 200 mL of ultrapure water to fully dissolve it, and use an autoclave device to treat the polysaccharide solution, and control the temperature at 127 ℃, and a pressure of 0.13 MPa for 3 hours, add vitamin C with a final concentration of 30 mM and react at room temperature for 30 minutes, add 4 times the volume of absolute ethanol, precipitate and freeze-dry to obtain asparagus oligosaccharides. Finished form such as figure 1 , the non-degraded asparagus polysaccharides are lumpy and have poor solubility; the asparagus oligosaccharides degraded by pressure and vitamin C are powdery and have good solubility.

[0035] (2) Physicochemical property detection of asparagus oligosaccharides: with reference to the de...

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Abstract

The invention discloses red algae oligosaccharide and a preparation method and application thereof and relates to red algae polysaccharide. Red algae oligosaccharide is red algae polysaccharide of 2-150kDa in molecular weight and is powdery. The preparation method includes: preparing red algae polysaccharide into a polysaccharide solution, cooling after reaction, adding vitamin C for reaction, removing residual vitamin C, adding anhydrous alcohol for precipitating, and drying to obtain red algae oligosaccharide. Red algae oligosaccharide can be applied in preparing antiallergic drug. Accordingto production needs, powdery red algae oligosaccharide can be obtained by utilizing pressure and vitamin C to compositely degrade red algae polysaccharide, and molecular weight is 2-150kDa. Red algaeoligosaccharide obtained by degradation through the method is low in viscosity, high in solubility and strong in antiallergic effect. The preparation method has the advantages of simple equipment andprocess, low cost and easiness in production and application.

Description

technical field [0001] The invention relates to red algae polysaccharides, in particular to a red algae oligosaccharide (Porphyra oligosaccharide, asparagus oligosaccharide), a preparation method and application thereof. Background technique [0002] Red algae polysaccharides are extracted from red algae, and most of them are sulfate-rich polysaccharides. At present, carrageenan and agar gum are widely used. Red algae polysaccharide has immune regulation function, anti-virus effect, anti-tumor effect, anti-cardiovascular disease, anti-oxidation activity, anti-radiation effect, anti-mutation effect, etc. It is a new type of high-efficiency green nutrition (Hu Tingting. Activity Research Progress [J]. Science and Technology Vision, 2012(36): 17). Since my country's red algae resources are very rich, it has great development prospects. Although it has been proven to have certain biological functional activities, its application in the food industry, health care products, medi...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61P37/08
CPCA61P37/08C08B37/00C08B37/0003
Inventor 刘光明张亚芬刘庆梅刘红刘波韩晶
Owner 广东英贝健生物科技有限公司
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