Gynecological menstruation regulating tablet and preparation process thereof

A gynecological menstruation regulating and preparation technology, applied in the field of medicine, can solve problems such as bioavailability, unsatisfactory drug stability, low bioavailability of active ingredients, unsatisfactory curative effect, etc., to achieve improved compliance, appropriate hardness, fast onset effect

Active Publication Date: 2018-11-06
JIANGXI GUOYAO PHARMA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the reasons of prescription and process, the curative effect of Fuke Tiaojing Tablets on the market is not ideal, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect
The bioavailability and drug stability of traditional dosage forms are not ideal, especially the problem of low bioavailability of active ingredients needs to be solved urgently; in view of these situations, improving the process or composition of the prescription has become a matter that people urgently need to solve

Method used

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  • Gynecological menstruation regulating tablet and preparation process thereof
  • Gynecological menstruation regulating tablet and preparation process thereof

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preparation example Construction

[0028] The invention also provides a preparation process of Fuke Tiaomeng Tablets, in which part of the medicinal components is superfinely pulverized to obtain ultrafine powder and sterilized for use; part of the medicinal components is extracted by boiling, high-speed centrifugation, and concentrated to prepare clear ointment and thick ointment. The clear paste is used as a component of the composite binder, the thick paste is mixed with the ultrafine powder obtained by crushing, and microcrystalline cellulose, the composite binder is added to make granules, the granules are sized, mixed with other auxiliary materials, compressed into tablets, and coated to obtain the product .

[0029] In a preferred embodiment, the supplementary materials for preparing Menstruation Tablets also include 1-5 parts of Tween-80; the sterilization condition of the ultra-fine powder obtained by ultrafine pulverization is 105-110°C for 25-30min; high-speed centrifuge The rotation speed is 12000-1...

Embodiment 1

[0055] The raw material of Fuke Tiaojing Tablets is made of medicinal compound and auxiliary materials. The medicinal compound is composed of 23 parts of bran-fried Atractylodes Rhizome, 32 parts of vinegar Yanhusuo, 400 parts of vinegar cyperus, 144 parts of angelica, 11 parts of licorice, and 16 parts of Chuanxiong. 12 parts of white peony root, 48 parts of Rehmannia glutinosa, 12 parts of red peony root, 8 parts of safflower, 8 parts of motherwort, 8 parts of ginseng, 80 parts of jujube, 8 parts of lotus seeds, 8 parts of yam, 10 parts of Panax notoginseng, 5 parts of medlar The excipients are 20 parts of microcrystalline cellulose, 45 parts of composite binder, 40 parts of croscarmellose sodium starch and 15 parts of magnesium stearate.

[0056] The ratio of the clear paste, hydroxypropyl cellulose and 95% ethanol in the composite adhesive is 1g: 0.3g: 0.5mL.

[0057] The preparation process steps of Tiaojing Tablet are as follows:

[0058] (1) Grinding the aforementioned...

Embodiment 2

[0066] The raw material of Fuke Tiaojing Tablets is made of medicinal compound and auxiliary materials. The medicinal compound is composed of 20 parts of bran-fried Atractylodes Rhizome, 30 parts of vinegar Corydalis Corydalis, 380 parts of Vinegar Cyperus, 140 parts of Angelica sinensis, 10 parts of Licorice Root, and 10 parts of Rhizoma Chuanxiong. 10 parts of white peony root, 40 parts of Rehmannia glutinosa, 10 parts of red peony root, 15 parts of safflower, 10 parts of motherwort, 15 parts of ginseng, 85 parts of jujube, 15 parts of lotus seeds, 10 parts of yam, 15 parts of Panax notoginseng, 7 parts of medlar parts, auxiliary materials are 30 parts of microcrystalline cellulose, 60 parts of composite binder, 50 parts of croscarmellose sodium and 30 parts of micropowder silica gel.

[0067] The ratio of the clear paste, hydroxypropyl cellulose and 95% ethanol in the composite adhesive is 1g: 0.4g: 0.6mL.

[0068] The preparation process steps of Tiaojing Tablet are as fol...

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Abstract

The invention relates to a gynecological menstruation regulating tablet and a preparation process of the gynecological menstruation regulating tablet. The menstruation regulating tablet is prepared from rhizoma atractylodis fried with bran, vinegar rhizoma corydalis, vinegar rhizoma cyperi, angelica sinensis, liquorice, ligusticum wallichii, radix paeoniae alba, radix rehmanniae praeparata, radixpaeoniae rubra, safflower carthamus, leonurus japonicas, ginseng, Chinese date, a lotus seed, Chinese yam, pseudo-ginseng, lycium barbarum, microcrystalline cellulose, a compound adhesive, a disintegrating agent and a lubricant, wherein the compound adhesive comprises a thin paste, hydroxy propyl cellulose and ethyl alcohol, the specific gravity of the thin paste is 1.05, and the percent by volumeof the ethyl alcohol is 95%. The preparation process of the menstruation regulating tablet is as follows: superfinely grinding part of medicinal components to obtain a superfine powder, sterilizing;boiling part of medicinal components with water, extracting, centrifuging at high speed, concentrating to prepare the thin paste and a thick paste, taking the thin paste as the ingredient of the compound adhesive, mixing the thick paste with the superfine powder and the microcrystalline cellulose, adding the compound adhesive to prepare a granule, shaping the granule, mixing with other auxiliary materials, tableting, and coating to obtain a product. The prepared menstruation regulating tablet is bright, clean, fine and smooth, the thickness is even, the menstruation regulating tablet disintegrates rapidly, the dosage is low, and the curative effect is good.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a gynecological menstrual regulating tablet and a preparation process thereof. Background technique [0002] Irregular menstruation is a common gynecological disease, manifested as abnormal menstrual cycle or bleeding, or abdominal pain and systemic symptoms before or during menstruation. The cause may be organic disease or dysfunction, blood disease, hypertension, liver disease, endocrine disease, miscarriage, ectopic pregnancy, hydatidiform mole, reproductive tract infection, ovarian tumor, uterine fibroids, etc. can all cause menstrual disorders. Irregular menstruation brings great pain to women. It is easy to produce a large number of acne spots on women's faces, easily cause gynecological inflammation, and even lead to infertility, which seriously threatens women's health. In order to achieve the purpose of prevention and treatment, many inventors and pharmaceu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8945A61K9/28A61K9/30A61P15/00A61P29/00
CPCA61K9/0002A61K9/28A61K9/282A61K36/232A61K36/236A61K36/258A61K36/284A61K36/286A61K36/484A61K36/533A61K36/62A61K36/65A61K36/66A61K36/71A61K36/725A61K36/804A61K36/815A61K36/8905A61K36/8945A61K47/02A61K47/32A61K47/34A61K47/36A61K47/38A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61P15/00A61P29/00A61K2300/00
Inventor 关媛媛万义斌葛友群左飞鸿袁任春周莉萍
Owner JIANGXI GUOYAO PHARMA LLC
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