Preparation method of tablet containing grease components at high dosage

A high-dose, oil-ester technology, applied in the directions of medical preparations containing active ingredients, medical preparations without active ingredients, and plant/algae/fungus/moss ingredients, etc., can solve the problem of low hardness, low tablet, tablet Fragmentation and edge knocking, etc., to achieve the effect of increasing hardness, improving brittleness and improving formability

Active Publication Date: 2018-11-30
BY HEALTH CO LTD
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the raw material containing high-oil esters accounts for more than 15%, if it is made into a tablet, the hardness of the tablet is too low, and it is easy to cause tablet fragmentation and edge knocking. For example, the main raw material formula of phytosterol ester tablets is powder Phytosterol esters (phytosterol ester content up to 50%), functional red yeast rice powder, water-soluble tomato concentrate, natural vitamin E tablets, the main raw material is vitamin E acetate powder (vitamin E content 50%), etc. will appear in tablets Technical problem with low hardness

Method used

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  • Preparation method of tablet containing grease components at high dosage

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preparation example Construction

[0020] The invention provides a specific preparation method for tablets containing high-dose oily ester components, the specific steps comprising: mixing the oily ester active material (the oil ester in the oily ester active material accounts for 30%-50% by mass of the oily ester active material) %) and the first part of silicon dioxide into a wet granulator, mix until the color is uniform, add povidone K30 aqueous solution or povidone K30 ethanol solution to granulate while stirring, and the soft material made is over 16~ 20 mesh sieve, oven-dry the sieved granules at 40℃~45℃; after drying, use 16~20 mesh sieves for granulation, add the second part of silica, adsorbent and filler after granulation , disintegrant and slip material are mixed until the color is uniform. Tablet compression was performed using a rotary tablet press.

[0021] Wherein, the oily ester active substance is a powder.

[0022] Specifically, the active oily ester is powdered phytosterol ester.

[0023]...

Embodiment 1

[0028] The phytosterol ester powder that is 30% by mass percentage (wherein, sterol ester accounts for 50% by mass percentage of phytosterol ester powder) and the silicon dioxide that is 1% by mass percentage are placed in wet granulator, add while stirring The povidone K30 aqueous solution with a mass percentage of 6% is granulated, and the soft material made is passed through a 18-mesh sieve, and the sieved granules are dried in an oven at 43°C until the granules contain 3% moisture, and then used for 18 mesh sieve for granulation; after granulation granulation, adding mass percentage is 12% functional red yeast rice powder, mass percentage is 9.5% water-soluble tomato concentrate, mass percentage is 1% silicon dioxide, mass percentage is 20% Maltodextrin, mass percent is 16% microcrystalline cellulose, mass percent is 4% crospovidone, and mass percent is 0.5% magnesium stearate, the sample of the prepared embodiment 1 is detected for its disintegration Time limit, hardness,...

Embodiment 2

[0030] The phytosterol ester powder that is 30% by mass percentage (wherein, sterol ester accounts for 50% by mass percentage of phytosterol ester powder) and the silicon dioxide that is 1% by mass percentage are placed in wet granulator, add while stirring The povidone K30 aqueous solution with a mass percentage of 6% is granulated, and the soft material made is passed through a 18-mesh sieve, and the sieved granules are dried in an oven at 43°C until the granules contain 3% moisture, and then used for 18 mesh sieve for granulation; after granulation granulation, adding mass percentage is 10% functional red yeast rice powder, mass percentage is 7.5% water-soluble tomato concentrate, mass percentage is 1% silicon dioxide, mass percentage is 18% Calcium hydrogen phosphate, the microcrystalline cellulose that mass percent is 22%, the crospovidone that mass percent is 4%, the magnesium stearate that mass percent is 0.5%, the embodiment 2 sample that will make detects its disintegr...

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Abstract

The invention belongs to the technical field of health-care products, and in particular relates to a preparation method of a tablet containing grease components at a high dosage. The preparation method of the tablet containing the grease components at a high dosage comprises the following steps: 1, mixing a grease active substance, a first part of silicon dioxide and a binding agent and implementing pelletizing, and implementing sieving and drying so as to obtain oil-containing granules, wherein in terms of mass percentage of the grease active substance, grease accounts for 30-50%; and 2, mixing the oil-containing granules, a second part of silicon dioxide, an adsorbent, a filling agent, a disintegrant, functional raw materials and a lubricating substance, and implementing tabletting, so that the tablet containing the grease components at the high dosage is prepared. According to the preparation method of the tablet containing the grease components at the high dosage, technical shortcomings of the prior art that it is difficult to conduct tabletting on grease components at a high dosage can be effectively overcome.

Description

technical field [0001] The invention belongs to the technical field of health care products, and in particular relates to a preparation method of a tablet containing high-dose oil and ester components. Background technique [0002] In tablet preparation technology, the targeted ingredients are generally non-oily solids. Because the existence of oily ingredients will lead to a series of problems in the process of tablet compression, such as: inability to form, split, low hardness of plain tablets, and inability to withstand coating operations, etc. Certainly, existing tablet technology still may be accomplished for some low-dose (<20%) oily components, but it is difficult for the tablet-making of high-dose (>20%) oily components. [0003] Health care products contain high-oil and ester raw materials, and the dosage forms are generally soft capsules, and a small amount is made into powder. Tablets generally require raw materials containing high oil and esters to accoun...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/04A61K47/32A61K36/00A23L33/115A23L33/10A23L29/00A23P10/28
CPCA61K9/2009A61K9/2027A61K9/2095A61K36/00A23L29/015A23L29/03A23L33/10A23L33/115A23P10/28
Inventor 黄仪友黄玲袁训贤贺瑞坤欧晓玲何健张旭光
Owner BY HEALTH CO LTD
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