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Aqueous iron carbonyl compound as well as preparation method and application thereof

A compound, iron carbonyl technology, applied in the field of water-soluble iron carbonyl compounds and their preparation, can solve problems such as water solubility and poor stability, and achieve good biocompatibility, good stability, and good stability effects

Active Publication Date: 2019-01-04
JIAXING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the CO release agents currently on the market have poor water solubility and stability, so it is urgent to develop a CO release agent with good water solubility and stability.

Method used

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  • Aqueous iron carbonyl compound as well as preparation method and application thereof
  • Aqueous iron carbonyl compound as well as preparation method and application thereof
  • Aqueous iron carbonyl compound as well as preparation method and application thereof

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Experimental program
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Embodiment Construction

[0032] The present invention will be further described in detail below in conjunction with the accompanying drawings, so that those skilled in the art can implement it with reference to the description.

[0033] 1. Preparation of compounds

[0034] Such as figure 1 As described, in 30mL methanol (CH 3 OH) by adding 303mg CpFe(CO) 2 1, add 154.30mg mercaptoethylamine in 2mL deionized water, add the aqueous solution dropwise in the methanol solution, react at room temperature for 5h, obtain a red solution, remove the solvent (methanol and deionized water) therein by rotary evaporation, and then use a silica gel column For separation, the eluent is ethyl acetate:methanol=1:1. Finally, a pure red oily substance was obtained, tentatively named compound Fe 1

[0035]

[0036] Such as figure 2 As described, in 30mL methanol (CH 3 OH) by adding 303mg CpFe(CO) 2 I, add 326.38mg tiopronin and 250μL triethylamine (NEt) in 2mL deionized water 3 ), the aqueous solution was add...

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PUM

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Abstract

The invention discloses an aqueous iron carbonyl compound, which has a structural formula shown in the description. According to the invention, the compound has good water solubility and moderate stability, according to the structural formula of the compound, the degradation product of the compound has good biocompatibility and has no harm or less toxicity to organisms, and the timing for releasing carbon monoxide is controllable. Meanwhile, the synthesis method of the compound has universality, and the compound containing glycerol (HS-R) can be reacted with iodo-half-metallocene iron under aalkaline condition to obtain a dicarbonyl half-metallocene iron compound similar to a structure of [CpFe (CO) 2(SR) ] .

Description

technical field [0001] The invention relates to the field of iron carbonyl compounds. More specifically, the present invention relates to a water-soluble iron carbonyl compound and its preparation method and application. Background technique [0002] Carbon monoxide (CO) is a well-known toxic gas, often referred to as the "silent killer". CO can enter the human body through the lungs through breathing, and combine with hemoglobin in the blood to form carboxyhemoglobin. Because its binding force to hemoglobin is much higher than that of oxygen to hemoglobin (about 230 times), it inhibits the transport of oxygen into red blood cells, and the oxygen produced by the tissue is insufficient, which will eventually lead to the death of the body. It can be seen that direct inhalation of CO gas is Very dangerous: At the same time, a small amount of carbon monoxide is very important to the human body. Studies have shown that CO is an important messenger molecule in the body and parti...

Claims

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Application Information

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IPC IPC(8): C07F17/02C01B32/40
CPCC07F17/02C01B32/40
Inventor 刘小明顾二形姜秀娟肖志音
Owner JIAXING UNIV
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