Preparation method of up-conversion nanometer hybrid system based on heterogeneous growth of nanometer palladium, preparation method and applications thereof

A nano-palladium and rare earth up-conversion technology, applied in preparations for in vivo tests, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor water solubility and poor consistency, Achieve the effect of stable quality, good consistency and good uniformity

Active Publication Date: 2018-11-30
SHANGHAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims at the deficiencies of the prior art, and provides a kind of up-conversion nano-hybrid system based on nano-palladium heterogeneous growth, preparation method and application using the seed growth method, so as to overcome the poor stability and consistency of its components And poor water solubility, biocompatibility, etc., expand the application field; at the same time simplify its preparation steps, reduce the preparation cost, easy to industrialize, and finally realize the integration of fluorescence imaging, magnetic resonance imaging, and photothermal therapy, so that the material and preparation process, Can meet the needs of clinical diagnosis and treatment integration for cancer and other diseases

Method used

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  • Preparation method of up-conversion nanometer hybrid system based on heterogeneous growth of nanometer palladium, preparation method and applications thereof
  • Preparation method of up-conversion nanometer hybrid system based on heterogeneous growth of nanometer palladium, preparation method and applications thereof
  • Preparation method of up-conversion nanometer hybrid system based on heterogeneous growth of nanometer palladium, preparation method and applications thereof

Examples

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Embodiment 1

[0031] See attached Figure 1~4 , the preparation method of a rare earth erbium-doped up-conversion nano-hybrid system based on nano-palladium heterogeneous growth provided in this embodiment, the core is to use the seed growth method to grow nano-palladium-modified rare-earth erbium-doped up-conversion The method for preparing converted luminescent nanoparticles comprises the following steps:

[0032] 1) Coat the surface with a layer of inert NaGdF 4The mixed solution of the oil-soluble rare earth up-conversion luminescent nanoparticles and deionized water is adjusted to be acidic with dilute hydrochloric acid, and mixed and stirred to obtain the first dispersion liquid;

[0033] Specifically: prepare a certain volume of deionized water and adjust the pH to 2-4 with a small amount of dilute hydrochloric acid solution, and then coat the surface dispersed in cyclohexane with a layer of inert NaGdF at a ratio of 4.5:3-1.5:1 4 The oil-soluble rare earth up-conversion nanopartic...

Embodiment 2

[0052] This embodiment provides a rare earth thulium-doped upconversion nano-hybrid system based on heterogeneous growth of nano-palladium, a preparation method and its application, which are basically the same as in Example 1, except that it includes the following steps:

[0053] (1) Prepare 8 mL of deionized water and adjust the pH to 2-4 with a small amount of dilute hydrochloric acid solution, and prepare 4 mL of oil-soluble NaYF dispersed in cyclohexane with a particle size of 28-35 nm. 4 :Yb,Tm@NaGdF 4 Add it, and react at room temperature for 5 hours to remove the oleic acid ligand, centrifuge and wash to obtain the first dispersion.

[0054] (2) First dissolve 0.4g of cetyltrimethylammonium chloride (CTAB) ultrasonically in 300mL of plasma water, then dissolve 44mg of palladium chloride in 22mL of 0.02mol / L dilute hydrochloric acid, and heat at 40°C Stir under low temperature to fully dissolve, cool to room temperature, then mix with cetyltrimethylammonium chloride (C...

Embodiment 3

[0057] This embodiment provides a rare earth erbium and thulium co-doped upconversion nano-hybrid system based on nano-palladium heterogeneous growth, a preparation method and its application, which are basically the same as those in Examples 1 and 2, except that It includes the following steps:

[0058] (1) Prepare 12 mL of deionized water and adjust the pH to 2-4 with a small amount of dilute hydrochloric acid solution, and prepare 6 mL of oil-soluble NaYF dispersed in cyclohexane with a particle size of 28-35 nm. 4 :Yb,Er,Tm@NaGdF 4 Add it, and react at room temperature for 6h to remove the oleic acid ligand, centrifuge and wash to obtain the first dispersion.

[0059] (2) First, ultrasonically dissolve 0.6g of cetyltrimethylammonium chloride (CTAB) in 340mL of plasma water, then dissolve 44.5mg of palladium chloride in 23mL of 0.02mol / L dilute hydrochloric acid, and heat at 40°C Stir under the conditions to fully dissolve, cool to room temperature, then mix with cetyltri...

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Abstract

The invention discloses a preparation method of an up-conversion nanometer hybrid system based on heterogeneous growth of nanometer palladium. According to the method, nanometer palladium is subjectedto heterogeneous nucleation growth on the surface of rare earth up-conversion luminescent nanoparticles to form the nanometer hybrid system; the surface of the rare earth up-conversion luminescent nanoparticles is coated with a layer of inert NaGdF4; the surface of the formed nanometer hybrid system is further modified with an organic ligand so as achieve good water solubility; and the final nanometer hybrid system is used for bimodal imaging diagnostic guided photothermal therapy. According to the present invention, the preparation method has advantages of simple process and high efficiency;and the nanometer hybrid system has advantages of good stability and good biocompatibility, has the photothermal conversion efficiency of 80-90%, is used for up-conversion fluorescence imaging and magnetic resonance imaging, can be used as the high conversion efficiency photothermal agent for photothermal therapy, and can meet the clinical diagnosis and treatment integration requirements.

Description

technical field [0001] The invention relates to the technical field of manufacturing nano-biological materials, in particular to an up-conversion nano-hybrid system based on nano-palladium heterogeneous growth, a preparation method and an application. Background technique [0002] For a long time, cancer is still one of the important causes of human death. Currently, chemotherapy and radiotherapy are the main methods used in the clinical treatment of tumors. However, these two treatment methods have certain shortcomings. Chemotherapy will produce drug resistance, and radiotherapy has large side effects, and neither can achieve the effect of completely treating tumors. Photothermal therapy is a non-invasive treatment technology, which can increase the local temperature in tumors by laser irradiation and lead to the ablation of cancer cells. Various nanomaterials as photothermal therapy drugs have aroused widespread interest. [0003] In recent years, fluorescence imaging has...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K49/00A61K49/18A61P35/00A61K47/58A61K47/60A61K47/69
CPCA61K41/0052A61K49/0002A61K49/0054A61K49/0093A61K49/1854A61K49/186A61K47/58A61K47/60A61K47/6929A61P35/00
Inventor 孙丽宁施利毅赵慧君赵磊汪姝含王卓
Owner SHANGHAI UNIV
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