3D printed PCL-Li bone tissue engineering scaffold, and preparation method thereof

Abstract

The invention discloses a 3D printed PCL-Li bone tissue engineering scaffold, and a preparation method thereof. According to the preparation method, epsilon-caprolactone PCL and lithium chloride are taken as raw materials of the 3D printed PCL-Li bone tissue engineering scaffold, 3D printing technology is adopted to prepare the 3D printed PCL-Li bone tissue engineering scaffold. After of implantation of the 3D printed PCL-Li bone tissue engineering scaffold into human body, PCL is degraded gradually as a biologically absorbable material, Li is released to promote osteochondral osteogenesis; and in addition, a porous structure of the 3D printed PCL-Li bone tissue engineering scaffold is capable of inducing bone ingrowth, and repairing of bone defects caused by bone wound, tumor, and infection can be realized. The 3D printed PCL-Li bone tissue engineering scaffold is simple and reliable in structure; the appearance and the microstructure are controllable; the mechanical properties are reliable; ion release properties are controllable; implantation is convenient; wound is small; and cost is low.

Description

technical field [0001] The invention belongs to the field of bone tissue repair and reconstruction, and relates to a 3D printed PCL-Li bone tissue engineering support and a preparation method thereof. Background technique [0002] Clinically, bone defects caused by trauma, tumors, and infections are very common. Every year, a large number of patients with bone tissue defects in my country need surgical treatment. Finding bone tissue engineering repair materials with good biological properties has always been a hot spot in orthopedic research. How to find more and better bone tissue regeneration repair materials to repair human life and recreate health has become the common pursuit and tireless pursuit of many scientists around the world. research impetus. [0003] Although there are many treatments for bone defect repair, these methods generally have many problems such as few sources, many complications, immune rejection and iatrogenic infection, especially for the treatmen...

AI Technical Summary

Problems solved by technology

Including: 1. Autologous bone transplantation, which is limited by the limitation of its own donors and cannot be used repeatedly in large quantities; 2. Allogeneic bone transplantation, which mainly has problems such as immune rejection, pathogen transmission, and high cost; 3. Various Artificial bone substitute materials made of metals, ceramics or polymers have been used clinically, but most of them are used as permanent implants. They cannot participate in the metabolism of the human body, so the long-term effect is often unsatisfactory

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